A5006382948- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Neuropeptides and Animal Physiology
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Burn Injury Management and Outcomes
- Respiratory Support and Mechanisms
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
- Disaster Response and Management
- Airway Management and Intubation Techniques
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Vaccine Coverage and Hesitancy
- Thermal Regulation in Medicine
- Health, Medicine and Society
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Muscle and Compartmental Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Academic Publishing and Open Access
- Surgical Simulation and Training
Université Claude Bernard Lyon 1
2022-2025
Hospices Civils de Lyon
2022-2024
Inserm
2013-2023
Hôpital de la Croix-Rousse
2022-2023
Centre National de la Recherche Scientifique
2012-2023
Centre de Recherche en Cancérologie de Lyon
2022-2023
Centre Léon Bérard
2022-2023
Université Paris Cité
2013-2022
Hôpital Lariboisière
2014-2022
Hôpital Fernand-Widal
2017-2022
The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with preexisting cardiovascular disease, hypertension, related conditions incur disproportionately worse outcome. high infectivity of severe acute respiratory syndrome 2 is in part to new mutations the receptor binding domain, acquisition a furin cleavage site S-spike protein. continued viral shedding asymptomatic...
The prognostic power of circulating cardiac biomarkers, their utility, and pattern release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 with diagnosed COVID-19 admitted to 9 hospitals from December 31, March 4, 2020, estimate the associations injury markers poor outcomes COVID-19. mixed-effects Cox model, after adjusting for age, sex, comorbidities, adjusted hazard ratio 28-day mortality hs-cTnI...
Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure a direct vasopressor requirement. In the present prospective observational multinational Outcome in Sepsis Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between bio-ADM initial intensive care unit (ICU) stay short-term outcome order to eventually design biomarker-guided randomized...
The world is currently facing an unprecedented healthcare crisis caused by the COVID-19 pandemic. objective of these guidelines to produce a framework facilitate partial and gradual resumption intervention activity in context group has endeavoured minimum number recommendations highlight strengths be retained 7 predefined areas: (1) protection staff patients; (2) benefit/risk patient information; (3) preoperative assessment decision on intervention; (4) modalities preanaesthesia...
Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels circulating DPP3 (cDPP3) indicate high risk organ dysfunction mortality cardiogenic shock patients.The aim was to assess relationships between cDPP3 during initial intensive care unit (ICU) stay short-term outcome AdrenOSS-1, prospective observational multinational study twenty-four ICU centers five countries. AdrenOSS-1 included 585 patients admitted...
Introduction Sepsis remains a major health problem with an increasing incidence, high morbidity and mortality. Apart from treatment antibiotics organ support, no approved specific adjunct therapies currently exist. Adrenomedullin (ADM) is vasoactive peptide. High plasma concentrations of ADM correlate worse outcome in sepsis patients. Preclinical work the non-neutralising ADM-binding antibody adrecizumab showed promising effects animal models septic shock, including improved vascular barrier...
Acute hypotensive episodes (AHE), defined as a drop in the mean arterial pressure (MAP) <65 mm Hg lasting at least 5 consecutive minutes, are among most critical events intensive care unit (ICU). They known to be associated with adverse outcome critically ill patients. AHE prediction is of prime interest because it could allow for treatment adjustment predict or shorten AHE.The Super Learner (SL) algorithm an ensemble machine-learning that we specifically trained 10 minutes advance....
Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgently needed. Here we report that blood expression of IGFBP7 robustly increased in patients with HF an mouse model. In pressure overload model, Igfbp7 deficiency attenuated dysfunction reducing inflammatory injury, tissue fibrosis cellular senescence. promoted senescence stimulating...
Infections are a leading cause of early mortality after liver transplantation (LT). Prior to transplantation, cirrhosis-associated immune dysfunction significantly increases the risk infection. This study investigated potential monitoring, with focus on monocytic HLA-DR (mHLA-DR) expression, as predictor post-LT complications. We conducted prospective 130 patients awaiting LT at Lyon University Hospital assess mHLA-DR lymphocyte subsets, and T-cell function before LT. Multivariate analysis...
Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, may represent a novel treatment target in sepsis. The non-neutralizing ADM antibody adrecizumab has shown promising results preclinical sepsis models. In the present study, we investigated safety, tolerability pharmacokinetics (PK)/pharmacodynamics first-in-man study second during experimental human endotoxaemia.Forty-eight healthy male volunteers were enrolled two randomized, double-blind,...
To provide recommendations to facilitate the management of severe thermal burns during acute phase in adults and children. A committee 20 experts was asked produce six fields burn management, namely, (1) assessment, admission specialised centres, telemedicine; (2) haemodynamic management; (3) airway smoke inhalation; (4) anaesthesia analgesia; (5) wound treatments; (6) other treatments. At start recommendation-formulation process, a formal conflict-of-interest policy developed enforced...
Sepsis is a global economic and health burden. Dipeptidyl peptidase 3 (DPP3) elevated in the plasma of septic patients. The highest levels circulating DPP3 (cDPP3) are found non-survivor shock aim this study was to evaluate benefits inhibiting cDPP3 by specific antibody, Procizumab (PCZ), on cardiac function an experimental model sepsis, caecal ligature puncture (CLP) model. Rats were monitored invasive blood pressure echocardiography. Results presented as mean ± SD, with p <0.05 considered...
Myocarditis and pericarditis may constitute adverse reactions of mRNA coronavirus disease 2019 (COVID‐19) vaccines. This study aimed to document these assess the association with patient sex age. is as an observational retrospective using a case–non‐case design (also called disproportionality study) on inflammatory heart reported COVID‐19 vaccines within World Health Organization (WHO) global safety database (VigiBase), up June 30, 2021. Results are expressed reporting odds ratios (RORs)...
Abstract Background Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose this study was to assess in critical-care survivors the association between red blood cells and 1-year mortality. Methods FROG-ICU, a multicenter European enrolling all-comers critical care patients analyzed ( n = 1551). Association administered intensive unit mortality using an augmented inverse probability treatment weighting-augmented censoring weighting method control confounders. Results...
Impact of early systemic hemodynamic alterations and fluid resuscitation on outcome in the modern burn care remains controversial. We investigate association between acute-phase hemodynamics, timing critically ill patients. Retrospective, single-center cohort study was conducted a university hospital. Forty patients with total body surface area (TBSA) burn-injured >20 % invasive blood pressure cardiac output monitoring (transpulmonary thermodilution technique) within 8 h from trauma were...
Abstract Rationale The urinary proteome reflects molecular drivers of disease. Objectives To construct a proteomic biomarker predicting 1-year post-ICU mortality. Methods In 1243 patients, the was measured on ICU admission, using capillary electrophoresis coupled with mass spectrometry along clinical variables, circulating biomarkers (BNP, hsTnT, active ADM, and NGAL), albumin. included support vector modeling to classifier, Cox regression, integrated discrimination (IDI), net...
To provide guidelines to define the place of human factors in management critical situations anaesthesia and care. A committee nineteen experts from SFAR GFHS learned societies was set up. policy declaration links interest applied respected throughout guideline-producing process. Likewise, did not benefit any funding a company marketing health product (drug or medical device). The followed GRADE® method (Grading Recommendations Assessment, Development Evaluation) assess quality evidence on...
Sepsis still represents a major health issue, with persistent high morbidity and mortality rates. Cardiovascular dysfunction occurs frequently during sepsis. Adrenomedullin has been identified as key mediator in vascular tone regulation. A non-neutralizing anti-adrenomedullin antibody, Adrecizumab, may improve haemodynamic caecal ligation puncture-induced septic shock murine model. Our objective was to determine the role of Adrecizumab on haemodynamics rat model sepsis.For induction sepsis,...
Abstract Background Lumbar puncture (LP) is an invasive medical procedure that can be done by any doctor. Several simulation-based trainings have been built however the evaluations of theoretical knowledge and impact training never performed in real life. The objective was to evaluate a LP on improvement performance clinical practice. Methods Before after students’ training, confidence level were assessed. Over 6 months period, simulation evaluated success rate first carried out hospitalized...