Aoxing Liu
A5030801342- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Effects of Environmental Stressors on Livestock
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Sexual Differentiation and Disorders
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Respiratory viral infections research
- BRCA gene mutations in cancer
- Sleep and related disorders
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Machine Learning in Healthcare
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Viral-associated cancers and disorders
- Genomics and Rare Diseases
- Animal Behavior and Welfare Studies
- Colorectal Cancer Treatments and Studies
- Stress Responses and Cortisol
- Frailty in Older Adults
- Sleep and Wakefulness Research
Institute for Molecular Medicine Finland
2020-2025
University of Helsinki
2021-2025
Broad Institute
2023-2025
Massachusetts General Hospital
2024-2025
Shanghai Institute of Materia Medica
2025
Chinese Academy of Sciences
2025
Nanjing University of Chinese Medicine
2025
Finland University
2023-2024
Ningxia University
2024
University of California, Davis
2024
Abstract Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These survived the founding bottleneck rather than being distributed over large ultrarare variants. Although this effect is well established Mendelian genetics, its value common disease genetics less explored 1,2 . FinnGen aims to study genome and national health register data...
ABSTRACT Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles any gene is often concentrated on a small number low-frequency variants (0.1% ≤ minor allele frequency < 5%), which survived founding bottleneck, opposed to being distributed over much larger ultra--rare variants. While this advantage well-- established Mendelian genetics, its value common disease genetics has been less explored. FinnGen aims study genome and...
Novel immunisation methods against respiratory syncytial virus (RSV) are emerging, but knowledge of risk factors for severe RSV disease is insufficient optimal targeting interventions them. Our aims were to identify predictors hospital admission from registry-based data and develop validate a clinical prediction model guide immunoprophylaxis infants younger than 1 year.In this development validation study, we studied all born in Finland between June 1, 1997, May 31, 2020, Sweden 2006, along...
Studies show that sex plays a role in stress-related depression, with women experiencing higher vulnerability to its effect. Two major targets of antidepressants are brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate response element–binding protein (CREB). The aim this study was investigate the levels CREB, phosphorylation CREB (pCREB), BDNF brain regions male female rats after stress recovery. pCREB were examined CA1, CA2, CA3, paraventricular nucleus thalamus...
Genotype-by-environment (G × E) interactions could play an important role in cattle populations, and it should be considered breeding programmes to select the best sires for different environments. The objectives of this study were G E female fertility traits Danish Holstein dairy population using a reaction norm model (RNM), detect particular genomic regions contributing performance these interactions. In total 4534 bulls genotyped by Illumina BovineSNP50 BeadChip. An RNM with...
The availability of whole genome sequencing (WGS) data enables the discovery causative single nucleotide polymorphisms (SNPs) or SNPs in high linkage disequilibrium with SNPs. This study investigated effects integrating selected from imputed WGS into 54K chip on genomic prediction Danish Jersey. SNPs, mainly including peaks quantitative trait loci, structure variants, regulatory regions genes, and within genes strong predicted variant effect predictor, were previous analyses for dairy breeds...
Abstract The percentage of people without children over their lifetime is approximately 25% in men and 20% women. Individual diseases have been linked to childlessness, mostly women, yet we lack a comprehensive picture the effect early-life on childlessness. We examined all individuals born 1956–1968 (men) 1956–1973 (women) Finland ( n = 1,035,928) Sweden 1,509,092) completion reproductive lifespan 2018. Leveraging nationwide registers, associated sociodemographic information with 414 across...
ABSTRACT Sex chromosome trisomies (SCT) are the most common whole aneuploidy in humans. Yet, our understanding of prevalence and associated health outcomes is largely driven by observational studies clinically diagnosed cases, resulting a disproportionate focus on 47,XXY hypogonadism. We analyzed microarray intensity data sex chromosomes for 1.5 million individuals enrolled three large cohorts—Million Veteran Program, FinnGen, UK Biobank—to identify with 47,XXY, 47,XYY, 47,XXX. examined...
Vaccine immunogenicity is influenced by the vaccinee's genetic background. Here, we perform a genome-wide association study of vaccine-induced SARS-CoV-2-specific immunoglobulin G (IgG) antibody titers and T cell immune responses in 1,559 mRNA-1273 537 BNT162b2 vaccinees Japanese ancestry. are associated with heavy chain (IGH) major histocompatibility complex (MHC) locus, MHC. The lead variants at IGH contain population-specific missense variant (rs1043109-C; p.Leu192Val) constant gamma 1...
Due to the complexity of longevity trait in dairy cattle, two groups definitions are widely used measure longevity, either covering full lifespan or representing only a part it achieve an early selection. Usually, one group definition is breeding program for population, and genetic studies on comparisons scarce. Based data eight traits well both definitions, current study investigated parameters architectures Holsteins. Heritabilities correlations were estimated using single-trait...
Heat stress is a major cause of welfare issues and economic losses to the worldwide dairy cattle industry. Genetic selection for heat tolerance has great potential positively affect industry, as gains are permanent cumulative over generations. Rectal temperature (RT) hypothesized be good indicator trait tolerance. Therefore, this study investigated genetic architecture RT by estimating parameters, performing genome-wide association studies, biologically validating candidate genes identified...
Women show a higher prevalence for depression than men. However, the biological basis of gender differences in stress response and recovery still remain poorly understood. Therefore, aim study was to assess acute stress, chronic rats. Our results showed that decreased male body weight but had no effect on female Open field test demonstrated behavioral changes grooming velocity after recovery. Increased activity hypothalamic-pituitary-adrenocortical axis reflected by adrenal hypertrophy...
The objective of the present study was to estimate (co)variance components female fertility traits in Chinese Holsteins, considering different parities as traits. Data on 88,647 females with 215,632 records (parities) were collected during 2000 2014 from 32 herds Sanyuan Lvhe Dairy Cattle Center, Beijing, China. analyzed included interval calving first insemination, last days open, conception rate at number inseminations per and non-return rates within 56 after insemination.The descriptive...
Abstract Background The effect of heat stress on livestock production is a worldwide issue. Animal performance influenced by exposure to harsh environmental conditions potentially causing genotype-by-environment interactions (G × E), especially in highproducing animals. In this context, the main objectives study were (1) detect time periods which heifer fertility traits are more sensitive high temperature and/or humidity, (2) investigate G E due traits, and, (3) identify genomic regions...
Importance The reported phenotypes of men with 47,XXY and 47,XYY syndromes include tall stature, multisystem comorbidities, poor health-related quality life (HRQOL). However, knowledge about these sex chromosome aneuploidy (SCA) conditions has been derived from studies in the less than 15% patients who are clinically diagnosed also lack diversity age genetic ancestry. Objectives To determine prevalence undiagnosed X or Y among enrolled Million Veteran Program (MVP); to describe military...
Abstract Short-term mortality risk, which is indicative of individual frailty, serves as a marker for aging. Previous age clocks focused on predicting either chronological or longer-term mortality. Aging short-term are lacking and their algorithmic fairness remains unexamined. We developed deep learning model to predict 1-year using nationwide longitudinal data from the Finnish population (FinRegistry; n = 5.4 million), incorporating more than 8,000 features spanning up 50 years. achieved an...
High mortality and involuntary culling rates cause great economic losses to the worldwide dairy cattle industry. However, there is low emphasis on wellness traits in replacement animals (dairy calves heifers) during their development stages modern breeding programs. Therefore, main objectives of this study were estimate genetic parameters (replacement traits) obtain correlations with 12 cow health longevity Chinese Holstein population. Seven analyzed, including birth weight, survival from 3...