Antti Hakanen
A5016961250- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Veterinary medicine and infectious diseases
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- Gut microbiota and health
- Orthopedic Infections and Treatments
- Pneumonia and Respiratory Infections
- Vibrio bacteria research studies
- Enterobacteriaceae and Cronobacter Research
- Infective Endocarditis Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Antibiotics Pharmacokinetics and Efficacy
- Colorectal Cancer Screening and Detection
- Appendicitis Diagnosis and Management
- Escherichia coli research studies
- Bacterial Infections and Vaccines
- Chronic Disease Management Strategies
- Respiratory viral infections research
- BRCA gene mutations in cancer
- Sleep and related disorders
University of Turku
2013-2025
Varsinais-Suomen Sairaanhoitopiiri
2021-2025
Turku University Hospital
2009-2024
Institute for Molecular Medicine Finland
2023
University of Helsinki
2023
Immunité et Cancer
2019
Finnish Institute for Health and Welfare
2009-2014
National Institutes of Health
2009-2012
CNR de la Résistance aux Antibiotiques
2009-2010
Public Health Institute
1999-2007
Abstract Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These survived the founding bottleneck rather than being distributed over large ultrarare variants. Although this effect is well established Mendelian genetics, its value common disease genetics less explored 1,2 . FinnGen aims to study genome and national health register data...
ABSTRACT Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles any gene is often concentrated on a small number low-frequency variants (0.1% ≤ minor allele frequency < 5%), which survived founding bottleneck, opposed to being distributed over much larger ultra--rare variants. While this advantage well-- established Mendelian genetics, its value common disease genetics has been less explored. FinnGen aims study genome and...
A genetic contribution to preeclampsia susceptibility has been established but is still incompletely understood.To disentangle the underlying architecture of and or other maternal hypertension during pregnancy with a genome-wide association study (GWAS) hypertensive disorders pregnancy.This GWAS included meta-analyses in combination phenotype encompassing disorders. Two overlapping groups were selected for examination, namely, pregnancy. Data from Finnish Genetics Pre-eclampsia Consortium...
Diarrhea is the most frequent health problem among children in developing countries. This study investigated bacterial and viral etiology related clinical epidemiological factors with acute diarrhea Ouagadougou, Burkina Faso. Stool specimens were collected from 283 under 5 years of age visiting hospital due to 60 healthy controls similar age. Pathogens by using conventional culture techniques, PCR immunochromatographic testing. Salmonella Shigella strains serotyped their susceptibility 23...
ObjectivesCarbapenemase-producing Enterobacteriaceae (CPE) are becoming a global problem; they often resistant to nearly all available antibiotics. Here we report details on Finnish CPE isolates found until the end of 2011: carbapenemase genes, travel history and multilocus sequence typing (MLST) data.
The Carba NP test was evaluated against a panel of 61 carbapenemase-producing bacterial species (15 producing class A carbapenemases, 15 D and 31 metallo-β-lactamases) 111 isolates with non-wild-type carbapenem susceptibility but not carbapenemase. Carbapenemase production verified by PCR UV-spectrophotometric measurement imipenem hydrolysis. No false positives were seen, there consistent problems the detection OXA-48-like enzymes also some rarer enzymes.
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms interactions environmental triggers in multi-ethnic sample 6,073 cases 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 DPB1*04:02) discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant at TRA DQB1*06:02 loci...
PURPOSE Family history (FH) and pathogenic variants (PVs) are used for guiding risk surveillance in selected high-risk women but little is known about their impact breast cancer screening on population level. In addition, polygenic scores (PRSs) have been shown to efficiently stratify through combining information common genetic factors into one measure. METHODS longitudinal real-life data, we evaluate PRS, FH, PVs stratified screening. Using FinnGen (N = 117,252), linked the Mass Screening...
ABSTRACT We evaluated 1,010 Salmonella isolates classified as fluoroquinolone susceptible according to the National Committee for Clinical Laboratory Standards guidelines susceptibility nalidixic acid and three fluoroquinolones. These were divided into two distinct subpopulations, with great majority ( n = 960) being fully ciprofloxacin a minority 50) exhibiting reduced (MICs ranging between 0.125 0.5 μg/ml). The less ciprofloxacin-susceptible uniformly resistant acid, while only 12 (1.3%)...
Abstract Large-scale biobank initiatives and commercial repositories store genomic data collected from millions of individuals, tools to leverage the rapidly growing pool health in disease prevention are needed. Here, we describe derivation validation genomics-enhanced risk for two common cardiometabolic diseases, coronary heart type 2 diabetes. Data used our analyses include FinnGen study (N = 309,154) UK Biobank project 343,672). The integrate contemporary genome-wide polygenic scores with...
BackgroundPoor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor respiratory has remained unclear. We examined if contributes as a factor to infections.MethodsWe used data on insomnia, influenza upper (URIs) from primary care hospital records in UK Biobank (N ≈ 231,000) FinnGen 392,000). computed logistic regression assess association infections, disease free survival hazard ratios, performed Mendelian randomization...
