A5084980436- Advanced Combustion Engine Technologies
- Vehicle emissions and performance
- Biodiesel Production and Applications
- Catalytic Processes in Materials Science
- Combustion and flame dynamics
- Engineering Applied Research
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Nuclear Physics and Applications
- Nuclear physics research studies
- ECG Monitoring and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Antimicrobial Resistance in Staphylococcus
- Pulmonary Hypertension Research and Treatments
- Dental materials and restorations
- Lubricants and Their Additives
- Vibrio bacteria research studies
- Genetic Neurodegenerative Diseases
- Lipoproteins and Cardiovascular Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
Hirosaki University
2016-2025
Tokai University
2000-2025
Harvard University
2020-2024
Keio University
1993-2024
Brigham and Women's Hospital
2018-2024
Hokkaido University of Science
2024
Tokyo Women's Medical University
2005-2023
University of Oxford
2023
Niigata University
2004-2021
Municipal Tsuruga Hospital
2012-2021
Both osteopontin (OPN) and galectin-3 have been implicated in phagocytic clearance of dead cells reparative fibrosis during wound healing. CD206+ macrophages are involved tissue repair through phagocytosis after myocardial infarction (MI). However, the relationship among OPN, galectin-3, macrophage polarization context MI remains unclear.The time course Spp1 (encoding OPN) expression heart showed a strong activation on day 3 MI. To identify where body which transcriptional activity increased...
Patients with rare conditions such as cardiac amyloidosis (CA) are difficult to identify, given the similarity of disease manifestations more prevalent disorders. The deployment approved therapies for CA has been limited by delayed diagnosis this disease. Artificial intelligence (AI) could enable detection diseases. Here we present a pipeline using AI models electrocardiograms (ECG) or echocardiograms inputs. These models, trained and validated on 3 5 academic medical centers (AMC)...
Sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce progression of chronic kidney disease and the risk cardiovascular morbidity mortality in a wide range patients. However, their effects on some patients with are unclear because few clinical outcomes occurred among such completed trials. In particular, guidelines stratify level recommendation about who should be treated SGLT2 based diabetes status albuminuria. We aimed to assess empagliflozin both overall specific types participants...
Abstract Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD) that adversely affects prognosis. Despite guideline recommendations, only half of the patients undergo surveillance echocardiograms. An AI model detecting reduced left ventricular ejection fraction from 12-lead electrocardiograms (ECG) (AI-EF model) suggests ECG features reflect pathophysiology. We hypothesized could predict CTRCD baseline ECG, leveraging AI-EF model’s insights, and developed AI-CTRCD using...
Background/Objectives: The OTOG gene is responsible for autosomal recessive non-syndromic sensorineural hearing loss and assigned as DFNB18B. To date, 44 causative variants have been reported to cause loss. However, the detailed clinical features OTOG-associated remain unclear. Methods: In this study, we analyzed 7065 patients with (mean age 26.4 ± 22.9 years, 2988 male, 3855 female, 222 without gender information) using massively parallel DNA sequencing 158 target deafness genes. We...
Background Patient with acute coronary syndrome benefits from early revascularization. However, methods for the selection of patients who require urgent revascularization a variety visiting emergency room chest symptoms is not fully established. Electrocardiogram an easy and rapid procedure, but may contain crucial information recognized even by well-trained physicians. Objective To make prediction model needs 12-lead electrocardiogram recorded in room. Method We developed artificial...
Background: Novel targeted treatments increase the need for prompt hypertrophic cardiomyopathy (HCM) detection. However, its low prevalence (0.5%) and resemblance to common diseases present challenges that may benefit from automated machine learning–based approaches. We aimed develop learning models detect HCM differentiate it other cardiac conditions using ECGs echocardiograms, with robust generalizability across multiple cohorts. Methods: Single-institution ECG were trained validated on...
The EMPA-KIDNEY trial showed that empagliflozin reduced the risk of primary composite outcome kidney disease progression or cardiovascular death in patients with chronic mainly through slowing progression. We aimed to assess how effects might differ by across its broad population.
