A5006358902- Hearing, Cochlea, Tinnitus, Genetics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Hearing Loss and Rehabilitation
- Cardiac pacing and defibrillation studies
- Gallbladder and Bile Duct Disorders
- RNA regulation and disease
- Cardiac Health and Mental Health
- Connexins and lens biology
- Pancreatic and Hepatic Oncology Research
- Biochemical Analysis and Sensing Techniques
- Ion Channels and Receptors
- Pediatric Hepatobiliary Diseases and Treatments
- Ear Surgery and Otitis Media
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Thermoregulation and physiological responses
- Hair Growth and Disorders
- Skin and Cellular Biology Research
- Developmental Biology and Gene Regulation
Tokyo Metropolitan Institute of Medical Science
2011-2024
Keio University
2021-2024
Tottori University
2023-2024
Keio University Hospital
2021-2023
Institute for Sports Medicine
2023
Saitama Municipal Hospital
2020
Tokyo University of Agriculture
2010-2011
The lactate threshold (LT1), which is defined as the first rise in concentration during incremental exercise, has not been non-invasively and conveniently determined a clinical setting. We aimed to visualize changes sweat exercise using our wearable sensor investigate relationship between (LT1) ventilatory (VT1). Twenty-three healthy subjects 42 patients with cardiovascular diseases (CVDs) were enrolled. During dynamic values visualized real-time sharp continuous increase up volitional...
Most clinical reports have suggested that patients with congenital profound hearing loss recessive mutations in deafness genes, whereas dominant alleles are associated progressive (PHL). Jackson shaker (Ush1gjs) is a mouse model of exhibits caused by the homozygous mutation Ush1g/Sans on chromosome 11. We found C57BL/6J-Ush1gjs/+ heterozygous mice exhibited early-onset PHL (ePHL) accompanied degeneration stereocilia cochlear outer hair cells. Interestingly, ePHL did not develop mutant...
A simple method for determining the anaerobic threshold in patients with heart failure (HF) is needed. This prospective clinical trial (LacS-001) aimed to investigate safety of a sweat lactate-monitoring sensor and correlation between lactate (sLT) ventilatory (VT). To this end, we recruited 50 HF New York Heart Association functional classification I–II (mean age: 63.5 years, interquartile range: 58.0–72.0). Incremental exercise tests were conducted while monitoring levels using our sensor....
An unconventional myosin encoded by the VI gene (MYO6) contributes to hearing loss in humans. Homozygous mutations of MYO6 result nonsyndromic profound congenital loss, DFNB37. Kumamoto shaker/waltzer (ksv) mice harbor spontaneous mutations, and homozygous mutants exhibit defects balance caused fusion stereocilia. We identified a Myo6c.1381G>A mutation that was found be p.E461K leading alternative splicing errors Myo6 mRNA ksv mutants. analysis protein expression animals harboring this...
We aimed to investigate the reliability and validity of sweat lactate threshold (sLT) measurement based on real-time monitoring transition in levels (sLA) under hypoxic exercise. In this cross-sectional study, 20 healthy participants who underwent exercise tests using respiratory gas analysis hypoxia (fraction inspired oxygen [FiO2], 15.4 ± 0.8%) addition normoxia (FiO2, 20.9%) were included; we simultaneously monitored sLA a wearable sensor. The initial significant elevation over baseline...
Background Catheter ablation (CA) for atrial fibrillation (AF) is preferred paroxysmal AF (PAF) but selectively performed in patients with persistent (PersAF). This study aimed to investigate the prognostic differences and consequences of CA based on type. Methods Results Data from a multicenter cohort were analyzed, categorizing as PAF or PersAF according duration (≤7 >7 days, respectively). A composite all-cause death, heart failure hospitalization, stroke, bleeding events during 2-year...
The coat of a goat, like that many mammalian species, consists an outer coarse hairs and under fine, downy hairs. guard are produced by primary follicles the finer cashmere secondary follicles. We previously reported hair keratins components hair, proteomic analysis revealed their expression is elevated in winter hair. To determine detailed characterization, we have cloned keratin 33A gene, major highly expressed winter, then analyzed goat coat. By Western analysis, detected protein only...
In humans, hearing is a major factor in quality of life. Mouse models are important tools for the discovery genes responsible genetic loss, often enabling analysis processes that regulate onset deafness humans. Thus far, at least 400 mutants have been discovered laboratory mouse populations and used study deafness. Here we report new spontaneous recessive Rinshoken shaker/waltzer (rsv) mutant derived from our in-house C57BL/6J stock, which exhibits circling and/or head-tossing behaviour...
