A5055953176- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Elasticity and Material Modeling
- Lymphoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Aortic aneurysm repair treatments
- Atherosclerosis and Cardiovascular Diseases
- Viral-associated cancers and disorders
- Coronary Interventions and Diagnostics
- Acute Ischemic Stroke Management
- Connective tissue disorders research
- Antioxidant Activity and Oxidative Stress
- Cell Adhesion Molecules Research
- Alcohol Consumption and Health Effects
- Asthma and respiratory diseases
- Lipoproteins and Cardiovascular Health
- Intracranial Aneurysms: Treatment and Complications
- Natural Antidiabetic Agents Studies
- Aortic Disease and Treatment Approaches
- Histiocytic Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Neurological Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Allergic Rhinitis and Sensitization
Kobe City Medical Center General Hospital
2023
Social Insurance Saitama Chuo Hospital
2022
Saitama Medical University
2022
Fukuoka University
2010-2020
Kyushu Institute of Technology
2007-2020
Komatsu (Japan)
2013
Pediatrics and Genetics
2011
Kyushu University
1997-2007
Kagoshima University
2007
Toneyama National Hospital
2005
Inflammatory abdominal aortic aneurysm (IAA) is associated with autoimmune disease. However, the precise mechanism of IAA remains unclear. There increasing evidence that IgG4 involved in various idiopathic sclerosing lesions, including pancreatitis and retroperitoneal fibrosis. The present study investigated hypothesis IgG4-related reaction formation IAA. group consisted 11 cases (69.2 +/- 8.59y) 12 age-matched atherosclerotic (AAA, 69.6 5.94y), which were used previous report. A...
We studied the role of inducible nitric oxide synthase (iNOS) in septic lung injury using a novel and selective iNOS inhibitor (a fused piperidine derivative; ONO-1714) following cecal ligation puncture (CLP) procedure. All rats that received CLP died within 48 h after intervention. The subcutaneous injection ONO-1714 at 0.03 mg/kg every 12 resulted significantly longer survival time than saline control only when administration was started other schedules, which immediately or 6...
Although the accumulation of advanced glycation end products (AGEs) Maillard reaction in our body is reported to increase with aging and enhanced by pathogenesis lifestyle related diseases such as diabetes, routine measurement AGEs not applied regular clinical diagnoses due lack con ventional reliable techniques for analyses.In pres ent study, a non invasive measuring device was developed association between skin diabetic complications evaluated.To clarify duration hyperglycemia...
We attempted to elucidate the contribution of complement allergic asthma. Rat sensitized OVA received repeated intratracheal exposures for up 3 consecutive days, and pulmonary resistance was then estimated 6 h after last exposure. Whereas immediate airway response (IAR) in terms R(L) tended decrease proportion number exposures, late (LAR) became prominent only three. Although premedication with two kinds inhibitors, soluble receptor type 1 (sCR1) or nafamostat mesylate, resulted inhibition...
Background Few studies have evaluated the distinct ability of contrast-enhanced ultrasonography for detecting carotid plaque rupture versus histological observations. Aims The aim this study was to quantitatively assess detect compared ultrasonographic and images in terms geometric accordance. Methods Carotid morphology classified as “smooth,” “irregular,” or “ulcerated” on 45 conventional from consecutive patients undergoing endarterectomy, 55 regions interests were captured...
Objective: The purpose of this study was to clarify the role glycoxidation and lipid peroxidation low-density lipoprotein (LDL) in atherogenesis. Methods results: We examined formation Nϵ-(carboxymethyl) lysine (CML), a product, malondialdehyde (MDA), vitro their co-localization human atherosclerotic lesions. Immunochemical analysis revealed that CML formed time-dependent manner by LDL incubated with copper ions glucose, i.e. an model LDL. When exposed alone, small amount formed, however...
Recent immunohistological studies using antibodies against advanced glycation end products (AGEs) have demonstrated the presence of AGEs in several tissues. By an enzyme-linked immunosorbent assay monoclonal anti-AGE antibody, present study aimed to determine pepsin-insoluble collagen (PIC) as well pepsin-soluble (PSC) from aortas streptozotocin (STZ)-induced diabetic rats (at 4, 16, and 28 weeks after STZ injection) those agematched control rats. Addition EDTA immunoassay buffer has led us...
AbstractInvolvement of oxidative stress is implicated in the progression complication diabetes mellitus. With respect to heart diseases, we have studied role stress/antioxidants using rats treated with streptozotocin induce (DM). Hemodynamic and echocardiographic measurements showed thickening wall an increase internal dimension left ventricle (LV) DM at 8th week. Decrease diastolic posterior velocity rate LV pressure change, end pressures also proved cardiac dysfunction. These changes were...
Apart from ACE, various angiotensin II (Ang II)-forming serine proteinases (eg, chymase, kallikrein, and cathepsin G) are known to exist in human tissues, but their clinical significance or the regulatory mechanisms that control activities not well established. A recent study has shown chymase activity was significantly increased atherosclerotic aneurysmal aorta. The association between vascular Ang II-forming (AIIFAs) internal thoracic artery (ITA) parameters studied with use of ITAs...
Since the accumulation of Nε-(carboxymethyl)lysine (CML), a major antigenic advanced glycation end product, is implicated in tissue disorders hyperglycemia and inflammation, identification pathway CML formation will provide important information regarding development potential therapeutic strategies for these complications. The present study was designed to measure effect hypochlorous acid (HOCl) on from Amadori products. incubation glycated human serum albumin (glycated-HSA), model...