A5033529548- Olfactory and Sensory Function Studies
- Parathyroid Disorders and Treatments
- Retinal Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Vitamin D Research Studies
- Birth, Development, and Health
- Biochemical Analysis and Sensing Techniques
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone health and osteoporosis research
- Developmental Biology and Gene Regulation
- Hormonal Regulation and Hypertension
- Bone health and treatments
- Adrenal Hormones and Disorders
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Maternal and fetal healthcare
- Pancreatic function and diabetes
- Amphibian and Reptile Biology
- Genetic Syndromes and Imprinting
- Neonatal and fetal brain pathology
- Dialysis and Renal Disease Management
- Magnesium in Health and Disease
- Electrolyte and hormonal disorders
- Reproductive System and Pregnancy
Shonan Oiso Hospital
2018-2025
Ebina General Hospital
2025
Kagawa University
2019-2024
Japan Wildlife Research Center
2010-2024
Nara Medical University
2010-2021
Kaken Pharmaceutical (Japan)
2021
Jichi Medical University
2018-2020
John Wiley & Sons (United States)
2019
Hudson Institute
2019
Tokai University
2011-2016
In the visual system, establishment of anteroposterior and dorsoventral axes in retina tectum during development is important for topographic retinotectal projection. We identified chick Ventroptin, an antagonist bone morphogenetic protein 4 (BMP-4), which mainly expressed ventral retina, not only with a high–dorsal low gradient but also nasal high–temporal at later stages. Misexpression Ventroptin altered expression patterns several genes projection retinal axons to along both axes. Thus,...
To examine the role of vitamin D in renal tubular handling calcium, clearance studies were performed three groups rats: group A rats fed a standard D-deficient diet (Ca 0.45%, P 0.3%) for 6 wk, hypocalcemic with secondary hyperparathyroidism; B same as but high calcium 1.4%) and 20% lactose, normocalcemic without C supplemented 25 U D3 orally twice week, normocalcemic, D-replete, euparathyroid. After thyroparathyroidectomy (TPTX), each rat was infused intravenously an electrolyte solution...
The stimulatory effect of parathyroid hormone (PTH) on renal la-hydroxylation 25- hydroxyvitamin D3 (25-OH-D3) was studied in thyroparathyroidectomized (TPTX), vitamin D-deficient rats into which bovine PTH, theophylline, cAMP or dibutyryl (dbcAMP) constantly infused. accumulation plasma 1α,25-dihydroxy [1α,25-(OH)2−D3], produced from OH-D3, enhanced by infusion either (0.9 μmol/h) dbcAMP (1 to a level similar the maximum obtained PTH (2.5-7.5 U/h) infusion. A submaximal dose caused extent...
Sensory experience regulates the development of various brain structures, including cortex, hippocampus, and olfactory bulb (OB). Little is known about how sensory dendritic spine OB interneurons, such as granule cells (GCs), although it well studied in mitral/tufted cells. Here, we identify a transcription factor, Npas4, which expressed GCs immediately after input required for formation. Npas4 overexpression increases density, even under deprivation, rescues reduction dendrite density...
Klotho is a transmembrane protein that functions as coreceptor for fibroblast growth factor 23 (FGF23). cleaved and released into the circulation; however, main site of production, physiological role, regulation soluble in humans are largely unknown. The aim this study was to determine impact parathyroidectomy (PTx) on serum FGF23 levels patients with severe secondary hyperparathyroidism. This prospective, single-arm trial conducted at Tokai University School Medicine. Thirteen hemodialysis...
Neural circuits that undergo reorganization by newborn interneurons in the olfactory bulb (OB) are necessary for odor detection and discrimination, memory, innate responses, including predator avoidance sexual behaviors. The OB possesses many interneurons, various types of granule cells (GCs); however, contribution each type interneuron makes to behavioral control remains unknown. Here, we investigated <i>in vivo</i> functional role oncofetal trophoblast glycoprotein 5T4, a regulator...
Recent experimental studies have reported that fibroblast growth factor 23 (FGF23) inhibits erythropoiesis by suppressing erythropoietin (EPO) production and downregulating the EPO receptor. Conversely, either endogenous or exogenous has been shown to stimulate FGF23 production. However, little is known about relationships between FGF23, erythropoiesis-stimulating agent (ESA) treatment, ESA resistance, in hemodialysis patients. We analyzed cross-sectional data from a cohort of 654...
