Koichiro Kinugawa
A5038275040- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Electrolyte and hormonal disorders
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Heart Rate Variability and Autonomic Control
- Potassium and Related Disorders
- Ion Transport and Channel Regulation
- Diabetes Treatment and Management
- Hemodynamic Monitoring and Therapy
- Heart rate and cardiovascular health
- Cardiac Health and Mental Health
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Cardiovascular and exercise physiology
- Respiratory Support and Mechanisms
- Renal Transplantation Outcomes and Treatments
University of Toyama
2016-2025
Boehringer Ingelheim (United States)
2024
Pfizer (United States)
2024
Bayer (United States)
2024
Abbott (United Kingdom)
2024
Medtronic (Ireland)
2024
Medtronic (India)
2024
Toyama University Hospital
2016-2024
Japanese Circulation Society
2024
Second Hospital of Nanchang
2023
Abstract— Physiological and pathological cardiac hypertrophy have directionally opposite changes in transcription of thyroid hormone (TH)-responsive genes, including α- β-myosin heavy chain (MyHC) sarcoplasmic reticulum Ca 2+ -ATPase (SERCA), TH treatment can reverse molecular functional abnormalities hypertrophy, such as pressure overload. These findings suggest relative hypothyroidism but serum levels are usually normal. We studied the regulation receptors (TRs) β1, α1, α2 physiological...
Cytokines have significant roles in some cardiovascular disorders, but direct myocardial effects of cytokines remain to be elucidated. In the present study, we examined both early and delayed interleukin-6 (IL-6) on cultured chick embryo ventricular myocytes. Exposure these cells human recombinant IL-6 significantly decreased peak systolic [Ca2+]i (71.0 +/- 0.6% control value) amplitude cell contraction (66.0 7.4% within a few minutes. Pretreatment with NG-monomethyl-L-arginine (L-NMMA) or...
Background:Poor survival outcomes for patients with severe heart failure (HF) and the donor shortage transplantation warrant development of myocardial regenerative therapy. We performed a multicenter, phase II study to evaluate safety efficacy autologous skeletal myoblast sheets (TCD-51073).Methods Results:In 3 sites, we enrolled 7 chronic HF due ischemic disease despite maximal therapy, all whom underwent TCD-51073. No serious arrhythmia was reported, no changes were noted in frequency...
Background: A rapid heart rate (HR) during atrial fibrillation (AF) and flutter (AFL) in left ventricular (LV) dysfunction often impairs cardiac performance. The J-Land study was conducted to compare the efficacy safety of landiolol, an ultra-short-acting β-blocker, with those digoxin for swift control tachycardia AF/AFL patients LV dysfunction. Methods Results: 200 AF/AFL, HR ≥120beats/min, ejection fraction 25–50% were randomized receive either landiolol (n=93) or (n=107). Successful...
A newly-developed vasopressin type 2 receptor antagonist, tolvaptan (TLV), has a unique feature of diuresis, but the response to this drug can be unpredictable.Data were collected from hospitalized patients with decompensated congestive heart failure who administered TLV at 3.75-15 mg/day (n=61). responder/non-responder was determined as having any increase/decrease in urine volume (UV) during next 24h after treatment on first day. Logistic regression analyses for increases UV performed, and...
SA-I, SA-II *The morphofunctional phenotype description (M) may contain more information using standard abbreviations, such as AVB, atrioventricular block; WPW, Wolff-Parkinson-White syndrome; LQT, prolongation of the QT interval; AF, atrial fibrillation; ↓R, low electrocardiogram voltages; ↓PR, short PR interval.† Organ (O) involvement in addition to H subscript (for heart) should be expanded for M
The Impella
Postoperative development of aortic insufficiency (AI) after implantation left ventricular assist devices (LVADs) has recently been recognized, but the in previous reports have limited to HeartMate I or II. The purposes this study were determine whether AI develops with other types LVADs and elucidate factors associated AI.Thirty-seven patients receiving without evident abnormalities native valves enrolled (pulsatile flow LVAD [TOYOBO]: 76%, continuous [EVAHEART, DuraHeart, Jarvik2000, II]:...
Background: Little is known about health-related quality of life (QOL) in Japanese patients with heart failure. The purpose this study was to identify factors related QOL using a disease-specific instrument, and clarify whether independently predicts clinical outcomes among Methods Results: A total 114 outpatients failure were enrolled (mean age 64.7±15.8 years; 73.7% males). Minnesota Living Heart Failure Questionnaire (MLHFQ) assess patient's used. At baseline, depressive symptoms chronic...
Background:Preserved function of the renal collecting duct may be essential for response to vasopressin V2receptor antagonist, tolvaptan (TLV), but predictors TLV are unknown.Methods and Results:Sixty consecutive patients with stage D decompensated heart failure (HF) who had received on a de novo basis were retrospectively enrolled (TLV(+) group). Among them, 41 responders defined according urine volume (UV) increase after initiation. In UV-defined responders, plasma arginine (P-AVP) close...
Abstract Few studies have examined HRQOL in pediatric Tx recipients’ parents. This study investigated these parents and relationships between perceived burden of nurturing, family functioning, social support. Self‐report anonymous questionnaires a survey medical records were completed September December 2013. The SF ‐36v2, which evaluates physical, psychological, health, was used to measure . While values for physical psychological health higher than standard (Cohen's d = 0.34 0.17,...
Background: Loop diuretics are commonly used in heart failure (HF) patients, but they sometimes associated with insufficient response as well adverse events. In such diuretics-resistant cases, tolvaptan, a vasopressin type 2 receptor antagonist, shows the improvement of volume overload without electrolyte imbalance. Tolvaptan was launched Japan 2010, and post-marketing surveillance has been performed to evaluate safety efficacy tolvaptan real-world clinical settings. Methods Results: HF...
Abstract Aims Remote dielectric sensing (ReDS) represents a contemporary non‐invasive technique reliant on electromagnetic energy to quantify pulmonary congestion. Its prognostic significance within the context of heart failure (HF) patients remains elusive. This study aimed assess implications residual congestion, as gauged by ReDS system, among admitted due congestive HF. Methods and results We enrolled hospitalized HF who underwent assessments upon admission discharge in blinded manner,...
2 JCS/JSCVS/JCC/CVIT 2023 Guideline Focused Update on Indication and Operation of PCPS/ECMO/IMPELLA individual facilities.Therefore, in this Focus Update, specific classes or levels evidence are not strictly mandatory, but rather they presented as expert consensus.However, we strongly hope that will (1) serve a guideline for the standardization PCPS, ECMO, IMPELLA therapy within Japan, (2) be widely used by various healthcare professionals including physicians, nurses, clinical engineers,...
Background —We have previously demonstrated that changes in myosin heavy chain (MHC) isoforms occur failing human hearts resemble the pattern produced rodent myocardium response to hypothyroidism. Because thyroid hormone status is usually within normal limits these patients, we hypothesized failing/hypertrophied might a defect signaling due alterations expression of receptors (TRs). Methods and Results —To examine this hypothesis, used RNase protection assay measure mRNA levels TRs left...