A5020969588- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Head and Neck Anomalies
- Head and Neck Cancer Studies
- Hernia repair and management
- Bone and Joint Diseases
- Cellular transport and secretion
- Genetic Neurodegenerative Diseases
- Tracheal and airway disorders
- Body Composition Measurement Techniques
- Hereditary Neurological Disorders
- Ear and Head Tumors
- Frailty in Older Adults
- Nutrition and Health in Aging
- Glaucoma and retinal disorders
- Brain Metastases and Treatment
- Ophthalmology and Eye Disorders
- Spinal Hematomas and Complications
- Case Reports on Hematomas
- Genetics and Neurodevelopmental Disorders
- Congenital Ear and Nasal Anomalies
- Hearing Loss and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Inflammatory Biomarkers in Disease Prognosis
Shinshu University
2016-2023
Ōtani University
2016
Ikeda Municipal Hospital
2013
The present study revealed that various etiologies are involved in single-sided deafness (SSD), and the cause of SSD asymmetrical hearing loss (AHL) differed greatly between congenital/early-onset cases adult cases. Clarification etiology is first step toward providing appropriate intervention.The aimed to clarify AHL patients.The a total 527 or patients who visited Shinshu University Hospital 2006 2016 were analyzed by imaging as well serological tests for mumps virus, CMV DNA testing.In...
A variant in a transcription factor gene, POU4F3, is responsible for autosomal dominant nonsyndromic hereditary hearing loss, DFNA15. To date, 14 variants, including whole deletion of have been reported to cause HL various ethnic groups. In the present study, genetic screening POU4F3 variants was carried out large series Japanese loss (HL) patients clarify prevalence and clinical characteristics DFNA15 population. Massively parallel DNA sequencing 68 target candidate genes utilized 2,549...
The OTOA gene (Locus: DFNB22) is reported to be one of the causative genes for non-syndromic autosomal recessive hearing loss. copy number variations (CNVs) identified in this are also known cause loss, but have not been Japanese patients with Furthermore, clinical features OTOA-associated loss yet clarified. In study, we performed CNV analyses a large cohort, and CNVs 234 2262 (10.3%, 234/2262) Among CNVs, gene-related were second most frequent (0.6%, 14/2262). 14 cases, 2 individuals...
Abdominal wall hematomas are an uncommon cause of acute abdominal pain and often misdiagnosed. They more common in elderly individuals, particularly those under anticoagulant therapy. Most occur the rectus sheath, within oblique muscle very rare poorly described literature. Here we report case hematoma a middle-aged patient who was not A 42-year-old Japanese man presented with painful, enlarging, lateral mass, which appeared after playing baseball. computed tomography ultrasonography showed...
Abstract This study aimed to investigate the prognostic value of hematological biomarkers measured before and after treatment in patients with head neck cancer (HNC). reviewed 124 HNC who received chemoradiotherapy. Hematological assessed were investigated. The pretreatment C-reactive protein/albumin ratio (pre-CAR) post-treatment nutritional index (post-PNI) showed highest area under curve cutoff values 0.0945 34.9, respectively. Patients high pre-CAR group significantly worse prognosis...
The purpose of this study was to assess the diagnostic performance 3T MRI after intratympanic injection gadodiamide for delayed endolymphatic hydrops (DEH), and relationship between (ELH) vestibular function in patients diagnosed with DEH confirmed by MRI. Nineteen clinically (11 ipsilateral DEH, 8 contralateral DEH) participated study. Diluted administered bilateral tympanic cavity through membrane. At 24 hours post-injection, ELH evaluated Patient functions were caloric testing cVEMP....
Variants in MYH14 are reported to cause autosomal dominant nonsyndromic hereditary hearing loss (ADNSHL), with 34 variants various ethnic groups. However, the available information on prevalence, as well regard clinical features, remains fragmentary. In this study, genetic screening for was carried out using a large series of Japanese hearing-loss patients reveal more detailed information. Massively parallel DNA sequencing 68 target candidate genes applied 8074 unrelated (including 1336...
Tight junctions are cellular that play a major role in the epithelial barrier function. In inner ear, claudins, occludin, tricellulin, and angulins form bicellular or tricellular binding of membrane proteins. these, one type claudin gene, CLDN14, was reported to be responsible for human hereditary hearing loss, DFNB29. Until now, nine pathogenic variants have been reported, most phenotypic features remain unclear. present study, genetic screening 68 previously deafness causative genes...
Abstract Thyroglossal duct cysts (TGDC) are the most common type of congenital neck masses, which generally present in young adults. We a rare case giant TGDC 77-year-old patient who required atypical perioperative management. The presented with large soft mass on his anterior neck. Computed tomography showed lobulated cystic measuring 18 × 16 cm, extending from tongue base to inferior level clavicle. Because difficult intubation was expected, cyst punctured and fluid drained prior surgery....
Abstract Cochlear implants (CIs) are generally considered useful in the treatment of hereditary hearing loss with progressive deafness. Early CI can be beneficial for maintaining social activities POU4F3 mutation patients.
Cisplatin (CDDP) is widely used as an effective antineoplastic drug for cancers of various organs, and also known to cause ototoxicity. In this study, we report on the incidence factors related CDDP-induced hearing loss, time-dependent change level among these patients.Twenty patients with head neck treated chemoradiotherapy using CDDP in our institution were enrolled analyzed. As chemotherapy, three cycles concurrent administered weeks 1, 4, 7 radiotherapy. Pure-tone audiograms performed...
Cisplatin (CDDP) is widely used as an effective antineoplastic drug for cancers of various organs, and also known to cause ototoxicity. In this study, we report on the incidence factors related CDDP-induced hearing loss, time-dependent change level among these patients.
Sarcopenia, characterized by low skeletal muscle mass, and the outcome of cancer therapy are closely related based on recent research. This study aimed to evaluate correlation between mass prognosis in head neck (HNC) patients.In this study, 51 male patients with HNC treated nonsurgically January 2016 April 2018 at Shinshu University Hospital were evaluated. Skeletal was assessed using bioelectrical impedance analysis, index (SMI) calculated classify patients.The low-SMI group had a...