A5035367779- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Diabetes Treatment and Management
- Metabolism and Genetic Disorders
- Trauma Management and Diagnosis
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Risk Factors
- Healthcare Systems and Public Health
- Atherosclerosis and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Acute Kidney Injury Research
Saint Luke's Hospital
2022-2025
University of Missouri–Kansas City
2022-2025
Keio University
2016-2025
United States University
2025
Heart Institute
2024
Keio University Hospital
2020-2024
Health Innovations (United States)
2024
Jikei University School of Medicine
2021-2023
Cardiovascular Research Foundation
2023
Clinical Research Institute
2017
An accurate prediction of major adverse events after percutaneous coronary intervention (PCI) improves clinical decisions and specific interventions. To determine whether machine learning (ML) techniques predict peri-PCI [acute kidney injury (AKI), bleeding, in-hospital mortality] with better discrimination or calibration than the National Cardiovascular Data Registry (NCDR-CathPCI) risk scores, we developed logistic regression gradient descent boosting (XGBoost) models for each outcome...
<h3>Importance</h3> The clinical characteristics and outcomes of women men with atrial fibrillation (AF) are reported to be different. However, whether sex-related differences extend patients' symptom burden perceived quality life (QOL) or the management pattern AF has been rarely studied, particularly in Asian countries. <h3>Objective</h3> To assess symptoms, treatment, QOL between Japanese female male patients AF. <h3>Design, Setting, Participants</h3> Retrospective cohort study using data...
<h3>Importance</h3> Prasugrel was approved at a lower dose in 2014 Japan than the West because East Asian patients are considered more susceptible to bleeding Western patients. However, real-world outcomes with low-dose prasugrel treatment remain unclear. <h3>Objective</h3> To investigate association of vs standard-dose clopidogrel administration short-term among acute coronary syndrome undergoing percutaneous intervention (PCI). <h3>Design, Setting, and Participants</h3> This study used...
Abstract Aims The usefulness of catheter ablation (CA) for atrial fibrillation (AF) across a broad spectrum heart failure (HF) patients remains to be established. We assessed the association CA with both health-related quality life (QoL) and cardiovascular events among HF reduced preserved left ventricular ejection fraction (LVEF) in an ‘all-comer’ outpatient-based AF registry. Methods results Of 3303 consecutively enrolled retrospective multicentre registry that mandated Atrial Fibrillation...
A primary objective in managing atrial fibrillation (AF) is to optimize patients' health status, which can be done only if physicians accurately quantify the outcomes associated with AF lives.
Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective Keio interhospital Cardiovascular Studies-atrial (KiCS-AF) registry to clarify baseline QOL profiles patients at time initial referral identify areas for improvement country-specific gaps. Participants KiCS-AF a multicentre, prospective cohort study...
Objective— Transforming growth factor-β inhibits migration and proliferation of endothelial smooth muscle cells. Endoglin is a transmembrane receptor for transforming factor-β1 factor-β3. released into blood as soluble form (soluble endoglin [sEng]), but plasma sEng levels in patients with coronary artery disease (CAD) have not been elucidated. Approach Results— We measured 244 undergoing angiography. The severity atherosclerosis was evaluated the numbers >50% stenotic vessels segments....
BackgroundNon-vitamin K antagonist oral anticoagulants (NOACs) have been widely used to prevent stroke in non-valvular atrial fibrillation (NVAF) patients. Stringent monitoring is not required for NOACs, albeit dose adjustments are needed based on specific patient factors, such as renal function, body weight and age, or concomitant medications. We investigated the NOAC dosing patterns evaluated predictors of non-standardized reduction (NSDR).MethodsA total 2452 newly diagnosed NVAF patients...
Door-to-balloon (DTB) time ≤90 min is an important quality indicator in the management of ST-elevation myocardial infarction (STEMI), but a considerable number patients still do not meet this goal, particularly countries outside USA and Europe.Methods Results:We analyzed 2,428 STEMI who underwent primary PCI ≤12 h symptom onset were registered ongoing prospective multicenter database (JCD-KiCS registry), between 2008 2013. We both trend DTB within cohort registry, independent predictors...
Measuring the quality of care has been central for improving outcomes patients undergoing percutaneous coronary intervention (PCI). This study described performance rates and regional variations in metrics PCI using a representative national Japanese registry.
Background Atrial fibrillation and heart failure (HF) possess mutual risk factors share a common pathophysiological pathway. Tricuspid regurgitation (TR) is known predictor of adverse events in patients with HF. However, its implications on atrial early stage remain unknown. Methods Results Data 2211 without previous HF diagnosis were extracted from prospective, multicenter registry newly diagnosed fibrillation. TR was categorized as absent, mild, moderate, severe based the American Society...
BACKGROUND: Pursuing initial invasive or conservative management of chronic coronary disease (CCD) is a preference-sensitive decision that should include shared decision-making. Communicating the benefits either approach challenging, as individual patients rarely achieve population-averaged outcomes reported in clinical trials. Our objective was to develop patient aid (PDA) with patient-specific estimates for versus CCD, based on ISCHEMIA trial (International Study Comparative Health...
Background Although they are fast‐growing populations in the United States, little is known about survival outcomes of Hispanic and Asian patients after in‐hospital cardiac arrest. Methods Results In Get With The Guidelines–Resuscitation, we identified Asian, Hispanic, White adults with arrest during 2005 to 2023. Using multivariable models, compared rates discharge separately for versus patients, as well sustained return spontaneous circulation ≥20 minutes favorable neurologic secondary...
Background Catheter ablation (CA) for atrial fibrillation (AF) is preferred paroxysmal AF (PAF) but selectively performed in patients with persistent (PersAF). This study aimed to investigate the prognostic differences and consequences of CA based on type. Methods Results Data from a multicenter cohort were analyzed, categorizing as PAF or PersAF according duration (≤7 >7 days, respectively). A composite all-cause death, heart failure hospitalization, stroke, bleeding events during 2-year...