A5085034288- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Estrogen and related hormone effects
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Biomarkers in Disease Mechanisms
- Cerebrovascular and genetic disorders
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Oral and Maxillofacial Pathology
- Lung Cancer Research Studies
Gunma University
2015-2024
International University of Health and Welfare
2023
Anglia Ruskin University
2023
Gunma University Hospital
2001-2020
Gunma Prefectural Institute of Public Health and Environmental Sciences
2020
Osaka University
2015
Fukushima Medical University
2015
Dokkyo Medical University
2006-2012
National Hospital Organization
2011
Dokkyo University
2005-2008
// Hideyuki Takahashi 1 , Koichi Sakakura Takeshi Kudo Minoru Toyoda Kyoichi Kaira 2 Tetsunari Oyama 3 Kazuaki Chikamatsu Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School Medicine, Gunma, Japan Oncology Clinical Development, Pathology, Correspondence to: Chikamatsu, email: tikamatu@gunma-u.ac.jp Keywords: cancer-associated fibroblast (CAF), tumor-associated macrophage (TAM), tumor microenvironment (TME), immunomodulation, immunosuppression Received: August...
Beta-adrenergic blockade has been associated with improved cancer survival in patients triple-negative breast (TNBC), but the mechanisms of these effects remain unclear. In clinical epidemiological analyses, we identified a relationship between beta-blocker use and anthracycline chemotherapy protecting against TNBC progression, disease recurrence, mortality. We recapitulated effect beta-blockade on efficacy xenograft mouse models TNBC. metastatic 4T1.2 MDA-MB-231 TNBC, doxorubicin by...
ErbB2-negative breast tumors represent a significant therapeutic hurdle because of lack effective molecular targets. Although NOTCH proteins are known to be involved in mammary tumorigenesis, the functional significance these is not clear. In present study, we examined expression activated receptors human cancer cell lines, including and ErbB2-positive lines. Activated NOTCH1 NOTCH3 generated by gamma-secretase were detected most lines tested, both CSL-mediated transcription. Down-regulation...
Triple negative breast cancer (TNBC) is a heterogeneous, aggressive for which there no effective chemotherapy or targeted therapy. We aimed to evaluate L-type amino acid transporter (LAT) 1 and CD98 expression immunohistochemically in patients with cancer, especially TNBC. Out of 129 patients, LAT1 was positive 56 (43.4%), 41 (31.8%). The ratio luminal A cases 7.9%, 30.0% B cases, 71.4% HER2 64.0% TN cases. subtypes expressed at higher levels than (both P < 0.001). correlated tumor size...
Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA). Our objective was to investigate expression and mutations Japanese APA. We sequenced cDNA measured mRNA levels 23 APA operated on at Gunma University Hospital. were examined compared those cortisol-producing (Cushing's syndrome) pheochromocytomas. Of APA, 15 (65.2%) had two somatic gene: 12 cases p.G151R (eight c.451G>A, four c.451G>C) three p.L168R (c.503T>G). Levels...
The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific and has been shown to have essential roles in cell growth survival. However, little known regarding the clinical significance LAT1 pancreatic cancer. This study was conducted determine prognostic expression. A total 97 consecutive patients with surgically resected pathological stage I–IV ductal adenocarcinoma were retrospectively reviewed. Tumour sections stained by immunohistochemistry for LAT1, CD98, Ki-67 vascular...
Amino-acid transporters are necessary for the tumour cell growth and survival, have a crucial role in development invasiveness of cancer cells. But, it remains unclear about prognostic significance L-type amino-acid transporter 1 (LAT1), system ASC transporter-2 (ASCT2), xCT expression patients with tongue cancer. We conducted clinicopathological study to investigate protein these Eighty-five surgically resected were evaluated. Tumour sections stained by immunohistochemistry LAT1, ASCT2,...
ASC amino-acid transporter 2 (ASCT2) is a major glutamine that has an essential role in tumour growth and progression. Although ASCT2 highly expressed various cancer cells, the clinicopathological significance of its expression non-small cell lung (NSCLC) remains unclear. One hundred four patients with surgically resected NSCLC were evaluated as one institutional cohort. Tumour sections stained by immunohistochemistry (IHC) for ASCT2, Ki-67, phospho-mTOR (mammalian target rapamycin), CD34 to...
