A5039268119- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Public Health
- Cardiac Imaging and Diagnostics
- Combustion and flame dynamics
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Infectious Diseases and Mycology
- Colorectal Cancer Screening and Detection
- ECG Monitoring and Analysis
- Case Reports on Hematomas
- Spinal Dysraphism and Malformations
- Heart Failure Treatment and Management
- Reproductive biology and impacts on aquatic species
- Appendicitis Diagnosis and Management
- Multiple and Secondary Primary Cancers
- Artificial Intelligence in Healthcare
- Bladder and Urothelial Cancer Treatments
Keio University Hospital
2019-2025
Keio University
2019-2024
Shinshu University
2004-2023
Ōtani University
2007
Gifu University
2003
Kyoto Prefectural University of Medicine
1990-1993
Cancer Institute (WIA)
1990
Juntendo University
1983
Versican is an evolutionary conserved extracellular matrix proteoglycan, and versican expression loss in mice results embryonic lethality owing to cardiovascular defects. However, the utero development of mammals limits our understanding precise role during development. Therefore, use evolutionarily distant species that develop ex more suitable for studying mechanistic basis activity. We performed ENU mutagenesis screening identify medaka mutants with defects In this study, we described a...
The ontogenetic development of gonads from embryo to adult was observed histologically in the viviparous teleost, Gambusia affinis. Primordial germ cells (PGCs) appeared subendodermal space 14 days before birth, and then transferred dorsal mesentery form paired genital ridges 12 birth. PGCs proliferated ridge, forming gonadal primordia 10 All differentiated ovary containing oocytes 2 but redifferentiated testis just after This indicates that mosquitofish is a juvenile hermaphroditic species....
Background Atrial fibrillation and heart failure (HF) possess mutual risk factors share a common pathophysiological pathway. Tricuspid regurgitation (TR) is known predictor of adverse events in patients with HF. However, its implications on atrial early stage remain unknown. Methods Results Data 2211 without previous HF diagnosis were extracted from prospective, multicenter registry newly diagnosed fibrillation. TR was categorized as absent, mild, moderate, severe based the American Society...
Background Catheter ablation (CA) for atrial fibrillation (AF) is preferred paroxysmal AF (PAF) but selectively performed in patients with persistent (PersAF). This study aimed to investigate the prognostic differences and consequences of CA based on type. Methods Results Data from a multicenter cohort were analyzed, categorizing as PAF or PersAF according duration (≤7 >7 days, respectively). A composite all-cause death, heart failure hospitalization, stroke, bleeding events during 2-year...
We report a case with concurrent ingestion of carbamazepine (CBZ) overdose and grapefruit juice. A 23-year-old man, history epilepsy, was admitted to our emergency department 2 h after ingesting 10 g CBZ 1 L On arrival, the patient's Glasgow Coma Scale score 9 he showed signs restlessness. Grapefruit juice-like gastric fluid, tablet residue, observed in his stomach we inserted tube. Our initial test detected blood level 41.5 mg/L.We treated patient lavage, activated charcoal, charcoal...
Abstract Background A novel measurement of the local impedance (LI) and electrograms recorded from micro‐electrodes on catheter tip has been developed. However, data during pulmonary vein (PV) ablation is not sufficient. We aimed to investigate utility this initial atrial fibrillation (AF) ablation. Methods investigated 111 representative radiofrequency applications in 7 AF patients without a history prior (6 males, age 68 [65‐72] years, 2 persistent AF). The strategy was PV isolation for...
Abstract Introduction An electrical superior vena cava (SVC) isolation from the right atrium (RA) sometimes can be challenging. For a safe and efficient SVC isolation, we aimed to visualize accurate position of SVC‐RA junction on three‐dimensional (3D) mapping system using decremental conduction properties in patients with atrial fibrillation (AF). Methods This study consisted 15 consecutive AF (11 males, age 59 ± 10 years). A 3D catheter was positioned region while delivering single...
A 62-year-old female had suffered from recurrent syncopal episodes triggered by physical and emotional stress since childhood. She no family history of sudden death. An intensive examination could not detect any structural disease, exercise testing provoked polymorphic ventricular ectopy followed tachycardia accompanied with syncope leading to a diagnosis catecholaminergic (CPVT). genetic analysis next generation sequencer identified homozygous W361X mutation in the CASQ2 gene. Careful...
The anatomical changes in pulmonary veins (PVs) after cryoballoon ablation (CBA) are unclear. We aimed to determine the morphological PVs and left atrium (LA) along with predictive factors for clinical PV stenosis.We analyzed data of 320 from 80 patients who underwent CBA atrial fibrillation (age: 62 ± 10 years, 59 males). All pre- post-procedural cardiac computed tomography. defined stenosis when cross-sectional area decreased by more than 50%.The average ostial LA volume significantly...
The Apple Watch can notify users of irregular heart rhythms and potential atrial fibrillation (AF). However, the time delay between notification electrocardiogram (ECG) recording may cause a failure in disease diagnosis.
Background: Current clinical practice guidelines for atrial fibrillation (AF) recommend stroke risk stratification and the use of oral anticoagulants (OACs) patients at risk. However, physicians’ recognition patients’ may differ from calculated risk, effect this discrepancy on subsequent care remains unknown. Aims: We aimed to document treating estimations individual patients' assess its association with OAC utilization. Methods: A multicenter, prospective cohort study was conducted in two...
Abstract A 23‐year‐old female had been suffering from recurrent syncopal episodes during sleep since her childhood. She a family history of sudden death and QTc interval was remarkably prolonged to 537 ms Holter ECG revealed torsade de pointes, corresponding syncope. started on mexiletine shortened. Her symptoms were controlled after β‐blockers Ca‐blockers added. genetic analysis with next generation sequencer identified frameshift mutation at the C terminus KCNH2 gene. Here we present type...
Background: Atrial septal defect (ASD) increases the risk of heart failure, arrhythmias, pulmonary hypertension, and stroke. In most cases, these risks could be reduced by minimally invasive percutaneous closure. However, since ASD is largely underdiagnosed due to subtle symptoms examination findings, a screening strategy for improved early detection essential.We soughttodetect using single recording 12-lead electrocardiography (ECG) utilizingconvolutionalneural network (CNN). Methods: A...
Definitive diagnosis of familial hypercholesterolemia (FH) is paramount for the risk management patients and their relatives. The present study aimed to investigate frequency gene variants contributing low-density lipoprotein cholesterol (LDL-C) metabolism clinical relevance in with early-onset coronary artery disease (EOCAD). Among 63 consecutive EOCAD (men <55 years or women <65 years) who underwent percutaneous intervention (PCI) from 2013 2019 at Keio University Hospital, 52 consented...
Abstract Aims Linear lesions are routinely created by radiofrequency catheter ablation. Unwanted electrical conduction gaps can be produced and often difficult to ablate. This study aimed clarify the characteristics of during atrial fibrillation ablation analysing bidirectional activation maps using a high-density mapping system (RHYTHMIA). Methods results retrospective included 31 patients who had along pulmonary vein (PV) isolation or box lesions. Activation were sequentially pacing from...