A5103031504- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Gout, Hyperuricemia, Uric Acid
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Pulmonary Hypertension Research and Treatments
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac Health and Mental Health
- Cardiac pacing and defibrillation studies
- Dialysis and Renal Disease Management
- Aortic aneurysm repair treatments
- Cardiomyopathy and Myosin Studies
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Chronic Kidney Disease and Diabetes
Yamagata University
1989-2025
The University of Tokyo
2009-2024
Yamagata University Hospital
2019-2024
Tokyo Gakugei University
2023-2024
German Center for Diabetes Research
2023
University Medical Center of the Johannes Gutenberg University Mainz
2023
German Cancer Research Center
2023
Helmholtz Zentrum München
2023
Center for Environmental Health
2023
University Medical Center Hamburg-Eppendorf
2023
Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies.
SA-I, SA-II *The morphofunctional phenotype description (M) may contain more information using standard abbreviations, such as AVB, atrioventricular block; WPW, Wolff-Parkinson-White syndrome; LQT, prolongation of the QT interval; AF, atrial fibrillation; ↓R, low electrocardiogram voltages; ↓PR, short PR interval.† Organ (O) involvement in addition to H subscript (for heart) should be expanded for M
Fulminant myocarditis presentation (FMP) is a rare and severe of myocarditis. The natural history FMP its clinical features associated with poor outcomes are incompletely understood because there lack generalizable evidence.This multicenter retrospective cohort study included patients hospitalized histologically proven who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 March 2017. Clinical the prognostic predictors...
Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease and increased with elderly population. However, effective drug therapy has not been established yet. This study aimed to investigate role of microRNAs (miRs) in development CAVS.We measured expression 10 miRs, which were reportedly involved calcification by using human tissue from patients who underwent replacement CAVS or regurgitation (AR) porcine interstitial cells (AVICs) after treatment osteogenic induction...
Hypertension is a major public health problem among the aging population worldwide. It causes cardiac remodeling, including hypertrophy and interstitial fibrosis, which leads to development of hypertensive heart disease (HHD). Although microRNA-21 (miR-21) associated with fibrogenesis in multiple organs, its contribution remodeling hypertension poorly understood. Circulating miR-21 level was higher patients HHD than that control subjects. also positively correlated serum myocardial fibrotic...
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) continues to be an increasingly common health problem associated a high mortality rate. Elevated levels of Growth differentiation factor‐15 (GDF15) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) are reportedly poor clinical outcomes in broad range cardiovascular diseases. The aim the present study was examine effect combined assessment these markers on patients HFpEF. Methods This is prospective observational...
A 77-year-old man presented for computed tomography (CT) with iodinated contrast follow-up of gastric cancer. After injection, the patient experienced cardiac arrest. post-return spontaneous circulation electrocardiogram showed ST segment elevation in inferior leads and V1-3. Since type I Kounis syndrome (KS) was suspected, corticosteroids antihistamines were administered intravenously. Subsequently, coronary angiography (CAG) revealed spasms, selective intracoronary injection nitrates...
Background: Positive and negative psychological factors are associated with mortality cardiovascular disease. This study prospectively investigated associations of daily frequency laughter disease in a community-based population.
The prognosis of peripheral artery disease (PAD) and comorbid sarcopenia is poor. Some reports indicate that the computed tomography (CT) value skeletal muscle, which reflects intramuscular fat deposition as well muscle mass, considered a marker sarcopenia. However, it remains unclear if area CT are associated with poor outcomes in patients PAD. Methods Results: Psoas were measured by manual trace at level third lumbar vertebral body 327 consecutive PAD undergoing endovascular therapy (EVT)....
High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased damage response (DDR) were observed in human failing hearts. DDR as well cardiac remodeling suppressed cardiac-specific overexpression transgenic mice after angiotensin II stimulation compared wild-type mice. In vitro, inhibition of phosphorylation extracellular signal-related kinase 1/2 factor kappa B, which was rescued by inhibitor...
Despite advances in medicine, aortic diseases (ADs) such as dissection and aneurysm rupture remain fatal with extremely high mortality rates. Owing to the relatively low prevalence of AD, risk AD-related death has not yet been elucidated. The aim present study was examine whether hyperuricemia is a factor for general population. We used nationwide database 474,725 subjects (age 40-75 years) who participated annual "Specific Health Check Guidance Japan" between 2008 2013. There were 115...
Abstract Aims Despite advances in heart failure (HF) treatment, HF with preserved ejection fraction (HFpEF) remains a health problem high mortality rate. HFpEF is composed of diverse phenogroups, which patients concomitant renal impairment have worse outcomes. Renal tubular damage (RTD) associated the development and chronic kidney disease (CKD). However, impact RTD on progression CKD unclear. The aim present study was to examine whether could predict HF‐related events CKD. Methods results...
Endothelial dysfunction and autonomic nervous system imbalance are both risk markers of atherosclerotic vascular damage. The relationship between these 2 factors, however, has not been clarified concisely.Flow-mediated dilation (FMD) was measured in 47 patients with ischemic heart disease (IHD; mean age, 68.1±7.1 years) using an ultrasound semi-automatic measuring (UNEXEF18G), activity evaluated by simultaneous measurements rate variability. FMD significantly correlated standard deviation...
We conducted a randomized, controlled trial to determine whether supplementation with oral branched-chain amino acids (BCAAs) improves serum albumin and clinical outcomes in heart failure (HF) patients hypoalbuminemia.We randomly assigned 18 in-hospital HF < 3.5 g/dL receive BCAA granules (LIVACT®) for 28 days during their hospital stay or until discharge (BCAA group; N = 9) no (controls; 9), addition recommended therapy. The primary endpoints were changes from baseline cardiothoracic ratio...