BACKGROUND: Adverse pregnancy outcomes (APO) contribute to higher risk of maternal cerebrovascular disease, but longitudinal data that include APO and stroke timing are lacking. We hypothesized associated with younger age at first stroke, a stronger relationship in those >1 APO. METHODS: analyzed Finnish nationwide health registry from the FinnGen Study. included women who gave birth after 1969 when hospital discharge was established. defined as affected by gestational hypertension,...
During 1995 to 1999, we collected 1,210 Salmonella isolates; 629 were from Finnish travelers returning abroad. These isolates tested for susceptibility by determining MICs ciprofloxacin, nalidixic acid, and seven additional antimicrobial agents. From the annual proportion of reduced ciprofloxacin (MIC > 0.125 microg/mL) among all travelers' increased 3.9% 23.5% (p<0.001). The increasing trend was outstanding Southeast Asia; Thailand alone 5.6% 50.0% fluoroquinolone nonclonal in character...
ABSTRACT Enterobacteria in fecal flora are often reported to be highly resistant. Escherichia coli is the main species; resistance data on other species rare. To assess effect of host's environment, antimicrobial was determined family Enterobacteriaceae from three populations: healthy people (HP)( n = 125) with no exposure antimicrobials for 3 months preceding sampling, university hospital patients (UP) ( 159) wards where antibiotic use 112 defined daily doses (DDD)/bed/month, and geriatric...
ABSTRACT There is a paucity of information regarding antimicrobial agents that are suitable to treat severe infections caused by multidrug-resistant Campylobacter spp. Our aim was identify potentially effective against multiresistant strains. The in vitro activities 20 238 strains were analyzed determining MICs the agar plate dilution method or Etest. These selected from 1,808 isolates collected Finnish patients between 2003 and 2005 screened for macrolide susceptibility using disk diffusion...
Objectives The common cold is the main cause of medical time loss in elite sport. Rapid diagnosis has been a challenge that may be amenable to molecular point-of-care testing (POCT). Methods We performed prospective observational study Team Finland during 2018 Winter Olympic Games. There were 44 athletes and 68 staff members. chief physician recorded symptoms daily on standardised form. Two nasal swabs taken at onset symptoms. One swab was analysed within 45 min using POCT for respiratory...
Uterine leiomyomata (UL) are the most common tumours of female genital tract and primary cause surgical removal uterus. Genetic factors contribute to UL susceptibility. To add understanding heritable genetic risk factors, we conduct a genome-wide association study (GWAS) in up 426,558 European women from FinnGen previous meta-GWAS. In addition 50 known loci, identify 22 loci that have not been associated with prior studies. UL-associated harbour genes enriched for development, growth,...
Although prostate cancer (PCa) is the most common in men Western countries, there significant variability geographical incidence. This might result from genetic factors, discrepancies screening policies, or differences lifestyle. Gut microbiota has recently been associated with progression, but its role PCa unclear. Characterization of gut and functions PCa. In a prospective multicenter clinical trial (NCT02241122), profiles 181 suspicion were assessed utilizing 16S rRNA sequencing....
Abstract Ciprofloxacin resistance was analyzed in 354 Campylobacter jejuni isolates collected during two study periods (1995–1997 and 1998–2000) from travelers returning to Finland. The increase between the significant among all (40% vs. 60%; p<0.01), as well those Asia alone (45% 72%; p<0.01).
Objectives: The resistance of Campylobacter jejuni to fluoroquinolones is increasing globally. This study was performed delineate those antimicrobial agents that are effective in vitro against ciprofloxacin-resistant C. isolates and potentially suitable for the treatment severe disease when fluoroquinolone or multidrug known suspected.
During a 9-year study period from 1997 through 2005, the association between antimicrobial resistance rates in Escherichia coli and outpatient consumption was investigated 20 hospital districts Finland. A total of 754,293 E. isolates, mainly urine samples, were tested for 26 clinical microbiology laboratories. The following antimicrobials studied: ampicillin, amoxicillin-clavulanate, cephalosporins, fluoroquinolones, trimethoprim, trimethoprim-sulfamethoxazole, pivmecillinam, nitrofurantoin....
Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning Thailand or Malaysia to Finland. A total of 10 isolates seven serovars studied in detail, all which had reduced susceptibility (MIC > = 0.125 microg/ml) ciprofloxacin but either susceptible showed only low-level < 32 nalidixic acid. Phenotypic characterization included testing by the agar dilution method and investigation efflux activity. Genotypic screening...
The agar dilution method has been standardized by the CLSI for susceptibility testing of Campylobacter species, and according to these standards, disk diffusion should be used only in screening macrolide ciprofloxacin resistance. Nevertheless, test is currently widely used, since it easy perform clinical microbiology laboratories. In this study, was compared analyzing vitro activities seven antimicrobial agents against 174 strains collected Finland between 2003 2008. Recommendations were...