A5006040852- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Pulmonary Hypertension Research and Treatments
- Diabetes Treatment and Management
- Health disparities and outcomes
- Genetic Associations and Epidemiology
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Sodium Intake and Health
- Dementia and Cognitive Impairment Research
- Cardiovascular Effects of Exercise
- Healthcare Policy and Management
Vanderbilt University Medical Center
2016-2025
Wayne State University
2005-2024
Detroit Medical Center
2013-2024
Vanderbilt University
2015-2024
Hutzel Women's Hospital
2023
VA Tennessee Valley Healthcare System
2021
University of Pennsylvania
2020
Krishna Institute of Medical Sciences
2020
Brigham and Women's Hospital
2012-2019
Harvard University
2013-2019
The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders,...
<h3>Importance</h3> Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening. <h3>Objective</h3> To determine whether a polygenic score improves prediction CHD compared with guideline-recommended clinical equation. <h3>Design, Setting, and Participants</h3> A retrospective cohort study the predictive accuracy previously validated was assessed among 4847 adults white European ancestry, aged...
Cardiovascular adverse events (CVAEs) can occur during proteasome inhibitor (PI) therapy. We conducted a prospective, observational, multi-institutional study to define risk factors and outcomes in patients with multiple myeloma (MM) receiving PIs.Patients relapsed MM initiating carfilzomib- or bortezomib-based therapy underwent baseline assessments repeated at regular intervals over 6 months, including cardiac biomarkers (troponin I T, brain natriuretic peptide [BNP], N-terminal proBNP),...
Dietary sodium recommendations are debated partly due to variable blood pressure (BP) response intake. Furthermore, the BP effect of dietary among individuals taking antihypertensive medications is understudied.
Rural populations experience an increased burden of heart failure (HF) mortality compared with urban populations. Whether HF incidence is greater among rural individuals less known. Additionally, the intersection between racial and health inequities understudied.
The complex relationship between left atrial (LA) structure and function, electrical burden of fibrillation (AF) stroke risk is not well understood. We aimed to describe LA function in AF.Left was assessed 971 subjects enrolled the echocardiographic substudy ENGAGE AF-TIMI 48. Left size, emptying fraction (LAEF), contractile were compared across AF types (paroxysmal, persistent, or permanent) CHADS2 scores as an estimate risk. majority patients (55%) had both enlargement reduced LAEF, with...
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome associated multiple pathophysiologic abnormalities, including left ventricular (LV) diastolic dysfunction, longitudinal LV systolic abnormal ventricular-arterial coupling, pulmonary hypertension, and right (RV) remodeling/dysfunction. However, the relative prognostic significance of each these abnormalities in HFpEF unknown.We prospectively studied 419 patients using echocardiography sphygmomanometry to assess...
The extent to which the relative contributions of traditional cardiovascular risk factors incident disease (CVD) may have changed over time remains unclear. We studied 13 541 participants (56% women, 26% black) in Atherosclerosis Risk Communities Study, aged 52 66 years and free CVD at exams 1987 through 1989, 1990 1992, 1993 1995, or 1996 1998. At each examination, we estimated population attributable risks (PAR) (hypertension, diabetes mellitus, obesity, hypercholesterolemia, smoking) for...
Background Recent data suggest that neighborhood socioeconomic environment predicts heart failure (HF) hospital readmissions. We investigated whether deprivation risk of incident HF beyond individual status in a low-income population. Methods and Results Participants were 27 078 whites blacks recruited during 2002 to 2009 the SCCS (Southern Community Cohort Study), who had no history using Centers for Medicare or Medicaid Services. Incident diagnoses through December 31, 2010, ascertained...
Renal dysfunction is a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). We sought to determine whether renal was associated measures of cardiovascular structure/function HFpEF. studied 217 participants from the PARAMOUNT study HFpEF who had echocardiography kidney function. evaluated relationships between [estimated glomerular filtration rate (eGFR) >30 <60 mL/min/1.73 m2 and/or albuminuria] structure/function. The mean age population 71 years, 55%...
Background Inflammation may contribute to incident heart failure ( HF ). Rheumatoid arthritis RA ), a prototypic inflammatory condition, serve as model for understanding inflammation‐related risk. Methods and Results Using the Vanderbilt University Medical Center electronic health record, we retrospectively identified 9889 patients with control without autoimmune disease matched age, sex, race. Prevalent at entry into record or preceding diagnosis was excluded. Incident ascertained using...
Background: NPs (natriuretic peptides) are cardiac-derived hormones that promote natriuresis, diuresis, and vasodilation. Preclinical evidence suggests nonhemodynamic triggers for NP release exist, with a few studies implicating inflammatory stimuli. We examined the association between inflammation levels in humans. Methods: The associations were 3 independent studies. First, 5481 MESA (Multi-Ethnic Study of Atherosclerosis) participants, cross-sectional (exam 1) longitudinal (exams 1 to 3)...
Although the development of abnormal myocardial mechanics represents a key step during transition from hypertension to overt heart failure (HF), underlying ultrastructural and cellular basis remains unclear. We therefore investigated how changes in transverse (T)-tubule organization resulting altered intracellular Ca(2+) cycling large cell populations underlie model chronic hypertension. Hearts spontaneously hypertensive rats (SHRs; n = 72) were studied at different ages stages disease early...
Individuals with diabetes mellitus and pre-diabetes are at particularly high risk of incident heart failure or death, even after accounting for known confounders. Nevertheless, the extent impairments in cardiac structure function elderly individuals is not well known. We aimed to assess relationship between echocardiographic measures dysglycemia.We assessed 4419 participants without prevalent coronary disease who attended Atherosclerosis Risk In Community (ARIC) visit 5 examination...