The response of human epidermal growth factor receptor2 (HER2)- positive breast cancer (BC) patients to anti-HER2 targeted therapy is significant. However, the not uniform and a proportion HER2-positive do respond. This study aims identify predictors in neoadjuvant treatment assess discordance rate HER2 status between pre- post-treatment specimens BC patients. group comprised 500 treated with chemotherapy (NACT) and/or surgery who had tumours that were 3+ or 2+ immunohistochemistry (IHC)....
Rationale:The tumor microenvironment (TME) and its multifaceted interactions with cancer cells are major targets for treatment.Single-cell technologies have brought insights into the TME, but resulting complexity often precludes conclusions on function.Methods: We combined single-cell RNA sequencing spatial transcriptomic data to explore relationship between different cancer-associated fibroblast (CAF) populations immune cell exclusion in breast tumors.The significance of findings was then...
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A total of 110 cases thyroid carcinomas were examined immunohistochemically to evaluate the overexpression mutant forms p53 protein in light their relationship with histological subtypes. polyclonal antibody, CM-1, was applied routine formalin-fixed, paraffin-embedded tissues for this survey. Overall, detected expression confined nucleus identified 22.7% carcinomas. significant difference positivity among subtypes noted; 11.1% well-differentiated papillary carcinoma, 14.3% follicular 40.9%...
The expression of L-type amino acid transporter 1 (LAT1) has been described to play essential roles in tumor cell growth and survival. However, it remains unclear about the clinicopathological significance LAT1 biliary tract cancer. This study was conducted determine biological investigate whether could be a prognostic biomarker for A total 139 consecutive patients with resected pathologic stage I-IV adenocarcinoma were retrospectively reviewed. Tumor specimens stained by...
In squamous cell carcinoma (SCC) of the tongue and floor mouth (FOM), it is important to predict lymph node metastasis, including occult before operating. The purpose this study was for us determine practical histopathologic parameters as predictive factors metastasis in preoperative SCC biopsy specimens.We examined 91 cases conventional assessment a new factor, tumor budding, their relationship with metastasis.Significant via univariate analysis (p < .01) were budding (score ≥3) depth (≥3...
Tumor-associated macrophages (TAM) have been classified into an immunostimulatory M1 subset against microbes and malignancies, immunoregulatory M2 that secretes immunosuppressive cytokines in order to repair tissues damaged by malignancies. The infiltration of the tumor microenvironment is known facilitate immunosuppression tumor-promoting properties. In present study, we investigated phagocytic potential these macrophage subsets oral squamous cell carcinoma (OSCC) relation expression CD47,...
Tumour‑infiltrating lymphocytes (TILs) are regarded as significant prognostic markers in patients with breast cancer. However, the utility of TIL expression based on intrinsic subtypes has just been identified. The present study investigated relationship between grades and prognosis 294 Japanese paitents cancer stratified clinicopathological characteristics. Stromal status was evaluated using haematoxylin eosin staining, were categorised into low (<10%), intermediate (≥10 ≤40%) high (>40%)...
The CDKN2 gene encodes two structurally different proteins: a cyclin-dependent kinase inhibitor, p16, which regulates retinoblastoma protein (pRb)-dependent G1 arrest, and cell cycle p14ARF, blocks MDM2-induced p53 degradation resulting in an increase levels that leads to arrest. Recent studies have revealed expression of p16 p14ARF is influenced markedly by the status pRb p53, overexpression has been demonstrated cervical neoplasia because functional inactivation human papillomavirus (HPV)...
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal in digestive tract and majority of GIST has characteristic gain‐of‐function mutations c‐kit gene, which encodes KIT receptor for stem cell factor. The present study aimed to establish usefulness protein kinase C theta (PKC θ) as an immunohistochemical marker comparison with immunohistochemistry. PKC θ immunohistochemistry was carried out not only on 48 cases another 40 gastrointestinal tumors, but also 24 various tumors...