A5076375061- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac Health and Mental Health
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Nutrition and Health in Aging
- Cardiovascular Health and Disease Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
Juntendo University
2016-2025
Juntendo University Hospital
2015-2025
Cardiovascular Research Foundation
2023
Boston Scientific (United States)
2023
Japan Agency for Medical Research and Development
2022
Foundation of Cardiac Surgery Development
2022
Jichi Medical University
2021
Shibuya University Network
2017-2018
RELX Group (United States)
2018
London Borough of Camden
2018
Revisions 1. CQs and Systematic Review (SR)In the subsections on dyslipidemia in assessment of risk factors, absolute ASCVD, lipid management targets as well drug therapy diet improving lifestyle habits, we created performed an SR based MINDS method.For our SR, essentially chose literature published before end 2015. Calculation Absolute RiskFollowing 2012 version, has been using calculation described this set guidelines.The NIPPON DATA80, which was used to calculate result baseline surveys...
Recent clinical trials have demonstrated that aggressive lipid lowering by statins could prevent recurrent events after acute coronary syndrome (ACS). We hypothesized this efficacy was caused a significant reduction in plaque volume LDL cholesterol (LCL-C) lowering. The present study investigated the effect of early statin treatment on nonculprit lesion serial volumetric intravascular ultrasound patients with ACS.Seventy ACS were enrolled. All underwent emergency angiography and percutaneous...
Among the various atherosclerotic cardiovascular diseases (CVDs), these guidelines primarily deal with cerebrovascular disease, peripheral arterial disease (PAD) and coronary artery (CAD), which occur in association atherosclerosis is closely related to dyslipidemia.
Abstract Background Oxidized low-density lipoprotein (oxLDL) uptake by macrophages plays an important role in foam cell formation. It has been suggested the presence of heterogeneous subsets macrophage, such as M1 and M2, human atherosclerotic lesions. To evaluate which types contribute to atherogenesis, we performed cDNA microarray analysis determine oxLDL-induced transcriptional alterations each subset macrophages. Results Human monocyte-derived were polarized toward or M2 subset, followed...
Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence more statins has been established an Asian population. In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese stable coronary artery who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were...
BACKGROUND: Low plasma levels of eicosapentaenoic acid (EPA) are associated with cardiovascular events. This trial aimed to assess the clinical benefits icosapent ethyl in patients coronary artery disease, a low EPA/arachidonic (AA) ratio, and statin treatment. METHODS: In this prospective, multicenter, randomized, open-label, blinded end-point study, stable disease EPA/AA ratio (<0.4) were randomized EPA (1800 administered daily) or control group. The primary end point was composite...
ABSTRACT After the first attachment of virus to cell surface through a primary receptor, efficient entry requires presence coreceptor. For adeno-associated type 2 (AAV2) infection, heparan sulfate proteoglycan is supposed as and αvβ5 integrin FGFR1 are reported act coreceptors. In this study, we were able demonstrate that hepatocyte growth factor c-Met, also coreceptor for AAV2 infection. AAV2-mediated transgene analyses revealed c-Met expression significantly up-regulated without increasing...
The granulocyte colony-stimulating factor (G-CSF) promotes angiogenesis. However, the exact mechanism is not known. We demonstrate that vascular endothelial growth (VEGF) was released by Gr-1+CD11b- neutrophils but Gr-1-CD11b+ monocytes prestimulated with G-CSF in vitro and vivo. Similarly, vivo, concomitant an increase neutrophil numbers circulation, augmented plasma VEGF level Local administration into ischemic tissue increased capillary density provided a functional vasculature...
Plasma pentraxin 3 (PTX3) levels are increased in patients with acute myocardial infarction, yet its involvement unstable angina pectoris (UAP) remains unclear. To critically evaluate the role of PTX3 UAP, a sensitive and precise measurement concentration is needed.We established high plasma ELISA assay system for detection using monoclonal antibodies. The lower limit our was 0.1 ng/mL, sensitivity far greater than current commercially available kit. samples were obtained from 162...
Epidemiological studies have shown that the incidence of coronary artery disease increases as LDL- C, TC1-9), and TG10, 11) levels rise HDL-C level lowers5, 8, 12) both in Japan Western countries (Fig.1). At present, prevalence is much lower than countries13-16). However, recent LDL-C TC Japanese associated with so-called Westernization diet implies future disease. In this guideline, therefore, criteria for diagnosis dyslipidemia were defined Table 1, a greater emphasis on prevention...
Background: It has been suggested that intensive lipid-lowering therapy using statins significantly decreases atheromatous plaque volume. The effect of rosuvastatin on volume in patients with stable coronary artery disease (CAD), including those receiving prior therapy, was examined the present study. Methods and Results: A 76-week open-label trial performed at 37 centers Japan. Eligible began treatment 2.5 mg/day, which could be increased 4-week intervals to ≤20 mg/day. total 214 underwent...
Epidemiological studies have shown that the incidence of coronary artery disease increases as LDL- C, TC1-9), and TG10, 11) levels rise HDL-C level lowers5, 8, 12) both in Japan Western countries (Fig.1). At present, prevalence is much lower than countries13-16). However, recent LDL-C TC Japanese associated with so-called Westernization diet implies future disease. In this guideline, therefore, criteria for diagnosis dyslipidemia were defined Table 1, a greater emphasis on prevention...
Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status and rate of subsequent atherothrombotic after acute coronary syndrome (ACS) are limited in patients. The objective this study was to clarify long-term outcomes ACS Methods Results: Prevention AtherothrombotiC Incidents Following Ischemic Coronary attack (PACIFIC) registry is a multicenter, prospective observational Consecutive aged ≥20...