A5001769465- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Maternal and fetal healthcare
- Gestational Diabetes Research and Management
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Neurological Complications and Syndromes
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
- Sodium Intake and Health
- Sex and Gender in Healthcare
- Obstructive Sleep Apnea Research
- Migraine and Headache Studies
- Pulmonary Hypertension Research and Treatments
- Hormonal Regulation and Hypertension
- Acute Myocardial Infarction Research
Cedars-Sinai Smidt Heart Institute
2021-2025
Cedars-Sinai Medical Center
2021-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
National Heart Lung and Blood Institute
2024
Christ Hospital
2023
National University of Singapore
2023
Health and Human Development (2HD) Research Network
2023
Columbia University Irving Medical Center
2015-2022
Anna Needs Neuroblastoma Answers
2021
Pasadena City College
2021
Obesity is a risk factor for various subtypes of cardiovascular disease (CVD), including coronary heart (CHD), failure (HF), and stroke. Nevertheless, there are limited comparisons the associations obesity with each these CVD subtypes, particularly regarding extent to which they unexplained by traditional mediators. We followed 13 730 participants in Atherosclerosis Risk Communities (ARIC) study who had body mass index ≥18.5 no at baseline (visit 1, 1987-1989). compared association higher...
Artificial intelligence (AI) has been developed for echocardiography1-3, although it not yet tested with blinding and randomization. Here we designed a blinded, randomized non-inferiority clinical trial (ClinicalTrials.gov ID: NCT05140642; no outside funding) of AI versus sonographer initial assessment left ventricular ejection fraction (LVEF) to evaluate the impact in interpretation workflow. The primary end point was change LVEF between or final cardiologist assessment, evaluated by...
<h3>Importance</h3> Hypertensive disorders of pregnancy are a leading cause maternal morbidity and mortality. The impact applying recent guideline definitions for nonpregnant adults to pregnant women is unclear. <h3>Objective</h3> To determine whether reclassification hypertensive status using the 2017 American College Cardiology/American Heart Association (ACC/AHA) definition better identifies at risk preeclampsia or eclampsia adverse fetal/neonatal events compared with current...
The effect of clinic-based intensive hypertension treatment on ambulatory blood pressure (BP) is unknown. goal the SPRINT (Systolic Blood Pressure Intervention Trial) BP ancillary study was to evaluate versus standard targets BP. Ambulatory obtained within 3 weeks 27-month visit in 897 participants. Intensive resulted lower clinic systolic (mean difference between groups=16.0 mm Hg; 95% confidence interval, 14.1–17.8 Hg), nighttime difference=9.6 7.7–11.5 daytime difference=12.3 10.6–13.9...
Risk factors for obstructive sleep apnea (OSA) and the development of subsequent cardiovascular (CV) complications differ by sex. We hypothesize that relationship between OSA high-sensitivity troponin T (hs-TnT), cardiac structure, CV outcomes differs sex.Seven hundred fifty-two men 893 women free disease participating in both Atherosclerosis Communities Sleep Heart Health Studies were included. All participants (mean age, 62.5 ± 5.5 years) underwent polysomnography measurement hs-TnT....
Background— Hospitalization for acute heart failure (HF) is associated with high rates of subsequent mortality and readmission. We assessed the influence time interval between previous HF hospitalization randomization in Candesartan Heart failure: Reduction Mortality morbidity (CHARM) trials on clinical outcomes patients both reduced preserved ejection fraction. Methods Results— CHARM enrolled 7599 New York Association class II to IV HF, whom 5426 had a history hospitalization. Cox...
Acute decompensated heart failure (ADHF) was a frequent common outcome in SPRINT (Systolic Blood Pressure Intervention Trial). We examined whether there differential reduction ADHF events from intensive blood pressure [BP] treatment among the 6 key, prespecified subgroups SPRINT: age ≥75 years, prior cardiovascular disease, chronic kidney women, black race, and 3 levels of baseline systolic BP (≤132 versus >132 to <145 ≥145 mm Hg).ADHF defined as hospitalization for ADHF, confirmed formally...
Background Racial disparities contribute to maternal morbidity in the United States. Hypertension is associated with poor outcomes, including stroke. Disparities hypertension might strokes. Methods and Results Using billing data from Healthcare Cost Utilization Project's National Inpatient Sample, we analyzed effect of race/ethnicity on stroke during delivery admission women aged 18 54 years delivering US hospitals January 1, 1998, through December 31, 2014. We categorized as normotensive,...
Individuals with diabetes mellitus and pre-diabetes are at particularly high risk of incident heart failure or death, even after accounting for known confounders. Nevertheless, the extent impairments in cardiac structure function elderly individuals is not well known. We aimed to assess relationship between echocardiographic measures dysglycemia.We assessed 4419 participants without prevalent coronary disease who attended Atherosclerosis Risk In Community (ARIC) visit 5 examination...
Guidelines recommend measuring out-of-clinic blood pressure (BP) to identify masked hypertension (MHT) defined by BP in the hypertensive range among individuals with clinic-measured not range. The aim of this study was determine overlap between ambulatory monitoring (ABPM) and home (HBPM) for detection MHT. We analyzed data from 333 community-dwelling adults taking antihypertensive medication clinic <140/90 mm Hg IDH (Improving Detection Hypertension). Any MHT presence daytime (mean...