A5002514266- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Cardiac Imaging and Diagnostics
- Schizophrenia research and treatment
- Advanced Breast Cancer Therapies
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Alkaloids: synthesis and pharmacology
- Cancer Cells and Metastasis
- Cancer and Skin Lesions
- Restless Legs Syndrome Research
- Metastasis and carcinoma case studies
- Parkinson's Disease Mechanisms and Treatments
- Neonatal Health and Biochemistry
- Epilepsy research and treatment
- Sleep and related disorders
- Bone health and treatments
- Electroconvulsive Therapy Studies
- Neuroscience and Neuropharmacology Research
International University of Health and Welfare
2017-2024
Shimane University
2013-2023
Gunma University
2009-2023
Anglia Ruskin University
2023
National Hospital Organization
2012-2019
Tokyo Medical University
1993-2019
Dokkyo Medical University
2019
Niigata University
2019
Yodogawa Christian Hospital
2019
Gunma University Hospital
2007-2018
Purpose: To show that prospective electrocardiographically (ECG)-triggered coronary computed tomographic (CT) angiography (hereafter, CT angiography) is at least as effective retrospective ECG-gated angiography). Materials and Methods: Institutional review committee approval informed consent were obtained. Sixty patients with heart rates of less than 75 beats per minute who referred for enrolled. Both performed a 64-detector scanner. Data acquisition times recorded. Two independent cardiac...
Summary The aim of this study is evaluating iron, ferritin, and transferrin in both serum CSF patients restless legs syndrome (RLS), based on the hypothesis that iron deficiency central nervous system (CNS) causes symptoms as a result dysfunction dopaminergic systems. These parameters, polysomnographic sleep measures, subjective evaluation quality were compared 10 idiopathic RLS (RLS group) age‐matched psychophysiological insomnia without (non‐RLS group). With patterns, latency was longer...
The purpose of our study was to evaluate the diagnostic performance sonographic elastography and B-mode sonography individually combined in differentiation reactively metastatically enlarged cervical lymph nodes.Eighty-five nodes (metastatic, n = 53; reactive, 32) from 37 patients were examined by both this prospective study. Elastographic patterns determined on distribution percentage node area with high elasticity (hard), pattern 1 being an absent or very small hard 5, a occupying entire...
Triple negative breast cancer (TNBC) is a heterogeneous, aggressive for which there no effective chemotherapy or targeted therapy. We aimed to evaluate L-type amino acid transporter (LAT) 1 and CD98 expression immunohistochemically in patients with cancer, especially TNBC. Out of 129 patients, LAT1 was positive 56 (43.4%), 41 (31.8%). The ratio luminal A cases 7.9%, 30.0% B cases, 71.4% HER2 64.0% TN cases. subtypes expressed at higher levels than (both P < 0.001). correlated tumor size...
Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA). Our objective was to investigate expression and mutations Japanese APA. We sequenced cDNA measured mRNA levels 23 APA operated on at Gunma University Hospital. were examined compared those cortisol-producing (Cushing's syndrome) pheochromocytomas. Of APA, 15 (65.2%) had two somatic gene: 12 cases p.G151R (eight c.451G>A, four c.451G>C) three p.L168R (c.503T>G). Levels...
Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase, and has been shown to delay disease in mouse model of neuropsychiatric disorders. Recently, we reported the antipsychotic effects minocycline patients with schizophrenia. In pilot investigation, administered (150 mg/d) for 4 weeks as an open-label adjunct medication 22 The Positive Negative Syndrome Scale schizophrenia showed statistically significant robust clinical improvements treatment, which were maintained...
Rationale:The tumor microenvironment (TME) and its multifaceted interactions with cancer cells are major targets for treatment.Single-cell technologies have brought insights into the TME, but resulting complexity often precludes conclusions on function.Methods: We combined single-cell RNA sequencing spatial transcriptomic data to explore relationship between different cancer-associated fibroblast (CAF) populations immune cell exclusion in breast tumors.The significance of findings was then...
Aberrantly expressed microRNA (miRNA) are known to disrupt intracellular RNA networks in cancer cells. Exploring miRNA‐dependent molecular is a major challenge research. In this study, we performed RNA‐sequencing of breast (BrCa) clinical specimens identify tumor‐suppressive miRNA BrCa. total, 64 were identified as candidate BrCa Analysis our signature revealed that several duplexes (guide strand/passenger strand) derived from pre‐miRNA downregulated tissues (e.g. miR‐99a‐5p/‐3p ,...
Tumour‑infiltrating lymphocytes (TILs) are regarded as significant prognostic markers in patients with breast cancer. However, the utility of TIL expression based on intrinsic subtypes has just been identified. The present study investigated relationship between grades and prognosis 294 Japanese paitents cancer stratified clinicopathological characteristics. Stromal status was evaluated using haematoxylin eosin staining, were categorised into low (<10%), intermediate (≥10 ≤40%) high (>40%)...
L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed regulate tumor metabolism and be associated with proliferation. In invasive breast cancer, we clinicopathologically investigated the utility of LAT1 expression. expression was evaluated via immunohistochemistry analyses in 250 cancer patients undergoing long-term follow-up. We assessed relationships between patient outcomes clinicopathological factors. Breast cancer-specific survival stratified by assessed. Human...
Abstract Resveratrol (Res) is a phytoestrogen found in grapes and present red wine. Res has been shown to function as an estrogen receptor (ER) agonist, but it remains unclear whether may also exert antagonist activity. Our aim was study the effects of at both molecular (TGFα gene activation) cellular (cell growth) levels breast cancer cells stably transfected with wild‐type (wt) ER(D351) mutant (mut) ER (D351Y). TGFα mRNA induction used specific marker estradiol (E 2 ) responsiveness....
The purpose of the present paper was to evaluate prevalence restless legs syndrome (RLS) in a non-institutionalized Japanese elderly population. subjects consisted 8900 people >65 years age belonging Seniors Association Izumo City November 2000. study conducted two parts. phase 1 investigation screening by mailed questionnaire and 2 diagnosis face-to-face interview. Subjects with possible cases RLS proceeded definite were then detected. In 1, total 3287 completely answering all items,...