A5017645413- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Heart Failure Treatment and Management
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- Signaling Pathways in Disease
- Cardiovascular Effects of Exercise
- Peptidase Inhibition and Analysis
- Advanced MRI Techniques and Applications
- Pericarditis and Cardiac Tamponade
- Acute Myocardial Infarction Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Emergency and Acute Care Studies
- Healthcare Systems and Technology
- Reproductive System and Pregnancy
- Kawasaki Disease and Coronary Complications
- S100 Proteins and Annexins
- Lipoproteins and Cardiovascular Health
- Head and Neck Cancer Studies
- Cardiovascular Issues in Pregnancy
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac pacing and defibrillation studies
- Myasthenia Gravis and Thymoma
University of Wisconsin–Madison
2021-2024
Vanderbilt University Medical Center
2007-2020
Vanderbilt University
2007-2020
VA Tennessee Valley Healthcare System
2016-2018
National Institutes of Health
2018
Vanderbilt Health
2011
Cardiovascular Institute Hospital
2010
Medical University of South Carolina
2002
The utility of cardiac magnetic resonance imaging (MRI) as a screening tool for myocarditis in competitive student athletes returning to training after recovering from coronavirus disease 2019 (COVID-19) infection is unknown.To describe the prevalence and severity MRI findings population COVID-19.In this case series, an electronic health record search was performed at our institution (University Wisconsin) identify all (a consecutive sample) COVID-19, who underwent gadolinium-enhanced...
Background— Elevated levels of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor urokinase and tissue activator, are implicated in the pathogenesis fibrosis. Paradoxically, lack PAI-1 heart is associated with development cardiac fibrosis aged mice. However, molecular basis PAI-1–deficient mice unknown. Here, we investigated cellular bases myocardial Methods Results— Histological evaluation tissues derived from revealed resulting excessive accumulation collagen....
Background Inflammation may contribute to incident heart failure ( HF ). Rheumatoid arthritis RA ), a prototypic inflammatory condition, serve as model for understanding inflammation‐related risk. Methods and Results Using the Vanderbilt University Medical Center electronic health record, we retrospectively identified 9889 patients with control without autoimmune disease matched age, sex, race. Prevalent at entry into record or preceding diagnosis was excluded. Incident ascertained using...
The cytokine tumor necrosis factor (TNF)-alpha has been causally linked to left ventricular (LV) remodeling, but the molecular basis for this effect is unknown. Matrix metalloproteinases (MMPs) have implicated in cardiac remodeling and can be regulated by TNF-alpha. This study tested central hypothesis that administration of a TNF-alpha blocking protein would prevent induction MMPs alter course myocardial developing LV failure. Adult dogs were randomly assigned following groups: 1) chronic...
Objectives We examined the hypothesis that cardiac-specific troponin-I (cTn-I), a biomarker of myocardial injury, is elevated in patients with rheumatoid arthritis (RA). Background RA have an increased incidence heart failure (HF). Chronic injury may be mechanism for development HF. Methods compared cTn-I concentrations measured by high-sensitivity immunoassay 164 and 90 controls, excluding prior or active failure. relationship between cardiovascular risk factors, inflammation, coronary...
Reproductive age women (5-10%) are affected by the polycystic ovarian syndrome (PCOS), a diagnosis which confers lifelong cardiovascular and reproductive health implications. Plasminogen activator inhibitor-1 (PAI-1), main physiological inhibitor of plasminogen activation, is consistently elevated in with PCOS, regardless metabolic status. Interestingly, system has long been implicated proteolytic processes within dynamic ovary. A non-physiologic elevation PAI-1 may thus contribute...
Objective. The prevalence of heart failure is increased 2-fold in patients with rheumatoid arthritis (RA); this not explained by ischemic disease or other risk factors for failure. We hypothesized that RA without known disease, cardiac magnetic resonance imaging (cMRI) would detect altered structure, function, and fibrosis. Methods. performed 1.5-T cMRI 59 56 controls frequency-matched age, race, sex, compared indices fibrosis [late gadolinium enhancement (LGE), native T1 mapping,...
Background: Cardiac remodeling among individuals with heart failure preserved ejection fraction (HFpEF) and its risk factors is incompletely understood. Non-invasive cardiac imaging can reliably assess myocardial oxidative metabolism, perfusion, fibrosis, systolic diastolic function. Nevertheless, the interrelationships between these, particularly remain unresolved from health to HFpEF as most human studies lack complementary multi-modality imaging. Methods: We performed a cross-sectional...
Background The degree of aortic insufficiency (AI) after transcatheter valve replacement (TAVR) has been identified as a predictor increased mortality. Since even mild AI is associated with mortality in some studies, accurate quantification post-TAVR critical. Assessment by echocardiography typically performed visual inspection and semi-quantitative methods. Most paravalvular, however limited ability to quantify multiple eccentric paravalvular jets. Using flow methods, cardiac MRI (CMR) may...
Mass immunization campaigns continue in attempts to contain the ongoing COVID-19 pandemic. vaccines authorized for use United States include BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna), and JNJ-78436735 (Johnson & Johnson). To date multiple cases of vaccine-associated inflammation heart have been reported. In this work, we describe cardiac MRI findings 9 patients (adults children) with clinical imaging-based diagnosis myocarditis and/or pericarditis diagnosed shortly after mRNA...
Cardiac fibrosis is a common sequelae of cardiac injury and has deleterious functional consequences impacting filling, function rhythm. Plasminogen activator inhibitor-1 (PAI-1) been implicated in the pathogenesis tissue mice. To investigate longitudinal effect PAI-1 on structure function, M-mode echocardiography was employed to examine deficient (PAI-1 −/− ) wild-type (WT) control mice four age groups (6,12,18, 24 months). Eighteen month old exhibited reduced left ventricular (LV) diastolic...