A5008892299- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ruminant Nutrition and Digestive Physiology
- Speech and Audio Processing
- Advanced Data Compression Techniques
- Liver Disease Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial Metabolites in Food Biotechnology
- Phonocardiography and Auscultation Techniques
- Biofuel production and bioconversion
- Reproductive Physiology in Livestock
- Enzyme Production and Characterization
- Video Coding and Compression Technologies
- Carbon dioxide utilization in catalysis
- Music and Audio Processing
- Animal health and immunology
- Hearing, Cochlea, Tinnitus, Genetics
- T-cell and Retrovirus Studies
- Medical Imaging Techniques and Applications
- Blind Source Separation Techniques
- Gut microbiota and health
- Insect behavior and control techniques
- Cardiac Imaging and Diagnostics
The University of Tokyo
2010-2025
Hokkaido University
2017-2024
Kasetsart University
2023
Suzuki (Japan)
1991-2022
University of Yamanashi
2010-2021
Takeda (Japan)
2020-2021
Kuraray (United States)
2020
Nihonkai General Hospital
2013-2019
Kuraray (Japan)
2019
University of Alberta
2018
Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on binding to isolated adipocytes. Administration of ganoderan significant increases activities hepatic glucokinase, phosphofructokinase glucose-6-phosphate dehydrogenase, decreased glycogen synthetase did not affect hexokinase phosphorylase. reduced content liver had influence total cholesterol triglyceride levels liver.
The reliability and frequency specificity of the 80-Hz amplitude-modulation-following response (80-Hz AMFR) during sleep detected by phase coherence as a measure hearing threshold was evaluated in 169 affected ears 125 children with impairment. AMFR at carrier 1000 Hz monitored all auditory brainstem (ABR) elicited 1000-Hz tone pips 93 ears. Both responses were examined sleep, thresholds compared behavioral threshold, which determined standard pure-tone audiometry or play audiometry. In 24...
Starvation induces complex metabolic adaptations in skeletal muscle, a key tissue for maintaining energy homeostasis; however, these are largely impaired obesity. How obesity alters global to starvation muscle remains unclear. Here, we analyzed the on trans-omics scale during from wild-type (WT) and leptin-deficient obese ( ob / ) mice. We measured multi-omics data constructed networks WT found that "responsiveness" mice, characterized by increases or decreases regulator metabolites,...
Abstract An enzyme with strong single-stranded DNA (ssDNA) ligation activity would be advantageous for many molecular biology applications. However, currently available enzymes exhibit only limited activity. Here, we identified an ssDNA upon searching the databases proteins homologous to TS2126 RNA ligase, known highest yet A ligase from Thermus phage phiLo (GenBank: AYJ73970) or Tph (SDL) depicted higher than ligase. This study suggests that SDL could useful various applications including...
Vaccine immunogenicity is influenced by the vaccinee's genetic background. Here, we perform a genome-wide association study of vaccine-induced SARS-CoV-2-specific immunoglobulin G (IgG) antibody titers and T cell immune responses in 1,559 mRNA-1273 537 BNT162b2 vaccinees Japanese ancestry. are associated with heavy chain (IGH) major histocompatibility complex (MHC) locus, MHC. The lead variants at IGH contain population-specific missense variant (rs1043109-C; p.Leu192Val) constant gamma 1...
Although it has been reported that oxytocin stimulates lipolysis in adipocytes, changes the expression of receptor (OTR) mRNA adipogenesis are still unknown. The present study aimed to investigate OTR during adipocyte differentiation and fat accumulation adipocytes. was highly expressed adipocytes prepared from mouse adipose tissues compared stromal-vascular cells. increased 3T3-L1 levels were higher subcutaneous epididymal 14-week-old male mice 7-week-old mice. Levels at four different...
A new algorithm is proposed for predicting pixels inter frame coding without side information. There are many approaches in the past that exploited either spatial or temporal correlations generating prediction signals of an image a block-by-block basis. Our method this paper exploits both and at once to predict be encoded. The achieved by using template matching mechanism, with reference previously reconstructed groups same adjacent frames, fill target regions frame. This process conducted...
