BACKGROUND: Low plasma levels of eicosapentaenoic acid (EPA) are associated with cardiovascular events. This trial aimed to assess the clinical benefits icosapent ethyl in patients coronary artery disease, a low EPA/arachidonic (AA) ratio, and statin treatment. METHODS: In this prospective, multicenter, randomized, open-label, blinded end-point study, stable disease EPA/AA ratio (<0.4) were randomized EPA (1800 administered daily) or control group. The primary end point was composite...

To evaluate the association between pre-diagnostic circulating vitamin D concentration and subsequent risk of overall site specific cancer in a large cohort study.Nested case-cohort study within Japan Public Health Center-based Prospective Study cohort.Nine public health centre areas across Japan.3301 incident cases 4044 randomly selected subcohort participants.Plasma 25-hydroxyvitamin measured by enzyme immunoassay. Participants were divided into quarters based on sex season distribution...

Abstract Background Pregnancy and lactation-associated osteoporosis (PLO), as well premenopausal osteoporosis, might be a predictor of future fracture. This study aimed to describe the clinical features PLO subtype evaluate medical interventions for it. Methods From an administrative claims database including 4,224,246 people in Japan, we classified women whom date childbirth had been defined who suffered low-trauma fracture between ages 18–47 years group. A site which odds ratio fractures...

ABSTRACT Objectives The diagnosis of early‐onset Alzheimer's disease (EOAD) can cause emotional stress not only to the patients themselves but also their spouses. This study aimed evaluate risk psychiatric disorders in spouses EOAD patients, using psychotropic drug initiation as a surrogate indicator. Methods A cohort was conducted Japanese claims database, with (exposed spouses) matched non‐EOAD individuals (reference up 1:10 ratio. Primary outcome mood disorder drugs, and secondary...

Chronic pain is a common cause of reduced quality life. Recent studies suggest that chronic patients have different brain neurometabolic status to healthy people. Proton magnetic resonance spectroscopy (1H-MRS) can determine the concentrations metabolites in specific region without being invasive.We recruited 56 and 60 controls compare metabolic characteristics. The glutamic acid (Glu), myo-inositol (Ins), N-acetylaspartate (NAA), Glu + glutamine (Glx), creatine phosphocreatine (total [tCr])...

Purpose This study aimed to assess the trends in antipsychotic prescriptions for outpatients Japan, where a community-based approach mental healthcare is emphasized. Methods descriptive epidemiological used claims data from 1038 community pharmacies across Japan. Outpatients who were ≥18 years old and receiving their initial prescription during 2006–2012 evaluated. The annual reported monotherapies, polypharmacy, doses, concurrent of psychotropic medications. Results 152 592 included 101 133...

In chronic low back pain (CLBP) patients, study of altered brain metabolites in the anterior cingulate cortex (ACC) using magnetic resonance spectroscopy (MRS) could reveal detailed pathology CLBP and depression. The aim was to detect central difference between controls by means measuring ACC, analyze correlations depression ACC.MRS performed (n=60) control participants (n=56) evaluate effects on ACC questionnaire scores a cross-sectional study.Adjusting for age sex, negative effect...

Although numerous measures for stroke exist, remains one of the leading causes death in Japan. In this study, we aimed to determine long-term survival rate after first-ever using data from a large-scale population-based registry study Japan.Part Shiga Stroke and Heart Attack Registry, Registry is an ongoing stroke, which covers approximately 1.4 million residents Prefecture A total 1,880 patients with non-fatal (among 29-day survivors onset) registered 2011 were followed up until December...

Abstract We previously developed and validated a risk prediction model for colorectal cancer in Japanese men using modifiable factors. To further improve prediction, we evaluated the degree of improvement obtained by adding genetic score (GRS) genome-wide association study (GWAS)-identified variants to our model. examined between 36 identified GWAS weighted Cox proportional hazards nested case–control within Japan Public Health Center-based Prospective Study. GRS was constructed six...

Objective . To assess dose, characteristics, and coprescribed analgesics in patients newly prescribed pregabalin for neuropathic pain fibromyalgia Japan. Methods Based on the medical prescription information present Medical Data Vision database, we analyzed initial maximum daily doses, period, analgesics, pain-related disorders of between 01 July 2010 31 December 2013. Results A total 45,331 (mean age 66.8 years, 48.7% men) were during this period. The mean doses 97.3 mg 127.8 mg,...

