A5051701813- Diabetes Treatment and Management
- Diabetes Management and Research
- Pancreatic function and diabetes
- Advanced Chemical Sensor Technologies
- Biosensors and Analytical Detection
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Potassium and Related Disorders
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Genetics and Neurodevelopmental Disorders
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Protein Kinase Regulation and GTPase Signaling
- Hemoglobinopathies and Related Disorders
- Diabetes and associated disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
Hamamatsu University Hospital
2025
Hamamatsu University School of Medicine
2011-2024
High-sensitivity C-reactive protein (hs-CRP) is a marker for low-grade inflammation, as well atherosclerosis, obesity, hyperglycemia and hypertension. Because the factor showing strongest association with inflammation currently unknown, we investigated associations between hs-CRP clinical biochemical characteristics in Japanese subjects mild obesity or impaired glucose tolerance.Subjects aged <65 years old, attending Seirei Medical Examination Center, underwent complete physical laboratory...
Accumulating evidence has demonstrated that both SGLT2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1Ra) have protective effects in patients with diabetic kidney disease. Combination therapy SGLT2i GLP1Ra is commonly used type 2 diabetes (T2D). We previously reported combination of GLP1Ra, the effect on renal composite outcome did not differ according to preceding drug. However, it remains unclear how initiation associated function depending In this post hoc analysis, we analyzed a...
FreeStyle Libre has been approved for use in patients undergoing hemodialysis (HD) Japan, unlike Europe and the United States; however, evidence regarding its accuracy such is sparse. Forty-one participants with type 2 diabetes HD were recruited. The overall mean absolute relative difference 23.4% 33.9 mg/dL, respectively. Sensor glucose levels capillary significantly correlated (r = 0.858, P < .01), although sensor lower than levels. of became deteriorated days usage. percentage results...
Abstract Aim To conduct a post hoc subgroup analysis of patients with type 2 diabetes (T2D) from the RECAP study, who were treated sodium‐glucose cotransporter‐2 (SGLT2) inhibitor and glucagon‐like peptide 1 receptor agonist (GLP‐1RA) combination therapy, focusing only on those had chronic kidney disease (CKD), to examine whether composite renal outcome differed between received SGLT2 treatment first GLP‐1RA first. Methods We included 438 CKD (GLP‐1RA‐first group, n = 223; inhibitor‐first...
Aims Combination therapy with sodium-glucose cotransporter inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP1Ras) is now of interest in clinical practice. The present study evaluated the effects preceding drug type on renal outcome Methods We retrospectively extracted 2 diabetes mellitus patients who had received both SGLT2i GLP1Ra treatment for at least 1 year. A total 331 GLP1Ra-preceding group 312 SGLT2i-preceding were ultimately analyzed. Either progression albuminuria status and/or...
Objective The mechanism by which G-protein-coupled receptor 40 (GPR40) signaling amplifies glucose-stimulated insulin secretion through activation of protein kinase C (PKC) is unknown. We examined whether a GPR40 agonist, GW9508, could stimulate conventional and novel isoforms PKC at two glucose concentrations (3 mM 20 mM) in INS-1D cells. Methods Using epifluorescence microscopy, we monitored relative changes the cytosolic fluorescence intensity Fura2 as marker change intracellular Ca2+...
BACKGROUND:Sodium-glucose cotransporter-2 (SGLT2) inhibitors are new antihyperglycemic drugs for type 2 diabetes. SGLT2 ameliorate cardiovascular morbidity and mortality as well kidney disease progression by reducing body weight (BW), blood pressure (BP), visceral adiposity, albuminuria, serum uric acid glucose levels. However, it is not clear which effects pronounced, what mechanisms associated with these effects. MATERIAL AND METHODS:This study recruited patients diabetes who were...
Abstract Purpose Type 2 diabetes mellitus (T2DM) emphasizes the maintenance of high levels physical activity and requires interventions tailored to characteristics each patient. We hypothesized that T2DM combined with diabetic kidney disease (DKD) could increase skeletal muscle fatigability, becoming a specific contributor inactivity. This study aimed determine effects DKD complications on fatigability relationship between in patients T2DM. Methods The participants were 50 aged 40–65 years...
<title>Abstract</title> Purpose We evaluated the effects of sodium-glucose cotransporter inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP1Ras) combination treatment in patients with type 2 diabetes mellitus (T2DM). Methods retrospectively analyzed data for 643 T2DM receiving SGLT2i + GLP1Ra at least one year (331 312 GLP1Ra- SGLT2i-preceding groups, respectively). used multiple imputation to generate replacement values missing data, thereafter, performed sensitivity analysis on complete...
<sec> <title>BACKGROUND</title> Background: Visual judgment is susceptible to human errors, such as evaluation item errors and time variations. Automated Urine Test Strip Colorimetric testing may be used by practitioners small-scale medical check-up facilities test urine samples. </sec> <title>OBJECTIVE</title> Objective: We develop an automated strip colorimetric program using images taken with a smartphone camera judge the color of urinalysis strips objectively. <title>METHODS</title>...
One method for noninvasive and simple urinary microalbumin testing is urine test strips. However, when visually assessing strips, accurate assessment may be difficult due to environmental influences-such as lighting color intensity-and the physical psychological influences of assessor. These complicate formation an objective assessment. This study developed "automated strip colorimetric program" (hereinafter referred "this program") objectively assess Using this program allow tests conducted...
The transcription factor GATA2 regulates gene expression in several cells and tissues, including hematopoietic tissues the central nervous system. Recent studies revealed that loss-of-function mutations are associated with hematological disorders. Our earlier vitro showed plays an essential role hypothalamus–pituitary–thyroid axis (HPT axis) by regulating genes encoding prepro-thyrotropin-releasing hormone (preproTRH) thyroid-stimulating β (TSHβ). However, effect of mutants on...
Objective: The Angiotensin-II receptor blocker telmisartan and sulfonylurea glimepiride may have clinical usefulness as partial agonists of PPARg.We investigated additive antagonistic effects among combinations telmisartan, glimepiride, the Thiazolidinedione (TZD) selective PPARg agonist pioglitazone on transcriptional activity PPARg.Materials/Methods: receptors pCMX-PPARg pCMX-RXR, PPRE-Luc reporter gene were transfected into CV1 cells, treated with following agents, luciferace assay was...