A5050286894- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Palliative Care and End-of-Life Issues
- Cardiac Health and Mental Health
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Potassium and Related Disorders
- Cardiovascular Effects of Exercise
- Diabetes Treatment and Management
- Cardiovascular Issues in Pregnancy
- Cardiac electrophysiology and arrhythmias
- Sleep and related disorders
- Acute Myocardial Infarction Research
- Vascular Anomalies and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Congenital Heart Disease Studies
- Obstructive Sleep Apnea Research
- Family and Patient Care in Intensive Care Units
Kyorin University
2015-2025
Kyorin University Hospital
2020-2025
The University of Tokyo
2015-2024
Keio University
2014-2023
Shibuya University Network
2022-2023
Keio University Hospital
2018-2020
RELX Group (United States)
2019
Chiba University
2016
Impact
2016
Institute of Cardiology
2016
Rationale: In-hospital outcomes are generally acceptable in patients with type B dissection; however, some present undesirable complications, such as aortic expansion and rupture. Excessive inflammation is an independent predictor of adverse clinical outcomes. Objective: We have investigated the underlying mechanisms catastrophic complications after acute dissection (AAD) mice. Methods Results: When angiotensin II was administered lysyl oxidase inhibitor–preconditioned mice, AAD emerged...
AimsHigh-mobility group box 1 protein (HMGB1) is one of the recently defined damage-associated molecular pattern molecules derived from necrotic cells and activated macrophages. We investigated clinical implications serum HMGB1 elevation in patients with acute myocardial infarction (MI). Then, we evaluated effect blockade on post-MI left ventricular (LV) remodelling a rat MI model.
Abstract Aims Predictive models for heart failure patients are widely used in the clinical practice to stratify patients' mortality and enable clinicians tailor intensify their approach. However, such have not been validated internationally. In addition, biomarkers now frequently measured obtain prognostic information, implications of this known. study, we aimed validate model performance Meta‐analysis Global Group Chronic Heart Failure (MAGGIC) score a Japanese acute registry further...
SA-I, SA-II *The morphofunctional phenotype description (M) may contain more information using standard abbreviations, such as AVB, atrioventricular block; WPW, Wolff-Parkinson-White syndrome; LQT, prolongation of the QT interval; AF, atrial fibrillation; ↓R, low electrocardiogram voltages; ↓PR, short PR interval.† Organ (O) involvement in addition to H subscript (for heart) should be expanded for M
Abstract Aims Available predictive models for sudden cardiac death (SCD) in heart failure (HF) patients remain suboptimal. We assessed whether the electrocardiography (ECG)-based artificial intelligence (AI) could better predict SCD, and also combination of ECG-AI index conventional predictors SCD would improve stratification among HF patients. Methods results In a prospective observational study, 4 tertiary care hospitals Tokyo enrolled 2559 hospitalized who were successfully discharged...
BACKGROUND: The absence of practice standards in vasoactive agent usage for acute decompensated heart failure has resulted significant treatment variability across hospitals, potentially affecting patient outcomes. This study aimed to assess temporal trends and institutional differences vasodilator inotrope/vasopressor utilization among patients with failure, considering their clinical phenotypes. METHODS: Data were extracted from a government-funded multicenter registry covering the Tokyo...
Background: Evaluating the applicability of quality indicators (QIs) for heart failure (HF) care is crucial to addressing practice variability and improving outcomes by promptly translating guideline recommendations into QIs.
Increased angiogenesis, chronic inflammation, and extracellular matrix degradation are the major pathological features of abdominal aortic aneurysm (AAA). We sought to elucidate role vascular endothelial growth factor (VEGF)-A, a potent angiogenic proinflammatory factor, in development AAA. Human AAA samples showed increased VEGF-A expression, neovascularization, macrophage infiltration compared with normal walls. was induced mice by periaortic application CaCl2. were treated soluble...
In the early phase after transmural myocardial infarction (MI), infarcted myocardium undergoes replacement by scar tissue, which is essential for preserving structural integrity of tissue. Transforming growth factor (TGF)-beta1, known as a fibrotic cytokine, plays pivotal role in reparative fibrosis MI. It reported that granulocyte colony-stimulating (G-CSF) can accelerate wound healing. The aim our study was to investigate effect G-CSF on ventricular expansion MI.MI induced ligation left...
Abstract Aims Multimorbidity is common among heart failure (HF) patients and may attenuate guideline‐directed medical therapy (GDMT). Multimorbid are under‐represented in clinical trials; therefore, the effect of multimorbidity clustering on prognosis HF remains unknown. We evaluated prevalence clusters consecutively registered hospitalized assessed whether GDMT attenuated outcomes. Methods results examined 1924 with reduced left ventricular ejection fraction (<50%) a multicentre registry...
Background The burden of noncardiovascular conditions is becoming increasingly prevalent in patients with heart failure (HF). We aimed to identify novel phenogroups incorporating facilitate understanding and risk stratification elderly HF. Methods Results Data from a total 1881 (61.2%) aged ≥65 years were extracted prospective multicenter registry hospitalized for acute HF (N=3072). constructed subgroups preserved ejection fraction (HFpEF; N=826, 43.9%) those non-HFpEF (N=1055, 56.1%)....
The natural course of heart failure (HF) is typically associated with repeated hospitalizations, and subsequently, patient prognosis deteriorates. However, the precise relationship between admissions for HF long-term remains unknown.
Background Although 30-day readmission is thought to be an important quality indicator in patients with hospitalized heart failure, its prognostic impact and comparison of who were readmitted beyond 30 days has not been investigated. We assessed early (0-30 days) versus midrange (31-90 terms incidence distribution, elucidated whether the timing could have a different significance. Methods Results examined failure registered WET-HF (West Tokyo Heart Failure) registry. The primary outcomes...
Introduction Exercise pulmonary hypertension is common in patients with chronic thromboembolic (CTEPH) who experience shortness of breath during exercise and reduced capacity despite normalised arterial pressure (PAP) at rest; however, the relationship between remains unclear. Here we aimed to determine whether related ventilatory efficiency CTEPH resting haemodynamics after balloon angioplasty (BPA). Patients methods In total, 249 treated BPA (mean± sd age 63±14 years; male:female 62:187)...
Background: Ischemic stroke (IS) is a serious complication in heart failure, particularly following hospitalization for acute decompensated failure (ADHF). However, its actual incidence during the and stable treatment phases remains unclear. Moreover, association between IS hemoglobin levels, which fluctuate these phases, has not been comprehensively investigated. Methods: Patient-level data from 2018 to 2024 were extracted prospective multicenter cohort study that consecutively enrolled...
Depression and anxiety screening has not been adequately examined in patients with pulmonary hypertension (PH). We assessed depression prevalence their determinants arterial (PAH) chronic thromboembolic PH (CTEPH). This cross-sectional study included 234 (age 57 [42-68] years; 75% female; PAH/CTEPH/other: 103/126/5). Overall, 24% 26% of had (Hospital Anxiety Scale [HADS]-depression score ≥8) (HADS-anxiety respectively. was 18% 19% PAH 27% 30% CTEPH, Among PAH, significantly associated higher...