A5044061030- Parathyroid Disorders and Treatments
- Bone health and treatments
- Vitamin D Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Magnesium in Health and Disease
- Pancreatic function and diabetes
- Bone Metabolism and Diseases
- Thyroid Disorders and Treatments
- Bone health and osteoporosis research
- Genetic Syndromes and Imprinting
- Dialysis and Renal Disease Management
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Medical Imaging and Pathology Studies
- Protein Kinase Regulation and GTPase Signaling
- Thyroid and Parathyroid Surgery
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Cancer-related Molecular Pathways
Showa University Northern Yokohama Hospital
2016-2025
Showa University
2013-2025
Kumamoto Medical Center
2024
Keio University
2011-2023
Universities at Shady Grove
2021
Program for Appropriate Technology in Health
2021
GlaxoSmithKline (Belgium)
2021
Universidade Federal do Triângulo Mineiro
2019
Showa University Fujigaoka Hospital
1999-2018
The University of Tokyo
1988-2015
Fibroblast growth factor-23 (FGF-23), a novel phosphate-regulating factor, was elevated in hypophosphatemic patients with X-linked rickets/osteomalacia and also chronic kidney disease. These observations suggested the pathophysiological importance of FGF-23 on phosphate homeostasis. However, regulation production is still unclear. We investigated effects both dietary phosphorus 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) circulating vivo Administration of. 1α,25(OH)2D3 dose-dependently...
The action of insulin-like growth factor I1 (IGF-11) on calcium influx was studied in BALB/c 3T3 cells.IGF-I1 did not affect rate either quiescent or platelet-derived factor-treated "competent'' cells.In contrast, IGF-I1 induced an approximately 2-fold sustained increase competent cells briefly primed with epidermal ("primed competent" cells).The IGF-IIstimulated dependent extracellular and inhibited by lanthanum, cobalt, tetramethlin but nitrendipine.The ['Hlthymidine incorporation also...
Transforming growth factor (TGF)‐β signaling has been shown to promote tumor and metastasis in advanced cancer. Use of inhibitors TGF‐β may thus be a novel strategy for treatment patients with such cancers. In this study, we investigated the effects type I receptor (TβR‐I) kinase inhibitor, Ki26894, on bone highly bone‐metastatic variant human breast cancer MDA‐MB‐231 cells, termed MDA‐MB‐231–5a‐D (MDA‐231‐D). Ki26894 blocked MDA‐231‐D as detected by suppression phosphorylation Smad2...
Although 1, 25-dihydroxyvitamin D3 [1, 25- (OH)2D3] has been shown to inhibit the growth of certain malignant cells, its hypercalcemic effect prevented clinical application. We have recently developed a novel vitamin analog, 22-oxa-1,25-(OH)2D3 (OCT), that is capable promoting differentiation and inhibiting proliferation without inducing hypercalcemia. The present study was undertaken determine whether OCT could be applied for treatment breast cancer with or estrogen receptor (ER). inhibited...
Abstract In mouse Balb/c3T3 fibroblasts, insulin-like growth factor (IGF)-II activates a calcium-permeable cation channel through cell surface IGF-II receptor (Kojima, I., Nishimoto, Iiri, T., Ogata, E., and Rosenfeld, R. G. (1988) Biochem. Biophys. Res. Commun. 154, 9-19; Matsunaga, H., Kojima, Yamashita, N., Kurokawa, K., E. Am. J. Physiol. 255, C442-C446). the action of IGF-II, pertussis toxin (or islet-activating protein; IAP)-sensitive GTP-binding protein (G protein) is inferred to be...
To examine the role of vitamin D in renal tubular handling calcium, clearance studies were performed three groups rats: group A rats fed a standard D-deficient diet (Ca 0.45%, P 0.3%) for 6 wk, hypocalcemic with secondary hyperparathyroidism; B same as but high calcium 1.4%) and 20% lactose, normocalcemic without C supplemented 25 U D3 orally twice week, normocalcemic, D-replete, euparathyroid. After thyroparathyroidectomy (TPTX), each rat was infused intravenously an electrolyte solution...
