A5105510860- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Cardiac electrophysiology and arrhythmias
- Atherosclerosis and Cardiovascular Diseases
- Nutrition and Health in Aging
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cytokine Signaling Pathways and Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Hormonal Regulation and Hypertension
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Protease and Inhibitor Mechanisms
- Nitric Oxide and Endothelin Effects
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Fibroblast Growth Factor Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Takotsubo Cardiomyopathy and Associated Phenomena
- Frailty in Older Adults
- Adipokines, Inflammation, and Metabolic Diseases
- Pulmonary Hypertension Research and Treatments
National Defense Medical College
2021-2024
Tokyo Medical Center
2013-2022
National Hospital Organization
2013-2022
National Defense Medical College Hospital
2021
Utsunomiya University
2016
Ochanomizu University
2016
Toyo University
2016
Keio University
2005-2010
Health and Human Development (2HD) Research Network
2010
National Center For Child Health and Development
2008
Stem cell therapy can help repair damaged heart tissue. Yet many of the suitable cells currently identified for human use are difficult to obtain and involve invasive procedures. In our search novel stem with a higher cardiomyogenic potential than those available from bone marrow, we discovered that potent cardiac precursor-like be harvested menstrual blood. This represents new, noninvasive, source therapeutic material. We demonstrate blood-derived mesenchymal (MMCs) began beating...
Rationale : Amniotic membrane is known to have the ability transdifferentiate into multiple organs and expected stimulate a reduced immunologic reaction. Objective Determine whether human amniotic membrane–derived mesenchymal cells (hAMCs) can be an ideal allograftable stem cell source for cardiac regenerative medicine. Methods Results We established hAMCs. After cardiomyogenic induction in vitro, hAMCs beat spontaneously, calculated transdifferentiation efficiency was 33%. Transplantation...
We tested the cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs). Both number and function may be depressed in senile patients with severe coronary risk factors. Therefore, obtained from such not well. For this reason, UCBMSCs are potentially a new cell source for cell-based therapy, since can younger populations being routinely utilized clinical patients. The (5 x 10(3) per cm(2)) were cocultured fetal murine cardiomyocytes ([CM] 1 10(5) cm(2))....
Abstract Media with high concentrations of serum are commonly used to induce cardiomyogenic transdifferentiation in mesenchymal stem cells; however, contains numerous unknown growth factors and interferes definition specific secreted from feeder cells. In the present study, we determined whether human cells can be observed a FBS‐free medium. The efficiency was 10% FBS‐containing standard medium (10%FBS) containing insulin thyroxin (FBS‐free). uterine endometrium‐derived (EMC100, EMC214)...
Green tea and coffee contain various bioactive compounds (e.g., polyphenols), their consumption has been proposed to decrease the risk of cardiovascular diseases. Here, we investigated associations between green that prevalence coronary artery disease (CAD) in Japanese patients. The study group was 612 patients who underwent angiography at Tokyo Medical Center July 2008 February 2017. CAD confirmed 388 patients: one-vessel (1-VD, n=166); two-vessel (2-VD, n=112); three-vessel (3-VD, n=110)....
Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) show cardiovascular protective effects, regardless of the patient’s history diabetes mellitus (DM). SGLT2is suppressed adverse events in patients with type 2 DM, and furthermore, SGLT-2is reduced risk worsening heart failure (HF) or death HF. Along these research findings, are recommended for HF latest guidelines. Despite benefits, concern surrounding increasing body weight loss other has not yet been resolved, especially sarcopenia...
Biological sex is one of the major factors characterizing heart failure (HF) patient phenotype. Understanding sex-related differences in HF crucial to implement personalized care for patients with various phenotypes. There are left ventricular (LV) remodeling patterns setting, namely, more likely concentric and diastolic dysfunction women eccentric systolic men. Recently supra-normal EF (snLVEF) has been recognized as a risk worse outcome. This pathology might be relevant female patients....
Objective— Transforming growth factor-β inhibits migration and proliferation of endothelial smooth muscle cells. Endoglin is a transmembrane receptor for transforming factor-β1 factor-β3. released into blood as soluble form (soluble endoglin [sEng]), but plasma sEng levels in patients with coronary artery disease (CAD) have not been elucidated. Approach Results— We measured 244 undergoing angiography. The severity atherosclerosis was evaluated the numbers >50% stenotic vessels segments....
Aims . Atherosclerotic disease, such as coronary artery disease (CAD), is recognized to be associated with inflammation and oxidative stress. We investigated the association between CAD plasma levels of sestrin2 which one stress-inducible antioxidant proteins. Methods measured in 304 patients undergoing elective angiography. The severity was represented numbers >50% stenotic vessels segments score. Results found 175 patients, whom 73 had 1-vessel (1-VD), 59 2-vessel (2-VD), 43 3-vessel...
Aims . Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron. Since these products have antiatherogenic properties, HO-1 may play a protective role against progression atherosclerosis. However, plasma levels in patients with atherosclerotic diseases, such as coronary artery disease (CAD) peripheral (PAD), not been clarified yet. Methods We investigated by ELISA 410 consecutive undergoing elective angiography who also had...
The long-term prognostic value of the bioavailability L-arginine, an important source nitric oxide for maintenance vascular endothelial function, has not been investigated fully. We therefore relationship between amino acid profile and prognosis in patients with a history standby coronary angiography.We measured serum concentrations L-citrulline, L-ornithine by high-speed liquid chromatography. examined L-arginine/L-ornithine ratio incidence all-cause death, cardiovascular major adverse...
Background:Intracardiac echocardiography (ICE) and cardiac computed tomography (CCT), in addition to standard transesophageal (TEE), have been used identify left atrial (LA) thrombi prior ablation for fibrillation (AF). The clinical advantages of this, however, remain unclear. This study therefore investigated the additional pre-procedural LA appendage (LAA) thrombus evaluation using ICE value CCT persistent long-standing AF.
Aim: Betatrophin, a recently identified circulating adipokine, affects lipid and glucose metabolism. However, association between plasma betatrophin levels atherosclerotic diseases, such as coronary artery disease (CAD) peripheral (PAD), has not been elucidated.
Fibroblast growth factor-21 (FGF-21) is a metabolic regulator with beneficial effects on glucolipid metabolism. Since FGF-21 has lipid-lowering, anti-inflammatory and anti-oxidant properties, it may play protective role against atherosclerosis. However, blood levels in coronary artery disease (CAD) or peripheral (PAD) have not been elucidated.
Background:Preprocedural dual antiplatelet therapy (DAPT) in percutaneous coronary interventions (PCI) has been shown to improve outcomes; however, the efficacy of procedure and its complications Japanese patients remain largely unexplored, so we examined risks benefits DAPT before PCI association with in-hospital outcomes.Methods Results:We analyzed data from who had undergone at 12 centers within metropolitan Tokyo area between September 2008 2013.Our study group comprised 6,528 patients,...
Interleukin (IL)-27, one of cytokines in the IL-12 family, is considered to have both pro- and anti-inflammatory properties. However, blood IL-27 levels coronary artery disease (CAD) not been fully elucidated yet. This cross-sectional study was done elucidate association between CAD. We investigated plasma high-sensitivity C-reactive protein (hsCRP) 274 consecutive patients who underwent elective angiography for suspected CAD present 177 [30 acute syndrome (ACS) 147 stable CAD]. Compared...