Abstract Aims Available predictive models for sudden cardiac death (SCD) in heart failure (HF) patients remain suboptimal. We assessed whether the electrocardiography (ECG)-based artificial intelligence (AI) could better predict SCD, and also combination of ECG-AI index conventional predictors SCD would improve stratification among HF patients. Methods results In a prospective observational study, 4 tertiary care hospitals Tokyo enrolled 2559 hospitalized who were successfully discharged...
Protein carbonyls are reported to increase in aging and pathologies such as Alzheimer's disease ischemic injury. Detailed study of this important issue has, however, been hampered by lack an appropriate method identify individual carbonylated proteins. We describe here immunoblot investigate protein reactive 2,4-dinitrophenyl hydrazine. Rabbit polyclonal antibodies against hydrazine were used the proteins derivatized reagent one- or two-dimensional polyacrylamide gel electrophoresis followed...
Background: Patients with crowned dens syndrome typically present severe neck pain and have calcium deposits around the odontoid process of axis on radiographs. To our knowledge, cases only thirty-five patients been reported in English-language literature clinical features remain unclear. The purposes this study were to examine syndrome, determine treatment outcomes, propose diagnostic criteria. Methods: Forty had deposition computed tomography scans, they thus diagnosed as having syndrome....
FK 749 is a new parenteral cephalosporin derivative which more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and Serratia marcescens, than cephalosporins cephamycins cefotiam, cefamandole, cefuroxime, cefotaxime, cefmetazole. was especially organisms resistant to these related antibiotics. potent in bactericidal activity other antibiotics, clearly enhanced presence of 90% defibrinated rabbit blood. The...
The pathogenesis of heart failure with preserved ejection fraction (HFpEF) in obese diabetic patients has been implicated metainflammation. Increased expression inducible nitric oxide synthase (iNOS) and dysfunction the unfolded protein response (UPR), especially inositol-requiring enzyme 1α-X-box binding 1 (IRE1α-Xbp1s) signaling heart, have associated HFpEF. We investigated effect imeglimin, a potential new treatment for type 2 diabetes, on induced obesity, impaired glucose tolerance,...
The membrane components of cardiomyocytes are rich in polyunsaturated fatty acids, which easily oxidized. Thus, an efficient glutathione-based lipid redox system is essential for maintaining cellular functions. However, the relationship between disruption during ischemia-reperfusion (IR), oxidized production, and consequent cell death (ferroptosis) remains unclear. We investigated mechanisms underlying glutathione-mediated reduction related to ferroptosis IR developed intervention strategies...
FK 027 was more active than cefaclor, cephalexin, and amoxicillin against stock strains of a wide variety gram-negative bacteria, including such opportunistic pathogens as Citrobacter Enterobacter species Serratia marcescens. significantly the three reference drugs clinical isolates Escherichia coli, Klebsiella pneumoniae, indole-positive -negative Proteus species, Providencia Haemophilus influenzae, Neisseria gonorrhoeae. It less staphylococci, but it similar to cefaclor in its activity...
More than 70 characters of 55 strains Achromobacter xylosoxidans were compared with those the type strain A. xylosoxidans, ATCC 27061 (= KM 543). Repeated examination these confirmed stability flagellar morphology and biochemical reaction pattern performed that species can be recognized by characters. Two Alcaligenes faecalis, two denitrificans, five sp., each King groups IIIa IIIb identified as xylosoxidans. The base compositions deoxyribonucleic acids 20 are given. cellular fatty acid...
Musician's dystonia is a task-specific movement disorder that causes twisting or repetitive abnormal finger postures and movements, which tend to occur only while playing musical instruments. Such will probably lead termination of the careers affected professional musicians. Most currently available treatments have yet provide consistent satisfactory results. We present long-term follow-up results ventro-oral thalamotomy for 15 patients with musician's dystonia.Between October 2003 September...