Studies using data from Western countries have raised concerns that treating pregnant women with antidepressants may increase the risk of autism spectrum disorders (ASDs) in their offspring. However, to date, studies are inconclusive. We therefore examined association between antidepressant use and ASD claims collected Japan.This retrospective cohort study was based on mothers children January 2005 July 2014, obtained Japan Medical Data Center. The information linked family identification...

Certain studies previously pointed out that treating pregnant women with antidepressants may increase risks of congenital anomalies in their children. However, to date, the study results are not conclusive. Furthermore, most have been performed using data from Western countries; therefore, we examined this association Japanese data. This retrospective cohort was based on claims mothers and children January 2005 July 2014, obtained JMDC Inc. Information antidepressant prescriptions extracted...

Aim: To investigate the incidence and in-hospital mortality of acute myocardial infarction (AMI) by conforming to Universal Definition Myocardial Infarction (UDMI) in a population-based registry.

Key Points This large, contemporary study reports the management of anemia in a real-world cohort patients with nondialysis-dependent CKD from multifaceted aspects. highlights suboptimal and heterogeneous treatment clinical practice. The findings also underscore importance maintaining stable hemoglobin concentration within target range to reduce risk mortality morbidity. Background Anemia has attracted attention introduction novel therapeutic agents; however, few studies have provided...

This study evaluates the cost-effectiveness of implants (Implant), insurance fixed dental prosthesis (IFDP) and private (PFDP) for a single intermediate missing tooth in molar region to calculate Incremental Cost Effectiveness Ratio (ICER). The Markov model analysis Implant, IFDP PFDP was carried over maximum 30 years. starting age prosthetic treatment decided be 50 General Oral Health Assessment Index (GOHAI) used indicator effectiveness as an oral health QOL value. GOHAI value collected...

Honeycombing on high-resolution computed tomography (HRCT) images is a key finding in idiopathic pulmonary fibrosis (IPF). In IPF, honeycombing area determined by quantitative CT analysis correlated with function test findings. We hypothesized that CT-derived (HA) might predict mortality patients IPF.Chest HRCT of 52 IPF definite usual interstitial pneumonia (UIP) pattern were retrospectively evaluated. Mortality data up to July 31, 2016, recorded. Using computer-aided system, HA and...

<b><i>Introduction:</i></b> The purpose of this study was to investigate seasonal variation in stroke incidence using data from a large-scale registry general population current Japan. <b><i>Methods:</i></b> Shiga Stroke Registry (SSR) is an ongoing population-based that occurred the Prefecture central Honshu, A total 6,688 cases first-ever stroke, with onset dates ranging 1 January 2011 31 December 2013 were included study. Incidence rates...

Background: While being obese in mid-life is associated with an increased risk of dementia and cognitive decline late-life, late-life shown to be a lower these outcomes some studies. This phenomenon known as the “obesity paradox”, but underlying reasons potential sex difference have not been well understood. Objective: To investigate association between cognition waist circumference (WC), alternative measure body fat which can measured easier than mass index (BMI), among older adults each...

Acute aortic dissection (AAD) is a life-threatening cardiovascular disease, with reported incidence rate ranging from 2.5 to 7.2 per 100,000 person-years in several population-based registries Western countries, but epidemiological data are lacking Japan.

Abstract Background Pediatric allergic rhinitis (AR), including cedar pollinosis (CP), is increasing in Japan. We investigated the effects of sublingual immunotherapy (SLIT), which has limited studies its effectiveness real‐world settings, on children with CP. Methods This retrospective cohort study used a claim database 2018–2021. Children aged ≤15 years CP records 2019 were eligible and followed up through 2021. included 2962 undergoing SLIT 547 who not. The medication score was to...

We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study 406 They were categorized into three groups based on findings monitoring. A total 377 met inclusion criteria classified as low ( n = 172), moderate 136) high 69). In total, 86 53 receive further evaluation. 29 25 diagnosed 12 required additional treatment, including coronary intervention. Over 1.8...