A5101739857- Aldose Reductase and Taurine
- Prenatal Substance Exposure Effects
- Barrier Structure and Function Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Biochemical effects in animals
- Cannabis and Cannabinoid Research
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Connexins and lens biology
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cardiac Ischemia and Reperfusion
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Antioxidant Activity and Oxidative Stress
- Alcohol Consumption and Health Effects
- Bee Products Chemical Analysis
- Alkaline Phosphatase Research Studies
- Cancer-related molecular mechanisms research
- Magnesium in Health and Disease
- Caveolin-1 and cellular processes
- Diet, Metabolism, and Disease
- Paraoxonase enzyme and polymorphisms
Gifu Pharmaceutical University
2015-2024
Kraft Heinz (United States)
2019
GTx (United States)
2011-2018
Gifu University
2013-2015
Laboratoire de Biochimie
2015
Fukuoka University
2014
Monash University
2014
Hokuriku University
2014
Nagoya University
2013
National Center for Geriatrics and Gerontology
2013
The mitochondria-targeted drugs mitoquinone (Mito-Q) and mitovitamin E (MitoVit-E) are a new class of antioxidants containing the triphenylphosphonium cation moiety that facilitates drug accumulation in mitochondria. In this study, Mito-Q (ubiquinone attached to cation) MitoVit-E (vitamin were used. aim study was test hypothesis inhibit peroxide-induced oxidative stress apoptosis bovine aortic endothelial cells (BAEC) through enhanced scavenging mitochondrial reactive oxygen species, thereby...
Claudin-2 is highly expressed in human lung adenocarcinoma tissues and cells. Knockdown of claudin-2 decreases cell proliferation migration. may be a novel target for adenocarcinoma. However, there are no physiologically active substances foods which decrease expression. We here found that quercetin, flavonoid present fruits vegetables, time- concentration-dependently expression A549 In the study, we examined what regulatory mechanism involved by quercetin. was decreased LY-294002,...
The human aldo-keto reductase AKR1B10, originally identified as an aldose reductase-like protein and small intestine reductase, is a cytosolic NADPH-dependent that metabolizes variety of endogenous compounds, such aromatic aliphatic aldehydes dicarbonyl some drug ketones. enzyme highly expressed in solid tumors several tissues including lung liver, has received considerable interest relevant biomarker for the development those tumors. In addition, AKR1B10 been recently reported to be...
Claudin-2 is highly expressed in human lung adenocarcinoma tissues and may be a novel target for cancer chemotherapy because knockdown of claudin-2 decreases cell proliferation. We found that flavonoids including kaempferol, chrysin, luteolin concentration-dependently decrease expression A549 cells. up-regulated by mitogen-activated protein kinase (MEK)/ extracellular signal-regulated (ERK)/c-Fos phosphoinositide 3-kinase (PI3K)/Akt/nuclear factor-κB (NF-κB) pathways, but these activities...
Several previous investigators have reported that long-term administration of certain macrolides is efficacious in patients with persistent pulmonary Pseudomonas aeruginosa infections, even though the clinically achievable concentrations these medications are far below their MICs. In present study, we examined how sub-MICs macrolide antibiotics affect viability and protein synthesis several strains P. aeruginosa. We report 48 h, but not 12 or 24 growth on agar containing a concentration...
Sphingolipid ceramide (N-acetylsphingosine), a bioactive second messenger lipid, was shown to activate reactive oxygen species (ROS), mitochondrial oxidative damage, and apoptosis in neuronal vascular cells. The proapoptotic effects of tumor necrosis factor-alpha, hypoxia, chemotherapeutic drugs were attributed increased formation. Here we investigated the protective role nitric oxide (.NO) during hydrogen peroxide (H(2)O(2))-mediated transferrin receptor (TfR)-dependent iron signaling...
A human member of the aldo-keto reductase (AKR) superfamily, AKR1B10, was recently suggested as a therapeutic target in treatment several types cancer. Due to its high sequence identity with aldose (AKR1B1), selective inhibition AKR1B10 compared AKR1B1 is required for development anticancer agents. In this study, we have examined by seven pentacyclic triterpenes (1–7) that show potential properties. Among them, oleanolic acid (1) found be most potent competitive inhibitor (inhibition...