A5021895360- Model Reduction and Neural Networks
- Vestibular and auditory disorders
- Tracheal and airway disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Fluid Dynamics and Vibration Analysis
- Dysphagia Assessment and Management
- Cancer Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Fluid Dynamics and Turbulent Flows
- Pleural and Pulmonary Diseases
- Gallbladder and Bile Duct Disorders
- Microplastics and Plastic Pollution
- Cerebral Venous Sinus Thrombosis
- Pregnancy and preeclampsia studies
- biodegradable polymer synthesis and properties
- Glaucoma and retinal disorders
- Ear Surgery and Otitis Media
- Aortic aneurysm repair treatments
- Schizophrenia research and treatment
- Voice and Speech Disorders
- Medical Research and Treatments
- Esophageal and GI Pathology
- Congenital heart defects research
- Histone Deacetylase Inhibitors Research
- Amoebic Infections and Treatments
Shonan Kamakura General Hospital
2018-2024
Keio University
1997-2021
Murata (United States)
2021
Murata (Japan)
2020
Gunma University
2004-2017
Suita Tokushukai Hospital
2014
SUNY College of Environmental Science and Forestry
2009
State University of New York
2009
Tokyo University of Science
2005-2009
National Institute for Basic Biology
2005-2009
Using a large-scale nationwide survey database, we investigated the epidemiological characteristics for idiopathic SSNHL in Japan.The subjects this analysis were patients registered Japanese multicentre database between April 2014 and March 2016. A total of 3419 clinical obtained. Several factors associated with severity hearing impairment prognosis then investigated. Statistical was performed to clarify prognosis.There significant correlations loss diabetes mellitus, kidney disease, past...
Tumor-associated macrophages (TAM) have been classified into an immunostimulatory M1 subset against microbes and malignancies, immunoregulatory M2 that secretes immunosuppressive cytokines in order to repair tissues damaged by malignancies. The infiltration of the tumor microenvironment is known facilitate immunosuppression tumor-promoting properties. In present study, we investigated phagocytic potential these macrophage subsets oral squamous cell carcinoma (OSCC) relation expression CD47,...
Recent progression in the understanding of stem cell biology has greatly facilitated identification and characterization cancer cells ( CSC s). Moreover, evidence accumulated indicating that conventional treatments are potentially ineffective against CSCs . Histone deacetylase inhibitors HDAC i) have multiple biologic effects consequent to alterations patterns acetylation histones a promising new group anticancer agents. In this study, we investigated two i, suberoylanilide hydroxamic acid...
The development of axons and dendrites is controlled by small GTP-binding proteins the Rho family, but upstream signaling mechanisms responsible for such regulation remain unclear. We have now investigated role transmembrane protein cluster differentiation 47 (CD47) in this process with hippocampal neurons. CD47-deficient neurons manifested markedly impaired axons, whereas overexpression CD47 promoted development. Interaction SH2 domain-containing tyrosine phosphatase substrate-1 (SHPS-1)...
Objectives: The aim of this study was to investigate the differences between idiopathic sudden sensorineural hearing loss (SSNHL), and acute low-tone (ALHL) using results a nationwide survey database in Japan analyze variables associated with their clinical features severity impairment, treatment, prognosis.Methods: Participants were patients registered April 2014 March 2016 multicenter epidemiological involving 30 university hospitals medical centers across Japan. Statistical analysis...
The vancomycin-resistant enterococci GV1, GV2 and GV3, which were isolated from droppings broiler farms in Japan have been characterized as VanA-type VRE, express high-level vancomycin resistance (256 or 512 μg ml−1, MIC) low-level teicoplanin (1 2 MIC). resistances encoded on plasmids. conjugative plasmid pMG2 was the strain. VanA determinant of showed same genetic organization that genes representative transposon Tn1546, comprises vanRSHAXYZ. nucleotide sequences all genes, except gene...
A variant in a transcription factor gene, POU4F3, is responsible for autosomal dominant nonsyndromic hereditary hearing loss, DFNA15. To date, 14 variants, including whole deletion of have been reported to cause HL various ethnic groups. In the present study, genetic screening POU4F3 variants was carried out large series Japanese loss (HL) patients clarify prevalence and clinical characteristics DFNA15 population. Massively parallel DNA sequencing 68 target candidate genes utilized 2,549...
Severe stress induces changes in neuronal function that are implicated stress-related disorders such as depression. The molecular mechanisms underlying the response of brain to remain primarily unknown, however. Signal regulatory protein α (SIRPα) is an Ig-superfamily undergoes tyrosine phosphorylation and binds phosphatase Shp2. Here we show mice expressing a form SIRPα lacks most cytoplasmic region manifest prolonged immobility (depression-like behavior) forced swim (FS) test. FS induced...
