A5036582307- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Advanced Glycation End Products research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Diabetes Management and Education
- Cerebrovascular and Carotid Artery Diseases
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Diabetic Foot Ulcer Assessment and Management
- Pharmacology and Obesity Treatment
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Vitamin C and Antioxidants Research
- RNA modifications and cancer
- Renal function and acid-base balance
- Genetics and Neurodevelopmental Disorders
- Studies on Chitinases and Chitosanases
Tokushima University
2016-2025
Hiroshima University
2020
Takara (Japan)
2019
Tokushima University Hospital
2012
Osaka University
1991-2011
City of Hope
2008-2009
City Of Hope National Medical Center
2009
Beckman Research Institute
2008
Kwansei Gakuin University
2000-2003
Sumitomo Dainippon Pharma (Japan)
2003
Background Insulin is a critical component of metabolic control, and as such, insulin gene expression has been the focus extensive study. DNA sequences that regulate transcription majority regulatory factors have already identified. However, only recently other components investigated, in this study we examine role methylation regulation mouse human expression. Methodology/Principal Findings Genomic samples from several tissues were bisulfite-treated sequenced which revealed...
Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well with aging patients diabetes. The loss muscle mass and strength, so-called sarcopenia dynapenia, has recently been recognized complication. However, the influence accumulated AGEs on strength remains unclear. present study aimed to evaluate association dynapenia type 2 diabetes.We recruited 166 diabetes aged ≥30...
To evaluate whether low-grade inflammation contributes to early-stage advanced carotid atherosclerosis in young subjects with type 1 diabetes.The mean and maximum (max) intima-media thicknesses (IMT) of the artery were assessed using ultrasound B-mode imaging 55 patients diabetes (22 men 33 women, aged 22.1 +/- 3.6 years (+/- SD), duration 14.2 5.7 years) 75 age-matched healthy nondiabetic (28 47 women). High-sensitive C-reactive protein (hs-CRP) levels measured a latex-enhanced...
Abstract Accumulation of advanced glycation end‐products ( AGE s) is thought to contribute muscle weakness in a diabetic animal model. Skin autofluorescence proposed marker for accumulation s the skin. We aimed investigate relationship between accumulation, sarcopenia and function Japanese patients with type 1 diabetes. A total 36 diabetes participated present cross‐sectional study. Sarcopenia parameters (skeletal mass index knee extension strength) were compared subcutaneous using skin...
Abstract Aims/Introduction The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia dynapenia, which are muscle weakness with without low mass, respectively, in Japanese patients type 1 diabetes mellitus 2 mellitus. Materials Methods This cross‐sectional enrolled 1,328 participants ( n = 177), 645) 506). Sarcopenia was defined as a grip strength slow gait speed skeletal mass index, whereas dynapenia strengths knee extension normal index. Participants were...
Recent studies have implicated epigenetics in the pathophysiology of diabetes. Furthermore, DNA methylation, which irreversibly deactivates gene transcription, insulin promoter, particularly cAMP response element, is increased diabetes patients. However, underlying mechanism remains unclear. We aimed to investigate promoter methylation an over-nutrition state. INS-1 cells, rat pancreatic beta cell line, were cultured under normal-culture-glucose (11.2 mmol/l) or experimental-high-glucose...
ABSTRACT Aims/Introduction This study examined the effects of high‐intensity interval walking training (IWT) compared to moderate‐intensity continuous (CWT) on muscle strength, ability, and health‐related quality life (QOL) in people with diabetes accompanied by lower extremity weakness. Materials Methods People low isometric knee extensor strength using a simple manual dynamometer ( n = 50) were screened randomly divided into 2 groups: CWT 25) IWT 25). Both groups instructed physical...
Background: The relationship between the percent coefficient of variation (%CV) and risk severe hypoglycemia (SH) or non-severe (NSH) in patients with type 1 diabetes (T1D) remains to be elucidated. Materials Methods: Effect Intermittent-Scanning Continuous Glucose Monitoring Glycemic Control Including Hypoglycemia Quality Life Patients Type Diabetes Mellitus (ISCHIA) study was a crossover, randomized, controlled trial for prevention T1D using multiple daily injections (MDIs). Blinded...
DNA methylation is a mechanism by which cells control gene expression, and cell-specific genes often exhibit unique patterns of methylation. We previously reported that the mouse insulin-2 (Ins2) promoter has three potential (CpG) sites, all are unmethylated in insulin-producing but methylated other tissues. In this study we examined Ins2 exon 2 found similar tissue-specific pattern. These can differentiate between from beta hypothesized damaged release their into circulation at onset type 1...
To investigate the basal insulin requirement in total daily dose Japanese type 1 diabetic patients who use pump.The 35 without detectable C-peptide using pump (Paradigm 712) was investigated during 2-3 weeks of hospitalization. The were served diets 25-30 kcal/kg ideal body weight. Each meal omission done to confirm stable blood glucose levels within 30 mg/dL variance until next meal. Target level set at 100 before each and 150 2 h after meal.Total 31.6 ± 8.5 units, 8.7 2.9 which 27.7 6.9%...
Aim: Accumulation level of fluorescent advanced glycation end products (AGEs) in the skin can be measured non-invasively as autofluorescence (skin AF) by reader. The aim this study was to assess possible associations between AF and diabetic complications, especially early-stage atherosclerosis, Japanese type 1 patients.
We examined the relationship between presence and extent of coronary stenosis carotid intima-media thickness (CIMT) in type 2 diabetic patients without history artery disease (CAD) but with atherosclerosis.A total 91 underwent multi-slice computed tomography angiography.Max-IMT ≥ 50% group by angiography estimation was significantly greater than 0-25 25-50% (2.68 ± 0.77 vs. 1.61 0.49 mm, P < 0.0005, 2.14 0.81 0.05, respectively), max-IMT 0-25% (P 0.05) after adjustment for age, sex, duration...
FreeStyle Libre has been approved for use in patients undergoing hemodialysis (HD) Japan, unlike Europe and the United States; however, evidence regarding its accuracy such is sparse. Forty-one participants with type 2 diabetes HD were recruited. The overall mean absolute relative difference 23.4% 33.9 mg/dL, respectively. Sensor glucose levels capillary significantly correlated (r = 0.858, P < .01), although sensor lower than levels. of became deteriorated days usage. percentage results...
YKL-40 is a marker of inflammation and endothelial dysfunction, both which play important roles in the progression diabetic complications. However, little information has been obtained about serum levels type 1 patients. We evaluated its association with micro- macroandgiopathy 131 young Japanese patients without advanced complications (aged 24.7±5.9 years) 97 age- gender-matched healthy controls. were significantly elevated than controls (median (range) 46.4 (20.3-136.7) 52.3 (21.4-274.1)...
Computed tomography (CT) and ultrasound were used to evaluate intrahepatic biliary calculi in 16 patients. Thirteen demonstrated high-density shadows dilated ducts on CT. Of the 11 who also underwent ultrasonography, 7 had positive findings. Strong echoes with acoustic are diagnostic of stones. CT useful evaluating calculi, being particularly helpful postoperative cases.
Background: Insulin is a critical component of metabolic control, and as such, insulin gene expression has been the focus extensive study.DNA sequences that regulate transcription majority regulatory factors have already identified.However, only recently other components investigated, in this study we examine role DNA methylation regulation mouse human expression.Methodology/Principal Findings: Genomic samples from several tissues were bisulfite-treated sequenced which revealed...