<h3>Importance</h3> Among patients with hyperphosphatemia undergoing dialysis, it is unclear whether non–calcium-based phosphate binders are more effective than calcium-based for reducing cardiovascular events. <h3>Objective</h3> To determine lanthanum carbonate reduces events compared calcium in at risk of vascular calcification hemodialysis. <h3>Design, Setting, and Participants</h3> Open-label, randomized, parallel-group clinical trial blinded end point adjudication performed 2374 chronic...
BACKGROUND Hepatitis B (HB) virus (HBV) infection is often reactivated, leading to severe hepatitis and death. Because the actual incidence of such complications unknown, authors surveyed hospitals record these identify clinical parameters that would possibly predict development hepatic complications. METHODS First, 250 hospitals, belonging Japanese Society Clinical Hematology, were for hematologic patients with chronic or those asymptomatic in whom related chemotherapy occurred between 1987...
To clarify whether the changes of parathyroid size have any correlations with long-term prognosis calcitriol pulse therapy, we examined time course serum levels hormone (PTH) and glands in 14 chronic dialysis patients during after oral therapy. In 5 without detectable glands, secondary hyperparathyroidism was easily controlled by therapy then conventional active vitamin D 2 gland(s) whom all as well PTH hypersecretion regressed to normal could remain at least for 12 months switching...
Amyloid precursor protein (APP), a transmembrane of β-amyloid, possesses function whereby it associates with Go through its cytoplasmic His657-Lys676. Here we demonstrate that APP has receptor function. In phospholipid vesicles consisting baculovirally made APP695 and brain trimeric Go, 22C11, monoclonal antibody against the extracellular domain APP, increased GTPγS binding turnover number GTPase without affecting intrinsic activity. This effect 22C11 was specific among various antibodies...
Although alfacalcidol has been widely used for the treatment of osteoporosis in certain countries, its mechanism action bone, especially vitamin D-replete state, remains unclear. Here we provide histomorphometric as well biochemical evidence that suppresses osteoclastic bone resorption an ovariectomized rat model osteoporosis. Furthermore, when compared with 17beta-estradiol, a representative antiresorptive drug, it is evident causes dose-dependent suppression resorption, and yet maintains...
ABSTRACT. In renal failure, parathyroid hormone (PTH) is not only involved in the genesis of disturbed calcium/phosphate metabolism and ostitis fibrosa; it also a permissive factor hypertension, cardiovascular damage, dyslipidemia. The allosteric activator calcium sensing receptor NPSR-568 (R-568) has been shown to reduce serum intact PTH (iPTH) concentration uremic rats. It was purpose this study subtotally nephrectomized (SNX) rats compare pharmacologic abrogation secondary...
To examine the effects of serum calcium concentrations on PTH biosynthesis, rats were made hyper- (serum total calcium, approximately 3.5 mM) or hypocalcemic (approximately 1.25 and steady-state levels mRNA in parathyroid cells measured by primer extension method using a 32P-labeled synthetic oligomer. increased about twofold slightly infusion calcium-free solution decreased those hypercalcemic CaCl2 (120-150 mumol/h) compared with present nonfasting control rats. Infusion calcitonin (0.5...
A rise in extracellular calcium (CaZ+J suppresses not only secretion of parathyroid hormone (PTH) but also expression the PTH gene to ensure constant plasma Ca2+ level.A nuclear protein(s) a wide variety cells bound specific DNA elements (negative Ca' responsive elements, nCaREs) human sequence-specific and CaZ+, concentration-dependent manners.Our Southwestern cloning revealed that redox factor protein (refl), which was known activate several transcription factors via alterations their...
The stimulatory effect of parathyroid hormone (PTH) on renal la-hydroxylation 25- hydroxyvitamin D3 (25-OH-D3) was studied in thyroparathyroidectomized (TPTX), vitamin D-deficient rats into which bovine PTH, theophylline, cAMP or dibutyryl (dbcAMP) constantly infused. accumulation plasma 1α,25-dihydroxy [1α,25-(OH)2−D3], produced from OH-D3, enhanced by infusion either (0.9 μmol/h) dbcAMP (1 to a level similar the maximum obtained PTH (2.5-7.5 U/h) infusion. A submaximal dose caused extent...