Exercise therapy for cardiovascular disease (CVD) is mainly evaluated based on the heart rate (HR) or Borg scale. However, these indices can be unreliable depending patient's medication their subjective decisions; thus, alternative methods are required easier and safer implementation of aerobic exercise. Here, we examined whether real-time analysis HR variability (HRV) help maintain exercise intensity at ventilatory threshold (VT) during
Abstract Background A novel measurement of the local impedance (LI) and electrograms recorded from micro‐electrodes on catheter tip has been developed. However, data during pulmonary vein (PV) ablation is not sufficient. We aimed to investigate utility this initial atrial fibrillation (AF) ablation. Methods investigated 111 representative radiofrequency applications in 7 AF patients without a history prior (6 males, age 68 [65‐72] years, 2 persistent AF). The strategy was PV isolation for...
Pathological examination by endoscopic ultrasound-fine needle aspiration is not possible in approximately 10% of pancreatic tumor cases. Pancreatic juice cytology (PJC) considered an alternative diagnostic method. However, its capability insufficient, and PJC has been repeatedly redevised. Serial cytological (SPACE) secretin-loaded (S-PJC) have recently introduced as methods. This study aimed to determine the capacity safety SPACE S-PJC using a propensity score-matched analysis. The...
Abstract Aims Linear lesions are routinely created by radiofrequency catheter ablation. Unwanted electrical conduction gaps can be produced and often difficult to ablate. This study aimed clarify the characteristics of during atrial fibrillation ablation analysing bidirectional activation maps using a high-density mapping system (RHYTHMIA). Methods results retrospective included 31 patients who had along pulmonary vein (PV) isolation or box lesions. Activation were sequentially pacing from...
The age-related hearing loss allele (Cdh23ahl) of the cadherin 23 gene leads to a more severe phenotype through additive effects with risk alleles for loss. In this study, we genome edited Cdh23ahl wild-type Cdh23+ in outbred ICR mice and inbred NOD/Shi established from investigated their on phenotypes. Several tests confirmed that developed early onset high-frequency exhibited individual differences times. Severe cochlear hair cells was also detected areas mice. These phenotypes were...
An MSM/Ms strain was established using Japanese wild mice, which exhibit resistance to several phenotypes associated with aging, such as obesity, inflammation, and tumorigenesis, compared common inbred mouse strains. is resistant age-related hearing loss, their auditory abilities are sustained for long durations. The loss 3 (ahl3) locus contributes in strain. We generated ahl3 congenic strains by transferring a genomic region on chromosome 17 from mice into C57BL/6J mice. Although develop...
Abstract Outer hair cells (OHCs) are responsible for the amplification of sound, and death these leads to hearing loss. Although mechanisms sound OHC have been well investigated, effects on cochlea after poorly understood. To study consequences death, we established an knockout system using a novel mouse model, Prestin - hDTR , which uses prestin promoter express human diphtheria toxin (DT) receptor gene ( ). Administration DT adult mice results in depletion almost all OHCs without...
Background: Exercise therapy for cardiovascular disease (CVD) is mainly evaluated based on the heart rate or Borg scale. However, these indices can be unreliable depending patient’s medication their arbitrary decisions; thus, alternative methods are required easier implementation of aerobic exercise. Here, we examined whether real-time analysis variability (HRV) help maintain exercise intensity at ventilatory threshold (VT) during exercise.Methods: Twenty-eight patients with CVD treated Keio...
(1) Background: There is controversy regarding stent placement for unresectable malignant hilar biliary obstruction (UMHBO). We mainly use the partial stent-in-stent (PSIS) method with an uncovered self-expandable metallic (UCSEMS) based on drainage area and patency period. In this study, we investigated usefulness safety of PSIS method. (2) Methods: total, 59 patients who underwent UMHBO at our hospital were included in study. The technical success rate, clinical time to recurrent (TRBO)...
: Although peroral cholangioscopy has improved the endoscopic treatment of difficult stones, intrahepatic stones remains challenging. The incidence cholangitis is high when used to treat stones. This study aimed investigate efficacy and safety with for common bile duct
An unconventional myosin, myosin VI gene (MYO6), contributes to recessive and dominant hearing loss in humans mice. The Kumamoto shaker/waltzer (ksv) mouse is a model of deafness resulting from splice-site mutation Myo6. While ksv/ksv homozygous mice are deaf due cochlear hair cell stereocilia fusion at the neonatal stage, phenotypes ksv/+ heterozygous have been less clear. Due this splicing error, most MYO6 protein expression lost ksv mice; however, with single amino acid (p.E461K) remains...
Early detection of atrial fibrillation (AF) is important. Japan has a universal screening system, and regular health (HS) available to support AF without hospital visit. However, health-related outcomes other characteristics HS-detected conventionally diagnosed remain unknown.That the patients with may differ from those whose was detected by procedures.In total, 3318 consecutive newly referred cases were enrolled; demographic clinical compared between two groups created based on mode (the HS...