A5089533893- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Kruppel-like factors research
- Parathyroid Disorders and Treatments
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Connective Tissue Growth Factor Research
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacology and Obesity Treatment
- Protein Kinase Regulation and GTPase Signaling
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Bone health and treatments
- Hormonal Regulation and Hypertension
- Apelin-related biomedical research
- Angiogenesis and VEGF in Cancer
- Sphingolipid Metabolism and Signaling
- Diet and metabolism studies
- Blood Coagulation and Thrombosis Mechanisms
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Biomarkers in Disease Mechanisms
Fukuoka University
2019-2025
Arkana Laboratories
2023
RELX Group (United States)
2022
Jikei University School of Medicine
2010-2019
Japan Institute for Advanced Dentistry
2019
University Hospitals Cleveland Medical Center
2008-2012
Case Western Reserve University
2008-2012
Pulmonary Vascular Research Institute
2012
University School
2008-2010
Cornell University
2010
Krüppel-like factor (KLF)2 is a central regulator of endothelial and monocyte/macrophage gene expression function in vitro. Although the composite effects KLF2 these 2 cell types predict that it likely inhibits vascular inflammation, role this process vivo uncharacterized. In study, we provide evidence hemizygous deficiency increased diet-induced atherosclerosis apolipoprotein E-deficient mice. Our studies highlight an important for primary macrophage foam formation via potential regulation...
The ability of skeletal muscle to enhance lipid utilization during exercise is a form metabolic plasticity essential for survival. Conversely, inflexibility in can cause organ dysfunction and disease. Although the transcription factor Kruppel-like 15 (KLF15) an important regulator glucose amino acid metabolism, its endogenous role homeostasis physiology unknown. Here we demonstrate that KLF15 physiologic performance. directly regulates broad transcriptional program spanning all major...
Endothelial PAS domain protein 1 (EPAS1) is a basic-helix-loop-helix/PAS transcription factor that expressed preferentially in vascular endothelial cells. EPAS1 shares high homology with hypoxia-inducible factor-1alpha (HIF-1alpha) and reported to transactivate growth (VEGF), fetal liver kinase-1 (Flk-1), Tie2 promoters. In this study, we analyzed the role of process angiogenesis. Using microarray technology, looked for target genes regulated by A total 130 were upregulated EPAS1, including...
A central function of the endothelium is to serve as a selective barrier that regulates fluid and solute exchange. Although perturbation can contribute numerous disease states, our understanding molecular mechanisms regulating this aspect endothelial biology remains incompletely understood. Accumulating evidence implicates Kruppel-like factor 2 (KLF2) key regulator function. However, its role in vascular unknown.To assess KLF2 vivo, we measured leakage Evans blue dye into interstitial...
The co-occurrence of heart failure and aortic aneurysms may be explained by their common dependence on a transcriptional regulator, which now presents possible therapeutic target.
Hypoxia-inducible factor 1 (HIF-1) is a central regulator of the hypoxic response in many cell types. In endothelial cells, HIF-1 induces expression key proangiogenic factors to promote angiogenesis. Recent studies have identified Kruppel-like 2 (KLF2) as potent inhibitor However, role KLF2 regulating and function has not been evaluated. was induced acutely by hypoxia cells. Adenoviral overexpression inhibited hypoxia-induced HIF-1alpha its target genes such interleukin 8, angiopoietin-2,...
Diabetic nephropathy (DN) not only is a major cause of end-stage renal disease (ESRD) in developing and developed countries but also plays critical role as risk factor for cardiovascular disease. The pathogenesis DN multifactorial remains to be elucidated. It well known that dyslipidemia frequently complicated with diabetes. Recently, has been recognized involved the progression DN. In general, diabetic caused by impaired action lipoprotein lipase (LPL) localized endothelial cells, resulting...
Cancer is currently one of the major causes death in patients with type 2 diabetes mellitus. We previously reported beneficial effects glucagon-like peptide-1 receptor agonist exendin-4 against prostate and breast cancer. In present study, we examined anti-cancer effect sodium-glucose cotransporter (SGLT2) inhibitor ipragliflozin using a cancer model. human MCF-7 cells, SGLT2 expression was detected both RT-PCR immunohistochemistry. Ipragliflozin at 1–50 μM significantly dose-dependently...
PIONEER REAL Japan was a non-interventional prospective study of oral semaglutide in adults with type 2 diabetes Japanese clinical practice.
The small GTPase Rho and its effector kinase (ROCK) are involved in the pathogenesis of diabetic kidney disease. has two isoforms: ROCK1 ROCK2. However, it remains unclear which is mainly progression glomerulosclerosis regulation profibrotic mediators. Glomeruli isolated from type 2 db/db mice demonstrated increased gene expression transforming growth factor (TGF)-β downstream Chemical inhibition ROCK suppressed mediators both glomeruli cultured mesangial cells. An investigation mechanisms...
The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various cellular functions, including organization of the actin cytoskeleton, cell adhesion migration. A pro-inflammatory lipid mediator, lysophosphatidic acid (LPA), is a potent activator Rho/ROCK signalling pathway has been shown to induce expression chemokines molecules (CAMs). In present study, we aimed elucidate precise mechanism by which ROCK regulates LPA-induced expressions functions CAMs. We observed that...
Abstract In this study, we aimed to separately evaluate the relationship between waist circumference and incidence of hyperuricemia in men women general Japanese population. We performed a population-based longitudinal study using data from annual health examination residents Iki City, Japan. A total 5567 participants without at baseline were included analysis. The placed into groups according tertile circumference. outcome was incident (uric acid > 416 µmol/L [7.0 mg/dL]). investigated...