A5065189006- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Non-Invasive Vital Sign Monitoring
- Advanced MRI Techniques and Applications
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- Cardiovascular Health and Risk Factors
- Cardiovascular and exercise physiology
- Sleep and related disorders
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Health and Lifestyle Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Effects of Exercise
- Diabetes Management and Research
- Electrochemical sensors and biosensors
- Pancreatic function and diabetes
- TGF-β signaling in diseases
North Shore University Hospital
2023-2024
Northwestern University
2013-2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2023
Institute of Cardiology
2023
University of Illinois Chicago
2018-2023
Illinois College
2018-2023
University of Miami
2016-2023
Hofstra University
2023
Renal Research Institute
2019-2022
California State University, San Bernardino
2017-2022
The objective of this study was to evaluate whether heart rate variability (HRV) can be used as an index parasympathetic reactivation after exercise. Heart recovery exercise has recently been shown have prognostic significance and postulated related abnormal tone. Ten normal subjects [5 men 5 women; age 33 +/- yr (mean SE)] exercised their maximum capacity, 12 (10 2 61 10 yr) with coronary artery disease for 16 min on two separate occasions, once in the absence atropine (0.04 mg/kg)...
This study examines the prevalence of dementia in elderly Chinese aged 70 years and older Hong Kong using a two-phase design. In phase 1, 1,034 were interviewed with Cantonese version Mini-Mental State Examination. Those who scored below cutoff points subsample those scores normal range 2 to identify dementia. The overall weighted our subjects was 6.1 +/- 0.7%, which is at lower end rates reported whites. Alzheimer's disease (AD) accounted for 64.6% vascular dementia, 29.3%. Our results,...
Atrial 4D flow magnetic resonance imaging was used for the characterization of left atrial (LA) and appendage (LAA) dynamics in patients with fibrillation (AF).4D measured vivo 3D blood velocities 60 AF 15 controls. Anatomic maps LA LAA stasis velocity were calculated to quantify peak velocity, mean (velocities <0.1 m/s). In a substudy 30 patients, metrics compared Doppler transesophageal echocardiography. For all controls, consistently lower (by 21%/12%; P<0.001) while higher 58%; LA....
Background— Early repolarization, indicated on the standard 12-lead ECG, has recently been associated with idiopathic ventricular fibrillation in patients without structural heart disease. It is unknown whether there an association between early repolarization and arrhythmias coronary artery disease (CAD) population. Methods Results— Patients CAD implantable cardioverter-defibrillators healed phase of myocardial infarction were analyzed. In a case-control design, 60 who had arrhythmic events...
Background— Atrial fibrillation (AF) is commonly associated with congestive heart failure (CHF). The autonomic nervous system involved in the pathogenesis of both AF and CHF. We examined role remodeling contributing to substrate Methods Results— Electrophysiological mapping was performed pulmonary veins left atrium 38 rapid ventricular–paced dogs (CHF group) 39 control under following conditions: vagal stimulation, isoproterenol infusion, β-adrenergic blockade, acetylcholinesterase (AChE)...
Introduction : Dominant frequency (DF) analysis of atrial electrograms has been used to characterize fibrillation (AF). The aim this study was explore technical issues that may affect the estimation local activation rate during AF using DF analysis. Methods and Results: Epicardial recorded from 10 dogs were evaluate effects unipolar versus bipolar recordings, electrode spacing, postrecording processing, far field ventricular depolarizations, template subtraction, signal duration on Simulated...
Although frequency-domain analysis of heart rate variability (HRV) has been performed in the setting exercise and recovery from exercise, relationship specific frequency components to sympathetic parasympathetic inputs not validated this setting. The aim study is evaluate HRV modulation after using selective autonomic blockade. Normal subjects (n = 27, 17 men, 53 +/- 7 yr old) underwent bicycle stress testing on four separate days. On day 1, a baseline without blockade was performed. days 2...
Although the development of abnormal myocardial mechanics represents a key step during transition from hypertension to overt heart failure (HF), underlying ultrastructural and cellular basis remains unclear. We therefore investigated how changes in transverse (T)-tubule organization resulting altered intracellular Ca(2+) cycling large cell populations underlie model chronic hypertension. Hearts spontaneously hypertensive rats (SHRs; n = 72) were studied at different ages stages disease early...
Purpose: To use four‐dimensional (4D) flow MRI to characterize and quantify 3D blood in the left atria (LA) of patients with a history atrial fibrillation (AF). Materials Methods: The 4D was acquired 19 volunteers (n = 9<30 years, n 10>50 years) 10 AF (62 ± 9.6 years; 4 persistent AF, 6 postintervention). LA each dataset segmented, intra‐atrial velocity quantified. Flow coherence measured as consistency net vector. Results: Quantification revealed significant differences hemodynamics...
Objectives Left atrial (LA) 4-dimensional flow magnetic resonance imaging (MRI) was used to derive anatomic maps of LA stasis, peak velocity, and time-to-peak (TTP) velocity in patients with fibrillation (AF) identify relationships between volume patient characteristics. Materials Methods Four-dimensional MRI for the vivo assessment time-resolved 3-dimensional blood velocities performed 111 subjects: 42 a history AF sinus rhythm (AF-sinus), 39 persistent (AF-afib), 10 young healthy...
To apply 4D flow cardiac magnetic resonance (CMR) for the volumetric measurement of 3D left atrial (LA) blood to evaluate its potential detect altered LA in patients with fibrillation (AF) and investigate associations changes systolic diastolic current clinical risk score (CHA2DS2-VASc) used assessment thromboembolic AF.4D CMR was performed 40 a history AF (in sinus rhythm during scan, age = 61 ± 11 years), 20 age-appropriate controls (59 7 10 young healthy volunteers (24 2 years) measure...
The precise mechanisms by which oxidative stress (OS) causes atrial fibrillation (AF) are not known. Since AF frequently originates in the posterior left atrium (PLA), we hypothesized that OS, via calmodulin-dependent protein kinase II (CaMKII) signaling, creates a fertile substrate PLA for triggered activity and reentry. In canine heart failure (HF) model, OS generation oxidized-CaMKII-induced (Ox-CaMKII-induced) RyR2 Nav1.5 signaling were increased preferentially (compared with appendage)....
Fibrosis is an important structural contributor to formation of atrial fibrillation (AF) substrate in heart failure. Transforming growth factor-β (TGF-β) signaling thought be intricately involved creation fibrosis.We hypothesized that gene-based expression dominant-negative type II TGF-β receptor (TGF-β-RII-DN) the posterior left atrium a canine failure model will sufficiently attenuate fibrosis-induced changes conduction and restitution decrease AF. Because AF electrograms are reflect...
The parasympathetic (P) nervous system is thought to contribute significantly focal atrial fibrillation (AF). Thus we hypothesized that P nerve fibers [and related muscarinic (M(2)) receptors] are preferentially located in the posterior left atrium (PLA) and selective cholinergic blockade PLA can be successfully performed alter vagal AF substrate. PLA, pulmonary veins (PVs), appendage (LAA) from six dogs were immunostained for sympathetic (S) nerves, M(2) receptors. Epicardial...