A5061872958- Hearing, Cochlea, Tinnitus, Genetics
- Facial Nerve Paralysis Treatment and Research
- Vasculitis and related conditions
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Vestibular and auditory disorders
- Otitis Media and Relapsing Polychondritis
- DNA and Biological Computing
- Cellular Automata and Applications
- Trigeminal Neuralgia and Treatments
- Modular Robots and Swarm Intelligence
- Ear and Head Tumors
- Nerve injury and regeneration
- Reconstructive Facial Surgery Techniques
- Tracheal and airway disorders
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Congenital Ear and Nasal Anomalies
- Airway Management and Intubation Techniques
- Infectious Diseases and Tuberculosis
- Head and Neck Anomalies
- Orthopedic Surgery and Rehabilitation
- Head and Neck Surgical Oncology
- Congenital heart defects research
Ehime University
2011-2025
Ehime University Hospital
2024
Kurume University
2017
Kitakyushu Municipal Medical Center
2017
National Hospital Organization
2017
Kumamoto City Hospital
2017
Uwajima City Hospital
2015
Weatherford College
2008
Osaka Electro-Communication University
2005-2006
Ehime Prefectural Central Hospital
2005-2006
Hearing is essential for communication, and its loss can cause a serious disruption to one’s social life. also recognized as major risk factor dementia; therefore, addressing hearing pressing global issue. Sensorineural loss, the predominant type of mainly due damage inner ear along with variety pathologies including ischemia, noise, trauma, aging, ototoxic drugs. In addition genetic factors, oxidative stress has been identified common mechanism underlying several cochlear pathologies. The...
Background/Objectives: The OTOG gene is responsible for autosomal recessive non-syndromic sensorineural hearing loss and assigned as DFNB18B. To date, 44 causative variants have been reported to cause loss. However, the detailed clinical features OTOG-associated remain unclear. Methods: In this study, we analyzed 7065 patients with (mean age 26.4 ± 22.9 years, 2988 male, 3855 female, 222 without gender information) using massively parallel DNA sequencing 158 target deafness genes. We...
Background/Objectives: Hearing loss is one of the most common sensorineural impairments, and approximately 60% early-onset cases are due to genetic variations. The otogelin-like protein, encoded by OTOGL gene, a component acellular membranes inner ear, such as tectorial membrane, thought play an important role in cochlear amplification. gene variants rare cause hearing DFNB84B, mild-to-moderate presenting early childhood with autosomal recessive inheritance. In this study, we aim enhance our...
Background: Less invasive and cost-effective alternatives are needed to manage tympanic membrane perforation (TMP). Therefore, the effectiveness of concentrated growth factors (CGF) in promoting regeneration guinea pig models eardrum was invetigeted. Methods: Large TMPs were created 34 ears using a CO2 laser divided into 3 groups: CGF-gelatin sponge (with-CGF group), saline-gelatin (without-CGF untreated group. In with-CGF group, CGF gelatin sponges implanted perforations, while without-CGF...
Severe axonal damage in the peripheral nerves results retrograde degeneration towards central side, leading to neuronal cell death, eventually resulting incomplete regeneration and functional recovery. Therefore, it is necessary evaluate facial nerve nucleus models of paralysis, investigate efficacy treatments, identify treatment options for severe paralysis. Consequently, we aimed examine percentage reduction extent which intratympanic administration a basic fibroblast growth factor (bFGF)...
Objective Basic fibroblast growth factor (bFGF) promotes the regeneration of denervated nerves. The aim this study was to evaluate regeneration‐facilitating effects novel facial nerve decompression surgery using bFGF in a gelatin hydrogel patients with severe Bell palsy. Study Design Prospective clinical study. Setting Tertiary referral center. Subjects and Methods Twenty palsy after more than 2 weeks following onset paralysis were treated new procedure. decompressed between tympanic mastoid...
