A5101815254- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Systemic Lupus Erythematosus Research
- Muscle and Compartmental Disorders
- Vasculitis and related conditions
- Diabetes Management and Research
- Enhanced Recovery After Surgery
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Diet and metabolism studies
- Renin-Angiotensin System Studies
- Natural Antidiabetic Agents Studies
- Cardiovascular Health and Disease Prevention
- Cholesterol and Lipid Metabolism
- History of Science and Medicine
Fukuoka University
2015-2025
Okayama University
2022
Fukuoka University Hospital
2022
California Institute for Regenerative Medicine
2021
University of Pennsylvania
2021
Gunma University
2021
Kanazawa Medical University
2021
Tottori University
2021
Monash University
2019
Monash Medical Centre
2019
Abstract In this study, we aimed to separately evaluate the relationship between waist circumference and incidence of hyperuricemia in men women general Japanese population. We performed a population-based longitudinal study using data from annual health examination residents Iki City, Japan. A total 5567 participants without at baseline were included analysis. The placed into groups according tertile circumference. outcome was incident (uric acid > 416 µmol/L [7.0 mg/dL]). investigated...
It has been suggested that non-fasting triglyceride (TG) concentrations may be useful in predicting various diseases. However, current epidemiological evidence focuses mainly on the effects of fasting TG concentrations. The aim this study was to investigate effect and levels new-onset hyperuricemia (HUA) general Japanese population. This is a population-based retrospective cohort (ISSA-CKD study); it included 5,576 participants without HUA at baseline between 2008 2019. Participants were...
BACKGROUND: If it were possible to deduce the mechanism of injury in cryopreserved embryos by their appearance, would help optimize cryopreservation protocols. METHODS: Mouse blastocysts treated so that they damaged six types cryoinjuries listed below, and appearance was observed at recovery sucrose solution a modified phosphate-buffered saline (PB1), after culture for 1 24 h. RESULTS: (i) Intracellular ice: shrank normally solution, but swelled PB1 collapsed culture. (ii) Chemical toxicity...
Although the accumulation of advanced glycation end products (AGEs) Maillard reaction in our body is reported to increase with aging and enhanced by pathogenesis lifestyle related diseases such as diabetes, routine measurement AGEs not applied regular clinical diagnoses due lack con ventional reliable techniques for analyses.In pres ent study, a non invasive measuring device was developed association between skin diabetic complications evaluated.To clarify duration hyperglycemia...
Objectives This study aimed to clarify the relationship between white blood cell (WBC) count and hypertension in general Japanese population. Methods We conducted a population-based retrospective cohort using annual health check-up data of residents Iki City, Nagasaki Prefecture, Japan. A total 2935 participants without at baseline were included present analysis. WBC counts classified as tertile 1 (<4700/μL), 2 (4700–5999/μL), 3 (≥6000/μL). The outcome was incident (blood pressure ≥140...
<b><i>Background:</i></b> Kidney disease is characterized by injurious immune responses to self or foreign antigens. The development and maintenance of generally involves activation T lymphocytes. We evaluated mRNA expression patterns T-cell cytokines identify the principal Th-cell subset involved in antineutrophil cytoplasmic antigen-associated pauci-immune crescentic glomerulonephritis (ANCAGN), membranoproliferative (MPGN), membranous nephropathy (MN)....
Both body mass index (BMI) and waist circumference (WC) are associated with diabetes risk, the difference between them in predictive ability for is still contentious. We conducted a population-based study to investigate compare association of by sex. This included total 4754 subjects aged 40–80 years no at baseline 2008 2017. Using multivariate Cox proportional hazards models, we calculated hazard ratios according tertiles BMI or WC. Harrell's C statistics was applied assess models using WC...
Background The gut bacterial microbiota is altered in patients with chronic kidney disease (CKD). However, the composition at each stage of CKD unclear these patients, including those receiving renal replacement therapy. We herein report changes among CKD.
Abstract Objectives The purpose of this study was to evaluate the effects tissue‐engineered bone ( TEB ) on osteotome technique with simultaneous implant placement that is applied severe resorption in maxilla for earlier regeneration and minimal invasive operation. Material methods We injectable , which composed marrow‐derived mesenchymal stem cells BMMSC s) as cell source platelet‐rich plasma an autologous scaffold signal molecules, 23 cases. After dental implants were pre‐prepared pilot...
