A5072273353- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Climate Change and Health Impacts
- Nosocomial Infections in ICU
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- Intracranial Aneurysms: Treatment and Complications
- Chronic Kidney Disease and Diabetes
- Non-Invasive Vital Sign Monitoring
- Family and Patient Care in Intensive Care Units
- Bacterial Infections and Vaccines
- Trauma and Emergency Care Studies
- Malaria Research and Control
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Abdominal Surgery and Complications
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
Hôpital Antoine-Béclère
2020-2025
Assistance Publique – Hôpitaux de Paris
2009-2025
Université Paris-Sud
2021-2025
Hôpital Européen Georges-Pompidou
2024
Centre d'Investigation Clinique Hôpital Européen Georges Pompidou
2024
Université Paris-Saclay
2020-2022
French Clinical Research Infrastructure Network
2022
Inserm
2015-2022
Sorbonne Université
2021-2022
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2021-2022
Intensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor outcomes may prove useful in targeting an at-risk The main objective of study was identify clinical and biological determinants death year following discharge. FROG-ICU a prospective, observational, multicenter cohort followed 1 after discharge, including 21 medical, surgical or mixed ICUs France Belgium. All consecutive...
Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure a direct vasopressor requirement. In the present prospective observational multinational Outcome in Sepsis Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between bio-ADM initial intensive care unit (ICU) stay short-term outcome order to eventually design biomarker-guided randomized...
Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney and Septic Shock (Kid-SSS) study evaluated value proenkephalin A 119-159 (penkid)-a sensitive biomarker glomerular function, drawn within 24 hours upon intensive care unit (ICU) admission analyzed using a chemiluminescence immunoassay-for events sepsis septic shock.The Kid-SSS was substudy Adrenomedullin Outcome Severe (AdrenOSS) (NCT02393781), prospective, observational, multinational including...
The study objectives were to evaluate septic shock-induced alterations in skeletal muscle hemoglobin oxygenation saturation (StO2) using near-infrared spectroscopy (NIRS) and forearm skin blood flow velocity laser Doppler (LD) determine the relationship of macroperfusion microperfusion parameters, test worst NIRS parameters during first 24 hours shock with 28-day prognosis. A prospective, observational was performed a 21-bed university hospital surgical intensive care unit. Forty-three...
Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels circulating DPP3 (cDPP3) indicate high risk organ dysfunction mortality cardiogenic shock patients.The aim was to assess relationships between cDPP3 during initial intensive care unit (ICU) stay short-term outcome AdrenOSS-1, prospective observational multinational study twenty-four ICU centers five countries. AdrenOSS-1 included 585 patients admitted...
Rationale: Subclinical acute kidney injury (sub-AKI) refers to patients with low serum creatinine but elevated alternative biomarkers of AKI. Its incidence and outcome in critically ill remain, however, largely unknown. Plasma proenkephalin A 119-159 (penKid) has been proposed as a sensitive biomarker glomerular function.Objectives: In this ancillary study two cohorts, we explored the sub-AKI based on penKid.Methods: prospective observational ICUs was conducted. FROG-ICU (French European...
Abstract Background Respiratory syncytial virus (RSV) is one of the deadliest respiratory viruses. There a need to better identify prognostic factors in RSV-infected patients, particularly those requiring intensive care unit (ICU) admission, with focus on immunosuppressed patients. Methods Multicenter, retrospective cohort study adults hospitalized 17 ICUs Great Paris area between 08/01/2017 and 05/01/2023. The primary endpoint was all cause day 30 mortality. Supervised unsupervised analyses...
We studied COVID-19 associated mucormycosis based on 17 cases reported nationwide and assessed the differences with India. They differed by frequencies of diabetes mellitus (47% in France versus up to 95% India), hematological malignancies (35% 1%), anatomical sites (12% >80% rhino-orbito-cerebral) prognosis (88% mortality <50%).
The association between outcome and kidney injury detected at discharge from the ICU using different biomarkers remains unknown. objective was to evaluate 1-year survival discharge.Ancillary investigation of a prospective observational study.Twenty-one ICUs with follow-up.Critically ill patients receiving mechanical ventilation and/or hemodynamic support for least 24 hours were included.Serum creatinine, plasma Cystatin C, neutrophil gelatinase-associated lipocalin, urinary Proenkephalin A...
Introduction In critically ill patients undergoing prolonged mechanical ventilation (MV), the difference in long-term outcomes between with or without tracheostomy remains unexplored. Methods Ancillary study of a prospective international multicentre observational cohort 21 centres France and Belgium, including 2087 patients, one-year follow-up after admission. We included MV duration ≥10 days, tracheostomy. explored mortality classical Cox regression model (adjustment on age, SAPS II,...
Abstract Importance Information about the severity of Omicron is scarce. Objective To report respective risk ICU admission in patients hospitalized with Delta and variants to compare characteristics disease critically ill infected both according vaccination status. Design Analysis from APHP database, called Reality, prospectively recording following information consecutive admitted for COVID-19: age, sex, immunosuppression, vaccination, pneumonia, need invasive mechanical ventilation, time...
Necrotizing skin and soft tissue infections (NSTIs) are rare but serious rapidly progressive characterized by necrosis of subcutaneous tissue, fascia even muscle. The care pathway patients with NSTIs is poorly understood. A better characterization the trajectory these a identification at risk complicated evolution, requiring prolonged hospitalization, multiple surgical re-interventions, or readmission to intensive unit (ICU), an essential prerequisite improve their care. main objective this...
SCCM Pediatric Critical Care Medicine Explorations
Beyond sex, age, and various comorbidities, geographical origin socioeconomic deprivation are associated with Coronavirus Disease (COVID-19) morbidity mortality in the general population. We aimed to assess factors severe forms of COVID-19 after a hospital emergency department visit, focusing on factors.Patients laboratory-confirmed attending Béclère Hospital (France) March-April 2020 were included. Postal addresses used obtain two indices at neighborhood level. Factors hospitalization...
In shock, the increase in cutaneous-to-arterial carbon dioxide partial pressure (Pc-aCO2) and decrease perfusion index (PI) are related to macrovascular or microvascular alterations. We hypothesized that inducing cutaneous vasodilation local with heat could provide a noninvasive tool monitor reactivity.This study aimed develop approach, heating challenge (HC), reactivity of patients shock evaluate potential relationship outcome.After ethics committee agreement was obtained, 59 patients,...
Abstract Background Exposure of blood to malaria parasites can lead infection even in the absence mosquito vector. During a stay healthcare facility, accidental inoculation skin with from patient might occur, referred as nosocomial malaria. Methods Between 2007 and 2021, we identified 6 autochthonous cases that occurred different French hospitals, originating transmission imported being source. Four were observed during coronavirus disease 2019 pandemic. The genetic relatedness between...