The OTOA gene (Locus: DFNB22) is reported to be one of the causative genes for non-syndromic autosomal recessive hearing loss. copy number variations (CNVs) identified in this are also known cause loss, but have not been Japanese patients with Furthermore, clinical features OTOA-associated loss yet clarified. In study, we performed CNV analyses a large cohort, and CNVs 234 2262 (10.3%, 234/2262) Among CNVs, gene-related were second most frequent (0.6%, 14/2262). 14 cases, 2 individuals...
Topical application of basic fibroblast growth factor (bFGF) hydrogel facilitates faster healing from traumatic facial paralysis due to continuous release bFGF.bFGF is considered a potent agent facilitate recovery neuronal damage; however, exogenously applied bFGF does not work well because its short acting time. To enhance the effects in vivo, we developed new drug delivery system by embedding gelatin that degrades slowly. In this study, bFGF-hydrogel on nerve were investigated guinea...
Objectives: Hearing impairment (HI) in midlife may increase the risk of dementia. However, epidemiological research on association between HI and mild cognitive (MCI) is very limited. Design: The present cross-sectional study investigated relationship MCI using baseline data from Aidai Cohort Study. Study subjects were 995 Japanese adults aged 36 to 84 years. We used audiometric definition adopted by World Health Organization, which identifies speech-frequency pure-tone average hearing...
To investigate differences in immune activity based on the presence of multiple organ involvement patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and whether hearing outcomes are different between AAV localized to ear systemic AAV.Retrospective case review.University hospital.Twenty otitis media (OMAAV) who met criteria proposed by OMAAV study group Japan.Serum levels C-reactive protein, ANCA titer, soluble interleukin-2 receptor levels, outcome.Thirteen...
Background Hydrogen (H 2 ) has been reported to be effective in reducing hearing loss due several causes animal studies. However, no study examined the effectiveness of H treating humans. Thus, we investigated whether is for treatment idiopathic sudden sensorineural (ISSNHL). Materials and methods We conducted a double-blind randomized controlled trial at six hospitals between June 2019 March 2022. The protocol registration have published Japan Registry Clinical Trials (jRCT, No....
Laryngeal complications have been reported after endotracheal intubation and prone positioning in patients with critical coronavirus disease 2019 (COVID-19), but their association is unclear. In this study, we investigated the rate of laryngeal COVID-19 compared to an alternative condition (control group).
Objectives/Hypothesis Epidemiological information regarding the relationship between household income and education hearing impairment (HI) is limited. The present cross‐sectional study investigated this issue in Japan. Study Design Cross‐sectional investigation. Methods subjects were 371 men 639 women aged 36 to 84 years. A self‐administered questionnaire was used. Audiological assessment performed by pure‐tone audiometry. HI defined as who did not respond a average of >25 dB HL better...
Despite recent evidence suggesting that Bell's palsy is associated with reactivation of alfa-herpes viruses, the disease has been treated empirically, and use valacyclovir not definitively established. In 2007, two prospective, randomised, placebo-controlled trials evaluating were reported in patients palsy. One demonstrated valacyclovir/prednisolone therapy was statistically more effective than placebo/prednisolone improving recovery palsy, excluding zoster sine herpete. However,...
Conclusion: Gene analysis of facial muscle may be a promising way to detect denervation muscle, helping determine the prognosis palsy early in its progression. Objectives: In treatment intratemporal palsy, diagnosis neural damage is important deciding about therapeutic modalities. this study, we investigated relationship between severity and level myogenin expressed muscle. Methods: The animals were divided into two groups, depending on whether nerve was resected or compressed. Expression...
Tracheostomy is an important procedure for the treatment of severe coronavirus disease-2019 (COVID-19). Older age and obesity have been reported to be associated with risk COVID-19 prolonged intubation, anticoagulants are often administered in patients COVID-19; these factors also related a higher tracheostomy. Cricotracheostomy, modified opening airway through intentional partial cricoid cartilage resection, was recently useful cases low-lying larynx, obesity, stiff neck, bleeding tendency....