Although incretin therapy is clinically available in patients with type 2 diabetes undergoing hemodialysis, no study has yet examined whether capable of maintaining glycemic control this group when switched from insulin therapy. In study, we the efficacy insulin-treated hemodialysis.Ten diabetic hemodialysis received daily 0.3 mg liraglutide, 50 vildagliptin, and 6.25 alogliptin on both day non-hemodialysis day. Blood glucose level was monitored by continuous monitoring. After blood insulin,...
Background: We investigated whether eating speed was associated with the incidence of diabetes in a Japanese general population. Methods: A total 4853 individuals without at baseline were analyzed. Self-reported categorized as slow, medium, and fast on basis questionnaire responses. The study outcome diabetes. Results: After an average follow-up period 5.1 years, 234 developed per 1000 person-years 4.9 slow group, 8.8 medium 12.5 respectively (*** p < 0.001 for trend). HRs 1.69 (95%CI...
The application of cell-biomaterial systems in tissue engineering and regenerative medicine is an important challenge biomedicine, which preserves not only cells, but also tissue-engineered constructs. In this study, the constructs cryoprotectant parameters were optimized, it was evaluated whether characteristics dental pulp stem cells (DPSCs), have high proliferation ability as maintained during encapsulation cryopreservation. optimal gel with gelation rate 2% alginate: 100 mM CaCO(3): 200...
Objective The revised Standards of Medical Care in Diabetes-2018 recommend a less-intensive HbA1c target for elderly individuals than younger ones. This study aimed to investigate the development and progression chronic kidney disease (CKD) according levels separately middle-aged general Japanese population. Methods was retrospective cohort using health checkup data Iki City, Japan. participants were 5,554 residents who attended checkups more 2 times over 8 years. consists two sets analyses...
Background Because of their capacity to induce antigen-specific immunosuppression, tolerogenic dendritic cells are a promising tool for treatment autoimmune conditions, such as GN caused by autoimmunity against myeloperoxidase (MPO).We sought generate suppress anti-MPO culturing bone marrow with an NFκB inhibitor (BAY 11-7082) and exposing them pulse MPO. After administering these MPO/BAY or saline mice established anti-methylated BSA (mBSA) immunity, we assessed immune responses GN. We also...
Background: There is uncertainty surrounding the causal relationship between serum uric acid and hypertension. The aim was to investigate association prevalence of hypertension in a general population Japanese. Methods: This population-based cross-sectional study using health check-up data residents Iki City, Nagasaki Prefecture, Japan. A total 7,484 participants aged 30 years or older were included this study. Serum classified into four groups: group 1 (< 357 µmol/L 6 mg/dL)), 2 (357 - 415...
Advanced glycation end products (AGEs), produced by the Maillard reaction between carbohydrates and proteins, may be involved in diabetes its complications. Accurate quantification of AGEs vivo can demonstrate relation pathological conditions, but it is not widely used clinical practice because multiple pretreatment steps before analyses. We developed a fully automated solid-phase extraction system (FSPES) to simplify rate-limiting using cation exchange column. applied this device evaluate...
Objective We aimed to clarify the relationship between serum alanine transaminase (ALT) levels and incidence of new-onset diabetes in a Japanese general population. Setting Population-based retrospective cohort study using annual health check-up data for residents Iki City, Nagasaki Prefecture, Japan. Participants A total 5330 individuals (≥30 years old) without at baseline were analysed. Primary secondary outcome measures Serum ALT determined an enzymatic method classified into...
To obtain a clear understanding of the pathogenesis lipoprotein glomerulopathy (LPG), we studied role deficiency Fc receptor gamma chain (FcRγ) for development LPG in concert with apolipoprotein E (apoE) abnormalities. We generated apoE and FcRγ double-knockout (FcRγ/apoE-KO) mice, subsequently introduced several kinds human recombinant genes. At 21 days after infection, mice were sacrificed histologically examined. Peritoneal macrophages evaluated their response to modified lipids. In...
Lupus nephritis is one of the most serious complications systemic lupus erythematosus and manifests with considerable phenotypic histological heterogeneity. In particular, diffuse proliferative (DPLN) membranous (MLN) represent morphologic forms that are polar opposites. DPLN associated autoimmune responses dominated by Th1 immune response high levels interferon (IFN)-γ. contrast, a Th2 cytokine pathogenesis MLN. MRL/lpr mice develop human LN-like complex-associated provide suitable model...