A5087648305- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Cardiovascular Disease and Adiposity
- Renal function and acid-base balance
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Vitamin K Research Studies
- Transplantation: Methods and Outcomes
- Ophthalmology and Visual Impairment Studies
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Coronary Interventions and Diagnostics
- Retinal Imaging and Analysis
- Climate Change and Health Impacts
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Heavy metals in environment
- Noise Effects and Management
- Mercury impact and mitigation studies
Shanghai First People's Hospital
2014-2025
Shanghai Jiao Tong University
2017-2025
Jiangsu Provincial Center for Disease Control and Prevention
2019-2025
Southern Medical University
2022-2025
New York City College of Technology
2025
Children's Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Shanghai Ninth People's Hospital
2017-2024
South China Normal University
2024
The Cre/loxP system has become an important tool in designing postintegrational switch mechanisms for transgenes mice. power and spectrum of application this depends on transgenic mouse lines that provide Cre recombinase activity with a defined cell type-, tissue-, or developmental stage-specificity. We have developed novel line acts as reporter. mice, designated Z/EG (lacZ/EGFP), express lacZ throughout embryonic development adult stages. excision, however, removes the gene, which activates...
<h3>Importance</h3> Blood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal nonfatal outcomes. It uncertain which BP index most strongly associated with these <h3>Objective</h3> To evaluate the association of indexes death composite CV event. <h3>Design, Setting, Participants</h3> Longitudinal population-based cohort study 11 135 adults from Europe, Asia, South America baseline observations collected May 1988 to 2010 (last follow-ups, August...
The prostate-specific gene, TMPRSS2 is fused with the gene for transcription factor ERG in a large proportion of human prostate cancers. prognostic significance presence TMPRSS2:ERG fusion product remains controversial. We examined cancer specimens from 165 patients who underwent surgery clinically localised between 1998 and 2006. tested product, using RT–PCR direct sequencing. conducted survival analysis to determine on risk recurrence, adjusting established factors. discovered that was...
By inactivating the insulin-like growth factor receptor, IGFBP7 suppresses and promotes cell death.
Techniques of 2-dimensional speckle tracking enable the measurement myocardial deformation (strain) during systole. Recent clinical studies explored prognostic role left ventricular global longitudinal strain (GLS). However, there are few data on association between cardiovascular outcome and GLS in community. Therefore, we hypothesized that contains additive information over beyond traditional risk factors a large, population-based cohort.We measured by apical 4-chamber view 791...
Abstract Summary: Cre‐mediated site‐specific recombination allows conditional transgene expression or gene knockouts in mice. Inducible Cre systems have been developed to bypass initial embryonic lethal phenotypes and provide access later adult phenotypes. We produced transgenic mice which excision is tamoxifen inducible occurs a widespread mosaic pattern. utilized our reporter system combined with an stem (ES) cell screen identify ES clones undetectable background activity the absence of...
BACKGROUND MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression post‐transcriptionally. Dysregulation of miRNA has been implicated in the development and progression prostate cancer. Through next generation sequencing, we recently identified a panel five miRNAs associated with cancer recurrence metastasis. Of miRNAs, miR‐301a had strongest association recurrence. Overexpression cells, PC3, LNCaP resulted increased growth both vitro xenografted tumors. We therefore...
Background Experimental studies have demonstrated that lead and cadmium direct toxic effects on the myocardium, but few human are limited by design, assessment of exposure, use heart failure as a late‐stage endpoint. Methods Results In prospective population study, we studied association left ventricular ( LV ) function with blood (BPb) 24‐hour urinary (UCd). 179 participants randomly recruited from Flemish (50.3% women; mean age 39.1 years), geometric BP b UC d at enrollment (1985‐2000)...
BackgroundFollowing activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown.MethodsIn 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (eGFR [CKD-EPI formula]) stage of chronic kidney disease (CKD [KDOQI stages 2–3]) with inactive desphospho-uncarboxylated MGP (dp-ucMGP), using multivariable linear logistic...
Population data on the longitudinal changes of left ventricular (LV) structure and function in relation to insulin resistance are sparse. Therefore, we assessed a general population whether hyperinsulinemia predicts LV arterial characteristics.
Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from population cohorts. Subsequently, mortality and events recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (≤60, 61–70,...
Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of end points are tighter for central systolic BP (cSBP) than peripheral (pSBP) or pulse (cPP) (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 42.5 mm Hg, pSBP pPP 134.1 53.9 Hg. The primary composite point occurred 255 (4.5%). Across fourths cPP...
No previous study has addressed the relative contributions of environmental and genetic cues to diurnal blood pressure rhythmicity. From 24-hour ambulatory recordings systolic obtained in untreated patients (51% women; mean age, 51 years), we computed night-to-day ratio 897 morning surge 637. Environmental included season, daily outdoor temperature, atmospheric pressure, humidity weekday, 14 single nucleotide polymorphisms 10 clock genes. Systolic averaged (±SD) 126.7±11.9 mm Hg, 0.86±0.07,...
In a previous cross-sectional study, we identified multidimensional urinary classifier (HF1), which was associated with left ventricular dysfunction. We investigated whether HF1 predicts cardiovascular end points over and beyond traditional risk factors. 791 randomly recruited Flemish (mean age, 51.2 years; 50.6% women), quantified by capillary electrophoresis coupled mass spectrometry. addition, measured averaged −0.97 U (range, −3.26 to 2.60). Over 6.1 years (median), 35 participants died...
BackgroundIn view of the increasing heart failure epidemic and awareness adverse impact environmental pollution on human health, we investigated association left ventricular structure function with air pollutants in a general population.
Major adverse cardiovascular events are closely associated with 24-hour blood pressure (BP). We determined outcome-driven thresholds for mean arterial (MAP), a BP index estimated by oscillometric devices. assessed the association of major MAP, systolic (SBP), and diastolic (DBP) in population-based cohort (n=11 596). Statistics included multivariable Cox regression generalized R
BackgroundThe Global Burden of Diseases, Injuries, and Risk Factors Study 2019 called for innovation in addressing age-related disabilities. Our study aimed to identify validate a urinary peptidomic profile (UPP) differentiating healthy from unhealthy ageing the general population, test UPP predictor independent patient cohorts, search targetable molecular pathways underlying chronic diseases.MethodsIn this prospective population study, we used data participants Flemish on Environment, Genes...