Short-chain-length/medium-chain-length (SCL/MCL) polyhydroxyalkanoate (PHA) was produced in the plastids of Arabidopsis thaliana. Phe87Thr (F87T) mutated 3-ketoacyl-acyl carrier protein (ACP) synthase III (FabH) from Escherichia coli, and Ser325Thr/Gln481Lys (ST/QK) (PhaC1) Pseudomonas sp. 61−3, along with β-ketothiolase (PhaA) acetoacetyl-CoA reductase (PhaB) Ralstonia eutropha (Cupriavidus necator) genes were introduced into Arabidopsis. The transgenic PHA copolymers composed monomers...
The majority of hearing loss due to mumps presents as unilateral profound sensorineural loss, which is refractory treatment. In rare cases bilateral total deafness, cochlear implants were beneficial for speech perception. Vaccination against recommended prevent mumps-associated loss.The objective this study investigate the clinical characteristics and evaluate outcomes.The parameters analyzed under a retrospective multi-institutional design in patients diagnosed with at Otolaryngology...
Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural loss (SSNHL) treated with different initial therapies.Methods: Subjects consisted patients diagnosed SSNHL within 7 days from onset and showing severe (≥60 dB), who were registered in a Japanese multicenter database between April 2014 March 2016. divided into four groups according to therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic (ITS), (4) no steroids. Hearing outcomes compared...
Objectives: A nationwide epidemiological survey involving 23 hospitals in Japan was conducted and the predictive values of demographic data were examined statistically.Methods: total 642 patients from hospitals, including 20 university enrolled study. Age ranged 8 to 87 years, all diagnosed with acute low-tone sensorineural hearing loss (ALHL) between 1994 2016. Demographic for patients, such as symptoms, gender, mean age, distribution ALHL grading, collected analyzed relation prognosis...
We perform a sparse identification of nonlinear dynamics (SINDy) for low-dimensionalized complex flow phenomena. first apply the SINDy with two regression methods, thresholded least square algorithm (TLSA) and adaptive Lasso (Alasso) which show reasonable ability wide range sparsity constant in our preliminary tests, to two-dimensional single cylinder wake at $Re_D=100$, its transient process, two-parallel cylinders, as examples high-dimensional fluid data. To handle these high dimensional...
CD47 and SHPS-1 are transmembrane proteins that interact with each other through their extracellular regions constitute a bidirectional cell-cell communication system (the CD47–SHPS-1 system). We have now shown the trans-interaction of occurred on contact CD47-expressing CHO cells SHPS-1-expressing resulted in endocytosis ligand-receptor complex into either cell type. Such trans-endocytosis by was found to be mediated clathrin dynamin. A juxtamembrane region indispensable for efficient CD47,...
Objectives: ACTG1 has been reported to be a causative gene for autosomal dominant sensorineural hearing loss, DFNA20/26. In this study we sought clarify the detailed mutational spectrum, clinical features, and genotype-phenotype correlations. Methods: Massively parallel DNA sequencing (MPS) of 63 target candidate genes was used screen 1120 Japanese loss patients. Results: MPS screening successfully identified 4 mutations in 5 families. The majority patients showed high frequency–involved...
Incubations of rat anterior pituitary cells with transforming growth factor (TGF)-beta 1 for 48 hr suppressed the secretion basal prolactin (PRL) in a dose-dependent manner (ED50, 100 pg/ml). Activin, gonadal hormone processing cysteine distribution similar to TGF beta, also PRL secretion, but it was less effective 4 mg/ml). Treatment beta significantly from after 24 and up 72 incubation. inhibited thyrotropin-releasing hormone-mediated activin slightly, significantly. In addition, we...
Abstract Objectives/Hypothesis: Arytenoid adduction (AA) is the most effective procedure for improving voice function in patients affected by unilateral vocal fold paralysis (UVFP), but it often associated with severe complications following airway obstruction. The aim of this study to describe a new and less invasive AA surgical termed endoscopic‐assisted surgery (EAAS) evaluate its outcomes. Study Design: We demonstrated method using extirpated larynges from three laryngeal cancer...
Abstract Human ACTG1 mutations are associated with high-frequency hearing loss, and patients in this gene good candidates for electric acoustic stimulation. To better understand the genetic etiology of loss cases, massively parallel DNA sequencing was performed on 7,048 unrelated Japanese probands. Among 1,336 autosomal dominant patients, we identified 15 probands (1.1%) 13 potentially pathogenic variants. Six variants were novel seven previously reported. We collected analyzed detailed...
In this study, the enhancement of photosynthetic PHA production was achieved using highly active mutants synthase created by in vitro evolutionally techniques. The wild-type and mutated genes from Aeromonas caviae were introduced into Arabidopsis thaliana together with NADPH-dependent acetoacetyl-CoA reductase gene Ralstonia eutropha. Expression genes, N149S D171G, led to an 8−10-fold increase content T1 transgenic Arabidopsis, compared plants harboring gene. homozygous T2 progenies, further...