A5006884303- Landslides and related hazards
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cryospheric studies and observations
- Sinusitis and nasal conditions
- Tracheal and airway disorders
- Voice and Speech Disorders
- Vestibular and auditory disorders
- Particle physics theoretical and experimental studies
- Gastric Cancer Management and Outcomes
- Ear Surgery and Otitis Media
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Dysphagia Assessment and Management
- Metastasis and carcinoma case studies
- Parathyroid Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Flood Risk Assessment and Management
- Asthma and respiratory diseases
- Ear and Head Tumors
- Olfactory and Sensory Function Studies
- Cancer, Hypoxia, and Metabolism
- High-Energy Particle Collisions Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
Hokkaido University Hospital
2017-2025
Kanazawa Medical University
1999-2025
NEC (Japan)
2020-2025
Nagoya University
1992-2024
Chiba Cancer Center
2024
Hokkaido University
1988-2023
National Cancer Center Hospital East
2023
Tokyo Metropolitan Hiroo Hospital
2013-2022
Kobe University
2016-2022
Akita University Hospital
1985-2022
Fibroblast growth factor-23 (FGF-23), a novel phosphate-regulating factor, was elevated in hypophosphatemic patients with X-linked rickets/osteomalacia and also chronic kidney disease. These observations suggested the pathophysiological importance of FGF-23 on phosphate homeostasis. However, regulation production is still unclear. We investigated effects both dietary phosphorus 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) circulating vivo Administration of. 1α,25(OH)2D3 dose-dependently...
The human fibroblast growth factor 23 (hFGF23) and its autosomal dominant hypophosphatemic rickets (ADHR) mutant genes were incorporated into animals by naked DNA injection to investigate the action on phosphate homeostasis <i>in vivo</i>. hFGF23 mutants (R176Q, R179Q, R179W) markedly reduced serum phosphorus (6.2–6.9 mg/dl) compared with plasmid MOCK (8.5 mg/dl). However, native did not affect (8.6 Both hFGF23R179Q mRNAs expressed more than 100-fold in liver 4 days after injection, however,...
Epidermolysis bullosa acquisita (EBA) is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies specific to type VII collagen, major constituent of the dermal-epidermal junction. Previous attempts transfer disease by injection patient into mice have been unsuccessful. To study pathogenic relevance antibodies collagen in vivo, we generated characterized rabbit murine form this antigen passively transferred them adult nude, BALB/c, C57BL/6 mice. Immune...
Epidermolysis bullosa acquisita (EBA) is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies specific to type VII collagen, major constituent of the dermal-epidermal junction. Previous attempts transfer disease by injection patient into mice have been unsuccessful. To study pathogenic relevance antibodies collagen in vivo, we generated characterized rabbit murine form this antigen passively transferred them adult nude, BALB/c, C57BL/6 mice. Immune...
MicroRNAs (miRNAs) belong to a class of the endogenously expressed non-coding small RNAs which primarily function as gene regulators. Growing evidence suggests that miRNAs have significant role in tumor development and may constitute robust biomarkers for cancer diagnosis prognosis. The miR-17-92 cluster especially is markedly overexpressed several cancers, associated with progression. In this study, we demonstrated miR-92a highly hepatocellular carcinoma (HCC). addition, proliferation...
The migration and positioning of osteoclast precursor monocytes are controlled by the blood-enriched lipid mediator sphingosine-1-phosphate (S1P) have recently been shown to be critical points control in osteoclastogenesis bone homeostasis. Here, we show that calcitriol, which is hormonally active form vitamin D, its therapeutically used analog, eldecalcitol, inhibit resorption modulating this mechanism. Vitamin D analogs clinically for treating osteoporosis, although mode pharmacologic...
Recently, epidemiologic and experimental studies have been reported that long-term macrolides are effective for the treatment of chronic airway inflammatory diseases including diffuse panbronchiolitis, rhinosinusitis, cystic fibrosis (Jaffe A, Francis J, Rosenthal M, et al. Long-term azithromycin may improve lung function in children with fibrosis. Lancet 351:420, 1998), can directly reduce production IL-8 by nasal epithelial cells (Suzuki H, Shimomura Ikeda K, Inhibitory effect on...