Abstract To clarify how the changes in bone formation and resorption affect volume strength after mechanical unloading, effect of inhibition by a potent bisphosphonate, pamidronate, on mineral density (BMD), histology, hind limb bones was examined using tail-suspended growing rats. Tail suspension for 14 days reduced gain BMD femur at both metaphysis rich trabecular diaphysis cortical bone. Treatment with pamidronate increased total as well that but had almost no control Histological...
The effect of natural salmon calcitonin on accumulation in plasma 1 alpha,25-dihydroxy-[3H]cholecalciferol from 25-hydroxy[3H]cholecalciferol vivo was investigated vitamin D-deficient thyroparathyroidectomized rats into which graded doses the hormone were continuously infused by use a balance study system. A dose-dependent increase concentrations alpha,25-dihydroxy[3H]cholecalciferol observed with infusion for 6–30h at rate greater than 20 M.R.C. m-units/h. Infusion parathyrin or cyclic AMP...
Sensory input has been shown to regulate development in a variety of species and various structures, including the retina, cortex, olfactory bulb (OB). Within mammalian OB specifically, dendrites mitral/tufted cells is well known be odor-evoked activity dependent. However, little about developmental role sensory other major population GABAgenic interneurons, such as granule periglomerular cells. Here, we identified, with DNA microarray situ hybridization screenings, trophoblast glycoprotein...
We previously reported that MOLT-3 human lymphocyte-like leukemia cells adhere to tissue-type transglutaminase (tTG) through the integrin α<sub>4</sub>β<sub>1</sub>. now report G-361 melanoma also tTG, although they do not express utilize two additional integrins, α<sub>9</sub>β<sub>1</sub> and α<sub>5</sub>β<sub>1</sub> tTG. Furthermore, blood coagulation factor XIII (FXIII), another member of family is highly homologous propolypeptide von Willebrand (pp-vWF) promoted cell adhesion or...
Chick brain factor 1 (CBF1), a nasal retina-specific winged-helix transcription factor, is known to prescribe the specificity that leads formation of precise retinotectal map, especially along anteroposterior (AP) axis. However, its downstream topographic genes and molecular mechanisms by which CBF1 controls expression them have not been elucidated. We show misexpression represses EphA3 CBF2, induces SOHo1,GH6, ephrin A2 A5. A5by DNA binding-dependent mechanism, binding-independent SOHo1,...
It has been long believed that the anteroposterior (A-P) and dorsoventral (D-V) axes in developing retina are determined independently also retinotectal projection along two is controlled independently. However, we recently demonstrated misexpression of Ventroptin, a bone morphogenic protein (BMP) antagonist, chick alters not only D-V (or mediolateral) axis but A-P axis. Moreover, dorsal-high expression BMP4 relieved by dorsotemporal-high BMP2 at embryonic day 5 (E5) retina, during which...
Background Normal tissue damage caused by radiotherapy remains the largest dose‐limiting factor in for cancer. Therefore, aim of this study was to investigate supplementary oral 5‐aminolevulinic acid (ALA) standard radiation therapy as a novel radioprotective approach that would not compromise antitumor effect normal rectal and bladder mucosa syngenic prostate cancer (PCa) model. Methods To evaluate radiosensitizing ALA vitro, clonogenic survival assays were performed DU145, PC3, MyC‐CaP...
FreeStyle Libre has been approved for use in patients undergoing hemodialysis (HD) Japan, unlike Europe and the United States; however, evidence regarding its accuracy such is sparse. Forty-one participants with type 2 diabetes HD were recruited. The overall mean absolute relative difference 23.4% 33.9 mg/dL, respectively. Sensor glucose levels capillary significantly correlated (r = 0.858, P < .01), although sensor lower than levels. of became deteriorated days usage. percentage results...
Acute kidney injury (AKI), accompanied by the development of systemic inflammatory response syndrome and multiorgan dysfunction syndrome, is associated with a high risk death. Bioartificial renal tubule device (BTD) cell therapy that improves conditions common to artificial recipients treated for diseases. In this paper, we describe establishment BTD lifespan-extended human proximal tubular epithelial cells. AKI goats were established performing bilateral nephrectomy followed...
Significance Stroke is the second leading cause of death and most frequent disability in adults. After stroke, ischemic neurons die a few live, to brain dysfunction; yet, genes involved both neuronal survival remain poorly understood. Here, we found that activity-dependent transcription factor Npas4 essential for acquisition tolerance ischemia. Moreover, systematic search Npas4-downstream identified Gem , which encodes Ras-related small GTPase mediates neuroprotective effects Npas4....