A5020977961- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Biochemical Acid Research Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Genomics, phytochemicals, and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Metabolism and Genetic Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Hydrogen's biological and therapeutic effects
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Risk Factors
- Coenzyme Q10 studies and effects
- Cancer, Hypoxia, and Metabolism
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Free Radicals and Antioxidants
- Pomegranate: compositions and health benefits
Xi'an Jiaotong University
2016-2025
South China University of Technology
2025
Brigham and Women's Hospital
2015-2024
Harvard University
2015-2024
Ministry of Education of the People's Republic of China
2014-2024
Liaoning University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Shandong Academy of Sciences
2023-2024
Qilu University of Technology
2023-2024
Science and Technology Department of Sichuan Province
2023
The association between intake of fruits, vegetables, and legumes with cardiovascular disease deaths has been investigated extensively in Europe, the USA, Japan, China, but little or no data are available from Middle East, South America, Africa, south Asia.We did a prospective cohort study (Prospective Urban Rural Epidemiology [PURE] 135 335 individuals aged 35 to 70 years without 613 communities 18 low-income, middle-income, high-income countries seven geographical regions: North America...
Accumulation of oxidative damage to mitochondria, protein, and nucleic acid in the brain may lead neuronal cognitive dysfunction. The effects on function, mitochondrial structure, biomarkers were studied after feeding old rats two metabolites, acetyl- l -carnitine (ALCAR) [0.5% or 0.2% (wt/vol) drinking water], and/or R -α-lipoic (LA) [0.2% 0.1% (wt/wt) diet]. Spatial memory was assessed by using Morris water maze; temporal tested peak procedure (a time-discrimination procedure). Dietary...
Obesity is a major driver of cardiometabolic risk. Abdominal visceral adipose tissue (VAT) and sc (SAT) may confer differential metabolic risk profiles. We investigated the relations VAT SAT with factors in Jackson Heart Study cohort.
The responses to oxidative stress induced by chronic exercise (8-wk treadmill running) or acute (treadmill running exhaustion) were investigated in the brain, liver, heart, kidney, and muscles of rats. Various biomarkers measured, namely, lipid peroxidation [malondialdehyde (MDA)], protein oxidation (protein carbonyl levels glutamine synthetase activity), DNA damage (8-hydroxy-2′-deoxyguanosine), endogenous antioxidants (ascorbic acid, α-tocopherol, glutathione, ubiquinone, ubiquinol,...
The angiotensin-receptor-neprilysin inhibitor (ARNI) LCZ696 reduced cardiovascular deaths and all-cause mortality compared with enalapril in patients chronic heart failure the prospective comparison of ARNI an Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality Morbidity Heart Failure (PARADIGM-HF) trial. To more completely understand components this benefit, we examined effect mode death. PARADIGM-HF was a prospective, double-blind, randomized trial 8399 failure,...
Immobilization stress of male Spra- gue-Dawley rats induces oxidative damage to lipid, protein, and DNA in the brain. Significant increases lipid peroxidation were found cerebral cortex, cerebellum, hippocampus, midbrain compared unstressed controls. in-creases levels protein oxidation also hypothalamus, striatum, medulla oblongata. Oxidative nuclear increased after all brain regions, although only cortex showed a significant increase. Depletion glutathione some stimulation control stressed...
Abstract Chronic systemic exposure of D‐galactose to mice, rats, and Drosophila causes the acceleration senescence has been used as an aging model. However, underlying mechanism is yet unclear. To investigate mechanisms neurodegeneration in this model, we studied cognitive function, hippocampal neuronal apoptosis neurogenesis, peripheral oxidative stress biomarkers also protective effects antioxidant R‐α‐lipoic acid. mice (100 mg/kg, s.c., 7 weeks) induced a spatial memory deficit, increase...
Recent studies have revealed robust metabolic changes during cell differentiation. Mitochondria, the organelles where many vital reactions occur, may play an important role. Here, we report involvement of SIRT3-regulated mitochondrial stress in osteoblast differentiation and bone formation. In both line MC3T3-E1 primary calvarial osteoblasts, biogenesis supercomplex formation were observed differentiation, accompanied by increased ATP production decreased stress. Inhibition activity or...
Background Patients with heart failure and reduced ejection fraction have impaired health-related quality of life (HRQL) variable responses to therapies that target mortality hospitalizations. In PARADIGM-HF trial (Prospective Comparison ARNI [Angiotensin Receptor–Neprilysin Inhibitor] With ACEI [Angiotensin-Converting–Enzyme Determine Impact on Global Mortality Morbidity in Heart Failure), sacubitril/valsartan morbidity compared enalapril. Another major treatment goal is improve HRQL. Given...
Mitochondrial-supported bioenergetics decline and oxidative stress increases during aging. To address whether the dietary addition of acetyl- l -carnitine [ALCAR, 1.5% (wt/vol) in drinking water] and/or ( R )-α-lipoic acid [LA, 0.5% (wt/wt) chow] improved these endpoints, young (2–4 mo) old (24–28 F344 rats were supplemented for up to 1 mo before death hepatocyte isolation. ALCAR+LA partially reversed age-related average mitochondrial membrane potential significantly increased P = 0.02)...
A diet supplemented with (R)-lipoic acid, a mitochondrial coenzyme, was fed to old rats determine its efficacy in reversing the decline metabolism seen age. Young (3 5 months) and (24 26 were an AIN-93M or without acid (0.5% w/w) for 2 wk, killed, their liver parenchymal cells isolated. Hepatocytes from untreated vs. young controls had significantly lower oxygen consumption (P <0.03) membrane potential. (R)-Lipoic supplementation reversed age-related O2 increased Ambulatory activity, measure...
We test whether the dysfunction with age of carnitine acetyltransferase (CAT), a key mitochondrial enzyme for fuel utilization, is due to decreased binding affinity substrate and this substrate, fed old rats, restores CAT activity. The kinetics were analyzed by using brains young rats supplemented 7 weeks acetyl- l -carnitine (ALCAR) and/or antioxidant precursor R -α-lipoic acid (LA). Old compared showed decrease in activity CAT-binding both substrates, ALCAR CoA. Feeding or plus LA...
To understand better the cell and molecular basis for epidemiologic association between cigarette smoke, oxidant injury, age-associated macular degeneration, authors examined effects of acrolein, a major toxicant in on oxidative mitochondrial damage retinal pigment epithelial (RPE) cells reduction this by lipoic acid.Cultured human ARPE19 primary cultures fetal (hf)RPE were treated with acrolein. The toxicity acrolein protective R-alpha-lipoic acid variety previously described...
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) distribution among those predominantly African ancestry (AA). We performed GWAS WC and WHR, adjusted unadjusted for BMI, in up to 33,591 27,350 AA individuals, respectively. identified loci associated with individuals using meta-analyses GWA...