A5015881279- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Vector-Borne Animal Diseases
- Cardiac Ischemia and Reperfusion
- Cardiovascular Issues in Pregnancy
- Acute Kidney Injury Research
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Mechanical Circulatory Support Devices
- Pregnancy and preeclampsia studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Viral Infections and Immunology Research
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Disease Prevention
Hokkaido University Hospital
2025
Nippon Medical School
2015-2025
Saitama Medical University
2023-2025
Social Insurance Saitama Chuo Hospital
2023-2025
Niigata University
2022-2023
Nippon Medical School Musashi Kosugi Hospital
2014-2022
Inserm
2014-2021
French Clinical Research Infrastructure Network
2021
Clinical Research Institute
2020
Assistance Publique – Hôpitaux de Paris
2018-2019
Increases in plasma B-type natriuretic peptide (BNP) concentrations those with acutely decompensated heart failure (ADHF) has been mainly attributed to an increase NPPB gene transcription. Recently, proBNP glycosylation emerged as a potential regulatory mechanism the production of amino-terminal (NT)-proBNP and BNP. The aim present study was investigate glycosylation, corin furin activities ADHF patients.Plasma levels proBNP, NT-proBNP, BNP, well concentration activity were measured large...
Kidney transplantation (KTx) is the best treatment for kidney failure, with better patient outcomes and cost efficiency.1 Despite expansion of organ donation, a severe shortage donors remains. Thus, proportion KTx in recipients preformed donor-specific anti-HLA antibodies (DSA) has increased.1 Recipients DSA usually require preconditioning treatments, such as rituximab, intravenous immunoglobulin (IVIG), plasma exchange to prevent antibody-mediated rejection (AMR). However, optimal...
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is vital for acute cardio-respiratory failure, but challenges persist sometimes in weaning. Prone positioning, beneficial veno-venous (VV-ECMO), generally avoided VA-ECMO patients because of the risks such as bleeding from catheter insertion site and dislodging perfusion cannula or tracheal tube. A 71-year-old male with paroxysmal atrial fibrillation (AF) presented dyspnoea. Chest computed tomography (CT) echocardiogram revealed...
Cardiovascular emergencies often require intensive care unit (ICU) management, but there is limited data comparing outcomes based on the admission ward. We analyzed from Japanese Registry of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database (2016-2020) for 715,054 patients (mean age, 75.4±14.2 years, 58.4% male) admitted with acute myocardial infarction (N=175,974), unstable angina (N=45,308), heart failure (N=179,871), aortic dissection (N=58,597),...
Abstract Data on human T‐cell lymphotropic‐virus‐type‐1 (HTLV‐I) status and hematology from 528 individuals were analyzed for associations with low reactivity to the purified protein derivative (PPD) of Mycobacterium tuberculosis recall antigen. Subjects classified as HTLV‐I carriers abnormal lymphocytes (Ably), without Ably, seronegatives. All had a significant 2.6‐fold risk being responders PPD compared seronegatives, Ably having highest relative risk. Carriers HTLV‐I‐antibody titer 1:256,...
The association between outcome and kidney injury detected at discharge from the ICU using different biomarkers remains unknown. objective was to evaluate 1-year survival discharge.Ancillary investigation of a prospective observational study.Twenty-one ICUs with follow-up.Critically ill patients receiving mechanical ventilation and/or hemodynamic support for least 24 hours were included.Serum creatinine, plasma Cystatin C, neutrophil gelatinase-associated lipocalin, urinary Proenkephalin A...
Abstract Sera from 1197 adult residents in Miyazaki district, an area Japan endemic for human T‐cell leukemia virus type I (HTLV‐I), were tested anti‐Tax antibody by the recombinant Tax (r‐Tax) Western blot assay. Among HTLV‐I‐seropositive individuals, including 21.5% of 484 males and 28.6% 713 females, prevalence 59.6% 58.3% respectively, with no apparent difference age. There was a significant 6‐fold among seropositive subjects titer > 1:8192 (84.6%) compared those lowest 1:16 (14.3%),...
Nitroxyl provokes vasodilatation and inotropic lusitropic effects in animals via post-translational modification of thiols. We aimed to compare the nitroxyl donor cimlanod (BMS-986231) with those nitroglycerin (NTG) or placebo on cardiac function patients chronic heart failure reduced ejection fraction (HFrEF).In a randomized, multicentre, double-blind, crossover trial, 45 stable HFrEF were given 5 h intravenous infusion cimlanod, NTG, separate days. Echocardiograms done at start end each...
To develop an experimental model of adult T‐cell leukemia/lymphoma in small animals, severe combined immunodeficiency (SCID) mice treated with anti‐asialo GM‐1 antibody were inoculated MT‐2 cells, a cell line transformed by the human leukemia virus (HTLV–I). Three injected 4 × 10 7 cells subcutaneously or intramuscularly developed tumors at near inoculation sites. Immunofluorescent (IFA) staining for HTLV–I structural protein, p19, revealed specific antigen cytoplasm most from and DNA...
Background: Acute heart failure syndrome (AHFS) remains a major clinical challenge because of its poor prognosis. Nicorandil, hybrid compound potassium-channel opener and nitric oxide donor, has been reported to improve the prognosis ischemic disease. We sought evaluate effect intravenous nicorandil on mid-term AHFS. Methods Results: A total 402 consecutive patients who were hospitalized for AHFS divided into 2 groups according use nicorandil: 78 in Nicorandil group 324 Control group. During...
The increasing burden and the continued suboptimal outcomes for patients with heart failure underlines importance of research to develop novel therapeutics this disorder. This can only be accomplished successful translation basic science discoveries into direct human application through effective clinical trial design execution that results in a substantially improved course outcomes. In respect, phase II trials play pivotal role determining which multitude potential should move large...
Patients with locally advanced head and neck cancer were treated concurrent chemoradiotherapy using three courses of cisplatin. However, many patients unable to complete the scheduled cisplatin treatment due adverse effects. The objective this study was retrospectively elucidate source low completion rate courses. Between November 2007 28 May 2010, curative intent according protocol (66–70 Gy at 2 Gy/day 80 mg/m2 on Days 1, 22 43). Treatment courses, hematological data other parameters...