FGF23 (fibroblast growth factor 23) is a novel phosphaturic that influences vitamin D metabolism and renal re-absorption of Pi. The goal the present study was to characterize role VDR (vitamin receptor) in action using VDR(−/−) (VDR null) mice. Injection FGF23M (naked DNA encoding R179Q mutant human FGF23) into wildtype VDR(+/+) mice resulted an elevation serum levels, but had no effect on calcium or parathyroid hormone levels. In contrast, injection significant decreases Pi Na/Pi...
Abstract Eldecalcitol (ED-71) is a new vitamin D3 derivative recently approved for the treatment of osteoporosis in Japan. Previous studies have shown that daily administration ED-71 increases bone mineral density (BMD) by suppressing resorption various animal models. In this study, we examined how suppresses vivo, analyzing histomorphometry and ex vivo osteoclastogenesis assays. Daily (50 ng/kg body weight) to 8-week-old male mice 2 4 weeks increased BMD femoral metaphysis without causing...
Mass movements caused by rainfall events in Taiwan are analyzed during a 7-year period from 2006 to 2012. Data the Soil and Water Conservation Bureau reports were compiled for 263 mass movement events, including 156 landslides, 91 debris flows, 16 with both landslides flows. Rainfall totals each site location obtained interpolated rain gauge data. The intensity–duration (I–D) relationship was examined establish threshold using random sampling: I = 18.10(±2.67)D −0.17(±0.04), where is mean...
Research Article| November 01, 2014 Rainfall conditions, typhoon frequency, and contemporary landslide erosion in Japan H. Saito; Saito 1College of Economics, Kanto Gakuin University, 1-50-1 Mutsuura-higashi, Yokohama, Kanagawa 236-8501, Japan2Center for Spatial Information Science, The University Tokyo, 5-1-5 Kashiwanoha Kashiwa, Chiba 277-8568, Search other works by this author on: GSW Google Scholar O. Korup; Korup 3Institute Earth Environmental Sciences, Potsdam, Karl-Liebknecht-Strasse...
Unmanned aerial systems (UASs) and structure-from-motion multi-view stereo (SfM-MVS) photogrammetry have attracted a tremendous amount of interest for use in the creation high-definition topographic data geoscientific studies. By using these techniques, this study examined characteristics coseismic landslides triggered by 2016 Kumamoto earthquake (Mw 7.1) Sensuikyo area (1.0 km2) at Aso volcano, Japan. The has frequently experienced rainfall-induced landslide events, such as those 1990,...
Abstract Storm‐induced landslides are a common hazard, but the link between their spatial pattern and rainfall properties is poorly understood, mostly because hillslope stability modulated by under‐constrained, spatially variable topographic, hydrological, mechanical properties. Here, we use long‐term data set from Japanese radar network to discuss why landslide caused major typhoon correlates with event agrees normalized 10‐year return period amount, that is, anomaly. This may be explained...
The present study compares the long-term follow-up results of electrogustometry with patient reports taste dysfunction after middle ear surgery.Retrospective review 371 patients who underwent surgery.Patients were divided into following groups depending on degree manipulation or surgical damage to chorda tympani nerves: no-touch group (group 1 [n = 109]); touch 2 149]); and severed nerve 3 113]). Electrogustometry was periodically performed over course several years.The incidences...
A cellulase (endo‐β‐1,4‐glucanase, EC 3.2.1.4) was purified from the gut of larvae yellow‐spotted longicorn beetle Psacothea hilaris by acetone precipitation and elution gels after native PAGE SDS/PAGE with activity staining. The protein formed a single band, molecular mass estimated to be 47 kDa. degraded carboxymethylcellulose (CMC), insoluble cello‐oligosaccharide (average degree polymerization 34) soluble cello‐oligosaccharides longer than cellotriose, but not crystalline cellulose or...