A5043596534- Oral microbiology and periodontitis research
- Metabolomics and Mass Spectrometry Studies
- Protease and Inhibitor Mechanisms
- Oral Health Pathology and Treatment
- Genetic Associations and Epidemiology
- Immune Response and Inflammation
- Dental Radiography and Imaging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Coagulation and Thrombosis Mechanisms
- Streptococcal Infections and Treatments
- BRCA gene mutations in cancer
- Dental Health and Care Utilization
- Sleep and related disorders
- HIV/AIDS oral health manifestations
- S100 Proteins and Annexins
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Salivary Gland Disorders and Functions
- Endodontics and Root Canal Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Imaging and Diagnostics
- Chronic Disease Management Strategies
- Bioinformatics and Genomic Networks
- Genetic factors in colorectal cancer
- Genomics and Rare Diseases
- Infective Endocarditis Diagnosis and Management
University of Helsinki
2015-2025
Helsinki University Hospital
2011-2025
Hospital District of Helsinki and Uusimaa
2020-2025
Karolinska Institutet
2017-2020
Helsinki Art Museum
2020
Institute for Molecular Medicine Finland
2017
Finnish Institute for Health and Welfare
2017
Medical University of Graz
2017
Aino University
2014
Abstract Aim Chronic periodontitis has an episodic and multifactorial character, with fluctuations in bacterial burden, inflammatory response, tissue destruction. We investigated the association of selected salivary biomarkers periodontal parameters validated use a novel diagnostic approach, cumulative risk score ( CRS ), detection subjects angiographically verified coronary artery disease diagnosis. Materials Methods The concentrations matrix metalloproteinase MMP )‐8, interleukin IL )‐1 β...
Missing teeth have been linked to incident cardiovascular disease, diabetes, and all-cause mortality. Our previous study revealed that signs of oral infections inflammatory conditions (i.e., periodontal disease dental caries) are associated with disadvantageous features circulating metabolites. This investigates whether missing tooth loss, the end points these diseases, similar metabolic features. The 2 Finnish population-based studies Health-2000 ( n = 6,197) FINRISK-97 6,050) were...
Our aim was to investigate the value of salivary concentrations four major periodontal pathogens and their combination in diagnostics periodontitis. The Parogene study included 462 dentate subjects (mean age 62.9±9.2 years) with coronary artery disease diagnosis who underwent an extensive clinical radiographic oral examination. Salivary levels bacteria were measured by quantitative real-time PCR. Median P. gingivalis, T. forsythia, intermedia, as well sum bacteria, higher moderate severe...
Systemic metabolic signatures of oral diseases have been rarely investigated, and prospective studies do not exist. We analyzed whether signs current or past infectious/inflammatory are associated with circulating metabolites. Two study populations were included: the population-based Health-2000 ( n = 6,229) Parogene 452), a cohort patients an indication to coronary angiography. participants 4,116) provided follow-up serum samples 11 y after baseline. Serum concentrations 157 metabolites...
Our aim was to analyze whether endotoxemia, i.e. translocation of LPS circulation, is reflected in the serum metabolic profile a general population and participants with cardiometabolic disorders. We investigated three Finnish cohorts separately meta-analysis ( n = 7178), namely population-based FINRISK97, FinnTwin16 consisting young adult twins, Parogene, random cohort cardiac patients. Endotoxemia determined as activity metabolome by an NMR platform. Potential effects body mass index...
Abstract 1 H NMR spectra of plasma are known to provide specific information on lipoprotein subclasses in the form complex overlapping resonances. A combination and self‐organising map (SOM) analysis was applied investigate if automated characterisation subclass‐related metabolic interactions can be achieved. To reliably assess intrinsic capability for resolving subclass profiles, sum representing pure part actual were simulated with aid experimentally derived model signals 11 distinct...
We investigated the association between Aggregatibacter actinomycetemcomitans serotypes, periodontal status and coronary artery disease (CAD).The study population included 497 patients who underwent angiography, clinical oral examination. Quantitative polymerase chain reaction assays were designed to identify serotypes from saliva samples.Aggregatibacter serotype frequencies as follows: "c" 35.7%, "b" 28.6%, "a" 26.2%, "e" 7.1%, "d" 2.4% "f" 0%. The subjects with a detectable had less teeth...
Matrix metalloproteinase 8 (MMP-8) is a proinflammatory enzyme expressed mainly by neutrophils. Elevated serum and plasma concentrations of MMP-8 are associated with the risk for outcome cardiovascular diseases (CVDs). The origin circulating not completely clear.We performed genome-wide association study levels in 2 populations comprising altogether 6049 individuals. Moreover, we studied whether MMP-8-associated variants linked to increased CVDs overall mortality >20 000 subjects. strongest...
