A5056664497- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Microbial Metabolic Engineering and Bioproduction
- Gastrointestinal Tumor Research and Treatment
- RNA and protein synthesis mechanisms
- Tracheal and airway disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adipose Tissue and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Cancer Treatment Studies
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Complementary and Alternative Medicine Studies
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Soybean genetics and cultivation
- Voice and Speech Disorders
- Tissue Engineering and Regenerative Medicine
- Salivary Gland Tumors Diagnosis and Treatment
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
The University of Tokyo
2011-2024
Tokyo University of Science
2005-2024
Central Region Agricultural Research Center
2018-2024
Tokyo Medical and Dental University
2023-2024
Yokohama City University Medical Center
2024
Yokohama City University
2016-2024
National Agriculture and Food Research Organization
2000-2024
Gifu University
2009-2023
Fukuyama City Hospital
2016-2022
Kyoto University
2009-2021
We examined changes in brain waves and blood levels of serum Cortisol during yoga exercise 7 instructors found that alpha increased decreased. These two measures were negatively correlated ( r = -.83). Comparison with a control group nonpractitioners is desirable.
A good prognosis can be expected for most, but not all, cases of thyroid papillary cancer. Numerous molecular studies have demonstrated beneficial treatment and prognostic factors in various markers. Whereas most previous reports focused on genomics proteomics, few lipidomics. With the advent mass spectrometry (MS), it has become possible to identify many types molecules, this analytical tool critical field omics. Recently, imaging (IMS) was developed. After a simple pretreatment process,...
Radiotherapy is one of the most effective treatments for head and neck cancer. However, development dry mouth syndrome an unavoidable side effect because, in addition to tumor, normal salivary glands are included irradiation field. Previously, we investigated protective efficacy basic fibroblast growth factor (bFGF) radiation-damaged glands. In this study, adipose-derived stromal cell (ADSC) transplantation regeneration radiation damaged glands.Prospective animal experiment with...
Insulin triggers an extensive signaling cascade to coordinate adipocyte glucose metabolism. It is considered that the major role of insulin provide anabolic substrates by activating GLUT4-dependent uptake. However, stimulates phosphorylation many metabolic proteins. To examine implications this on metabolism, we performed dynamic tracer metabolomics in cultured adipocytes treated with insulin. Temporal analysis metabolite concentrations and labeling revealed rapid distinct changes favoring...
Abstract Entire reconstitution of tRNAs for active protein production in a cell-free system brings flexibility into the genetic code engineering. It can also contribute to field synthetic biology, which aims construct self-replicable artificial cells. Herein, we developed equipped only with vitro transcribed tRNA (iVTtRNA) based on reconstituted synthesis (PURE) system. The system, consisting 21 iVTtRNAs without nucleotide modifications, is able synthesize proteins according redesigned code....
3-hydroxypropionic acid (3HP) is an important chemical precursor for the production of bioplastics. Microbial 3HP from glycerol has previously been developed through optimization culture conditions and biosynthesis pathway. In this study, a novel strategy improving in Escherichia coli was investigated by modification central metabolism based on genome-scale metabolic model experimental validation.Metabolic simulation identified double knockout tpiA zwf as candidate production. A...
Starvation induces complex metabolic adaptations in skeletal muscle, a key tissue for maintaining energy homeostasis; however, these are largely impaired obesity. How obesity alters global to starvation muscle remains unclear. Here, we analyzed the on trans-omics scale during from wild-type (WT) and leptin-deficient obese ( ob / ) mice. We measured multi-omics data constructed networks WT found that "responsiveness" mice, characterized by increases or decreases regulator metabolites,...
Metabolism, the biochemical reaction network within cells, is crucial for life, health, and disease. Recent advances in multi-omics technologies, enabling simultaneous measurement of transcripts, proteins, metabolites, provide unprecedented opportunities to comprehensively analyze metabolic regulation. However, effectively integrating these diverse data types decipher complex interplay between enzymes metabolites remains a significant challenge due extensive requirements kinetic modeling...
We found that both tetramethylammonium chloride (TMA-Cl) and tetra-ethylammonium (TEA-Cl), which are used as monovalent cations for northern hybridization, drastically destabilized the tertiary structures of tRNAs enhanced formation tRNA•oligoDNA hybrids. These effects great advantage hybridization-based method purification specific from unfractionated tRNA mixtures through use an immobilized oligoDNA complementary to target tRNA. Replacement NaCl by TMA-Cl or TEA-Cl in hybridization buffer...
Transfer RNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes N2,N2-dimethylguanine formation at position 26 (m22G26) in tRNA. In the reaction, N2-guanine (m2G26) is generated as an intermediate. The trm1 genes are found only archaea and eukaryotes, although it has been reported that Aquifex aeolicus, a hyper-thermophilic eubacterium, putative gene. To confirm whether A. aeolicus Trm1 tRNA methyltransferase activity, we purified recombinant protein. vitro methyl transfer assay revealed...
Abstract Motivation: Although constraint-based flux analysis of knockout strains has facilitated the production desirable metabolites in microbes, current screening methods have placed a limitation on number knockouts that can be simultaneously analyzed. Results: Here, we propose novel method named FastPros. In this method, potential given reaction for specific metabolite is evaluated by shadow pricing constraint balance analysis, which generates score to obtain candidate sets. To evaluate...
The microscopic mechanism of low-temperature (80 K < T 160 K) hydrogen (H) ingress into the H2 (<2.66 × 10−3 Pa) exposed Pd(110) surface is explored by H depth profiling with 15N nuclear reaction analysis (NRA) and thermal desorption spectroscopy (TDS) isotope (H, D) labeled hydrogen. NRA TDS reveal two types absorbed states distinctly different distributions. Between 80 ∼145 a near-surface hydride phase evolving as α1 feature at forms, which initially extends only several...
Acellular extracellular matrix scaffold derived from porcine urinary bladder (UBM) is decellularized material that has shown success for constructive remodelling of various tissues and organs. The regenerative effects UBM were reported the tympanic membrane, oesophagus, trachea, larynx, pleura pericardium in animal studies, with promising results. aim this study was to investigate on hemilarynx, using a canine model. A left partial hemilaryngectomy performed surgical defects reconstructed by...
Systemic metabolic homeostasis is regulated by inter-organ cycles involving multiple organs. Obesity impairs cycles, resulting in diseases. The systemic landscape of dysregulated obesity has yet to be explored. Here, we measured the transcriptome, proteome, and metabolome liver skeletal muscle blood fasted wild-type leptin-deficient obese (ob/ob) mice, identifying components with differential abundance regulation ob/ob mice. By constructing evaluating trans-omic network controlling...
Abstract Although several hypotheses have been proposed explaining the mechanisms of immune‐privileged status malignant tumors, exact pathway is yet to be explored. Tumor stroma plays a vital role in prognosis cancer patients; however, immunomodulatory impact gastric has not reported. We evaluated amount stromal collagen and its on infiltration immune‐competent cells into tumor cell nest carcinoma. Tissue specimens from 84 advanced carcinoma patients who had undergone curative resection were...