A5100705669- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Gout, Hyperuricemia, Uric Acid
- Nutrition and Health in Aging
- Cardiac pacing and defibrillation studies
- Chronic Kidney Disease and Diabetes
- Aortic Disease and Treatment Approaches
- Asthma and respiratory diseases
- Social Robot Interaction and HRI
- Metabolism and Genetic Disorders
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
Yamagata University
2016-2025
Osaka University
1981-2024
Yamagata University Hospital
2008-2022
Sakakibara Hospital
2020-2021
Fu Wai Hospital
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
University of Pecs
2017
Okayama Prefectural University
2002-2017
SAGE Publishing (United States)
2017
Creative Research Enterprises (United States)
2017
BackgroundThere is a residual risk of coronary heart disease (CHD) despite intensive statin therapy for secondary prevention. The aim this study was to investigate whether plaque regression and stabilization are reinforced by the addition eicosapentaenoic acid (EPA) high-dose pitavastatin (PTV).MethodsWe enrolled 193 CHD patients who underwent percutaneous intervention (PCI) in six hospitals. Patients were randomly allocated PTV group (PTV 4 mg/day, n = 96) or PTV/EPA mg/day EPA 1800 97),...
Background . Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular characterized by the superior increase aspartate aminotransferase (AST) to alanine (ALT). However, association AST/ALT ratio with brain natriuretic peptide (BNP) levels and mortality remains unclear general population. Methods Results This longitudinal cohort study included 3,494 Japanese who participated a community-based check-up, 10-year...
SA-I, SA-II *The morphofunctional phenotype description (M) may contain more information using standard abbreviations, such as AVB, atrioventricular block; WPW, Wolff-Parkinson-White syndrome; LQT, prolongation of the QT interval; AF, atrial fibrillation; ↓R, low electrocardiogram voltages; ↓PR, short PR interval.† Organ (O) involvement in addition to H subscript (for heart) should be expanded for M
Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine incident coronary artery disease. However, it remains unclear whether serum omentin-1 levels cardiac prognosis in patients HF. We measured at admission 136 consecutive HF, 20 control subjects without signs significant prospectively followed HF endpoints death or re-hospitalization for worsening Serum were markedly...
High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. HMGB1 binds to DNA, facilitating numerous including maintenance of genome stability, transcription, repair. However, little known about the effects cardiac hypertrophy heart failure. The aim this study was examine whether plays a role in development induced by pressure overload. Analysis human biopsy samples immunohistochemistry showed...
Background Resistin is derived from fat tissue in rodents, and serum levels are elevated animal models of obesity insulin resistance. Recent studies have reported that resistin correlated with markers inflammation oxidative stress predictive coronary atherosclerosis humans. However, clinical significance has not been examined heart failure. Therefore, the purpose this study was to examine whether: (1) severity failure; (2) can predict outcomes patients Methods Results Serum 126 hospitalized...
Background: Chronic pulmonary disorders, such as chronic obstructive disease (COPD) and fibrosing lung diseases, atrial fibrillation (AF), are prevalent in elderly people.The impact of cardiac co-morbidities the elderly, where function is impaired, cannot be ignored they influence mortality.The relationship between prevalence AF unclear.The aim this study was to evaluate participants a health check.Methods: Subjects aged 40 or older (n = 2,917) who participated community-based annual check...
The response-to-tissue-injury theory is currently the favorite paradigm to investigate valve pathology. To best of our knowledge, there are no in vivo injury models. There few calcific aortic stenosis (AVS) models that develop hemodynamically significant stenosis. Here, we investigated effect direct mechanical on valves and developed a novel mouse model AVS.Aortic was created by inserting moving spring guidewire under echocardiographic guidance into left ventricle male C57/BL6 mice via right...
Background: Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in production uric acid (UA).Patients with chronic obstructive pulmonary disease (COPD) have been reported to high serum levels UA (sUA), compared control subjects.However, relationship between sUA and spirometric measures has not investigated detail a general population.Methods: Subjects aged 40 years or older (n = 2,917), who had participated community-based annual health check Takahata, Japan, 2004...
Peripheral artery disease (PAD) is an athero-occlusive and a known risk factor for cardiovascular events. The controlling nutritional status (CONUT) score geriatric index (GNRI) are objective tools evaluating malnutrition reportedly associated with poor clinical outcomes in patients fatal diseases. However, the effect of on PAD remains unclear.Methods Results:We enrolled 357 who underwent endovascular therapy. Malnutrition was diagnosed by CONUT GNRI as previous reports. During median...
Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease and increased with elderly population. However, effective drug therapy has not been established yet. This study aimed to investigate role of microRNAs (miRs) in development CAVS.We measured expression 10 miRs, which were reportedly involved calcification by using human tissue from patients who underwent replacement CAVS or regurgitation (AR) porcine interstitial cells (AVICs) after treatment osteogenic induction...