Apical periodontitis is an inflammatory reaction at the apex of infected tooth. Its microbiota resembles that marginal and may induce local systemic antibodies binding to bacteria- host-derived epitopes. Our aim was investigate features adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical radiographic oral examination performed diagnose A three-category endodontic lesion score designed. Antibodies epitopes...
Abstract Aim To study whether oral parameters such as endodontic infections, root canal fillings, number of teeth or wearing removable dentures at baseline are associated with cardiovascular‐ and all‐cause mortality in a follow‐up approximately 8 years. Methodology The Finnish Parogene cohort consists 508 adults (mean age 63.3 years, SD 9.1) cardiac symptoms, all whom had undergone coronary angiography for accurate status. Extensive clinical radiographic examinations were performed,...
Background Translocation of lipopolysaccharide from gram‐negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected cardiometabolic disorders, such as cardiovascular diseases and obesity. Methods Results We performed a genome‐wide association study serum activity 11 296 individuals 6 different Finnish cohorts. Endotoxemia was measured by limulus amebocyte lysate assay whole population 2 other techniques (Endolisa...
The use of systemic antibiotics may influence the oral microbiota composition. Our aim was to investigate in this retrospective study whether prescribed associate with periodontal status, microbiota, and antibodies against pathogens. Social Insurance Institution Finland Data provided data on by record linkage purchased medications entitled reimbursements up 1 year before examination sampling. Six different classes were considered. Parogene cohort included 505 subjects undergoing coronary...
We examined the usefulness of dried spot blood and saliva samples in SARS-CoV-2 antibody analyses. analyzed 1231 self-collected from healthcare workers. Participants filled a questionnaire on their COVID-19 exposures, infections, vaccinations. Anti-SARS-CoV-2 IgG, IgA, IgM levels were determined both using GSP/DELFIA method. The level exposure was strongest determinant all classes increasing as follows: (1) no (healthy, non-vaccinated), (2) exposed, (3) former infection, (4) one vaccination,...
Various cell types in atherosclerotic lesions express matrix metalloproteinase (MMP)-8. We investigated whether MMP-8 affects the structure and antiatherogenic function of apolipoprotein (apo) A-I, main protein component HDL particles. Furthermore, we studied serum lipid profiles cholesterol efflux capacity MMP-8-deficient mouse model. Incubation apoA-I (28 kDa) with activated yielded 22 kDa 25 fragments. Mass spectrometric analyses revealed that was cleaved at its carboxyl-terminal part....
Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin-α polymorphisms associate with salivary biomarkers periodontal disease. A total 455 individuals detailed clinical radiographic health data were included study. 610 K genotyping chip Sequenom platform used analyses. Phospholipid transfer protein activity, concentrations lymphotoxin-α, IL-8 myeloperoxidase, cumulative score (combining Porphyromonas...
Chronic oral infection/inflammation is cross-sectionally associated with metabolic syndrome (MetS) in adults, but there are few longitudinal studies and on childhood infections adult MetS risk. We investigated whether clinical parameters indicative of were adulthood its components. A total 755 children aged 6, 9, 12 y underwent a examination 1980 as part the Cardiovascular Risk Young Finns Study. Oral health measures included bleeding probing (BOP), periodontal pocket depth, caries,...
The cumulative risk score (CRS) is a mathematical salivary diagnostic model to define an individual’s of having periodontitis. In order further validate this biomarker, we investigated how periodontal bacteria, lipopolysaccharide (LPS), and systemic local host immune responses relate CRS. Subgingival plaque, saliva, serum samples collected from 445 individuals were used in the analyses. Plaque levels 28 microbial species, especially those Aggregatibacter actinomycetemcomitans, Porphyromonas...
Abstract Aim To study the prevalence of carotid artery calcification (CAC) in relation to apical and marginal periodontitis, subgingival dysbiotic bacterial species serum saliva immune responses against them. In addition, aim was analyse association CAC with angiographically verified coronary disease (CAD) mortality. Methodology present random Parogene cohort, patients had an indication for angiography. Apical periodontitis were diagnosed during clinical radiographic oral examinations, on...
Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying relevant loci understanding their molecular biology could highlight new prevention management avenues. Our current oral health genomics suggests that dental caries periodontitis are polygenic diseases, very large sample sizes informative phenotypic measures required to discover signals adequately map associations across human genome. In this article, we introduce second wave...