The combined and separate effects of exercise training bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength (3 d/week) received matched placebo; with or placebo served as nonexercising controls. Bone mineral, lean tissue, fat mass assessed by dual-energy X-ray absorptiometry before after 12 months intervention. After removal outlier...
Neurotensin (NT) has multiple functions, ranging from acting as a neurotransmitter to regulating intestinal movement. However, its function in reproductive physiology is unknown. Here, we confirmed the expression and localization of NT receptors (NTR1) mouse epididymal spermatozoa investigated effect on sperm function. Sperm protein tyrosine phosphorylation, one indices capacitation, was facilitated dose-dependently by administration. In addition, acrosome reaction promoted capacitated...
Global warming has resulted in the loss of anthocyanin accumulation berry skin. Sound stimulation can be used as a potential method for enhancing fruit color development since many plants recognize sound vibration an external stimulus and alter their physiological status response to it. (sine wave at 1000 Hz) enhanced grape cultured cells skins field-grown grapevines early stage ripening. The transcription UFGT ACO2, which encode key enzymes ethylene biosynthesis, respectively, was...
Abstract Background Carbohydrate-active enzymes (CAZymes) form the most widespread and structurally diverse set of involved in breakdown, biosynthesis, or modification lignocellulose that can be found living organisms. However, structural diversity CAZymes has rendered targeted discovery novel extremely challenging, as these proteins catalyze many different chemical reactions are sourced by a vast array microbes. Consequently, uncharacterized members CAZyme families interest have been...
Abstract Direct and regioselective carboxylation of fused aromatic compounds with carbon dioxide is achieved the aid a Lewis acid. Thus, treatment naphthalene, anthracene, phenanthrene (3.0 MPa) in benzene at 40 °C presence AlBr3 gave 1-naphthoic acid, 9-anthracenecarboxylic 9-phenanthrenecarboxylic acid as sole product 43, 20, 34% yields, respectively.
Of 15 patients with Takayasu's arteritis studied by 131I-macroaggregated albumin lung scanning, 12 showed perfusion abnormalities. The scan proved very useful in detecting the pulmonary artery disorders associated arteritis. pathogenesis of this disease and clinical usefulness study are discussed.
Abstract Some carriers of human T-cell leukaemia virus type 1 (HTLV-1), a retrovirus that primarily infects CD4+ T cells and causes lifelong infection, develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Current treatments for HAM/TSP are insufficient with problematic long-term side effects. This study evaluated the safety efficacy anti-CCR4 antibody mogamulizumab in patients over 4-year period. We conducted an open-label, extended (UMIN trial number: UMIN000019942)...
Abstract The Lewis acid-mediated carboxylation of aromatic compounds with CO2 is significantly promoted by the addition a large excess chlorotrimethylsilane (TMSCl) to give arylcarboxylic acids in good excellent yields.
The non-dialyzable portion of the water extract Oriental crude drug "karokon", roots Trichosanthes kirilowii, was found to reduce plasma glucose level in mice. Activity-guided fractionation this led isolation five glycans termed as trichosans A, B, C, D and E, showing hypoglycemic actions normal main glycan, trichosan also exhibited activity alloxan-induced hyperglycemic
Adipokines, adipocyte-derived protein, have important roles in various kinds of physiology including energy homeostasis. Chemerin, one adipokines, is highly expressed differentiated adipocytes and known to induce macrophage chemotaxis glucose intolerance. The objective the present study was investigate changes chemerin chemokine-like-receptor 1 (CMKLR1) gene expression levels during differentiation bovine adipocyte treated with tumor necrosis factor-α (TNF-α), adiponectin, leptin, (peptide...
ABSTRACT Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis the regulatory mechanism of its own receptor in mice cattle. The objective present study was to investigate physiological effect on endocrine changes metabolism sheep using biologically stable analog. analog intravenously administrated (100 or 500 µg/head) sheep, plasma insulin metabolites (glucose, nonesterified fatty acids (NEFA),...