A5014249691- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Sodium Intake and Health
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Nutritional Studies and Diet
- Acute Kidney Injury Research
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Renal function and acid-base balance
- Pregnancy and preeclampsia studies
- Electrolyte and hormonal disorders
- Pediatric Urology and Nephrology Studies
- Health, Medicine and Society
- Liver Disease and Transplantation
- Diet and metabolism studies
- Healthcare Systems and Practices
- Epigenetics and DNA Methylation
- Healthcare cost, quality, practices
- Coffee research and impacts
- Potassium and Related Disorders
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
University Hospital of Geneva
2016-2025
Hôpital Beau-Séjour
2012-2025
University of Geneva
2014-2024
University of Nevada, Reno
2024
Geneva College
2012-2023
Hypertension Institute
2022
Centre universitaire de médecine générale et santé publique, Lausanne
2020-2021
University of Lausanne
2014-2021
Institute of Social and Preventive Medicine
2013-2019
University Hospital of Lausanne
2013-2018
Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delays allograft function. Identification of factors that mediate protection and/or epithelium recovery could help to improve graft outcome. We studied the expression, regulation and role hypoxia inducible factor 1-alpha (HIF-1 α), using in vitro vivo experimental models I/R as well human post-transplant biopsies. found HIF-1 α is stabilized proximal tubule cells ischemia unexpectedly late...
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark diabetic kidney disease and associated with an increased risk for end-stage renal cardiovascular events. To gain insight into pathophysiological mechanisms underlying we conducted meta-analyses genome-wide association studies independent replication up to 5,825 individuals European ancestry diabetes 46,061 without diabetes, followed by functional studies. Known associations variants CUBN, encoding cubilin, urinary...
In the last decade, Acute Kidney Injury (AKI) diagnosis and therapy have not notably improved probably due to delay in diagnosis, among other issues. Precocity accuracy should be critical parameters novel AKI biomarker discovery. microRNAs are key regulators of cell responses many stimuli they can secreted extracellular environment. Therefore, detected body fluids emerging as disease biomarkers. We aimed identify validate serum miRNAs useful for management. Using qRT-PCR arrays samples, we...
Increased renal resistive index (RRI) has been recently associated with target organ damage and cardiovascular or outcomes in patients hypertension diabetes mellitus. However, reference values the general population information on familial aggregation are largely lacking. We determined distribution of RRI, factors, heritability a population-based study. Families European ancestry were randomly selected 3 Swiss cities. Anthropometric parameters risk factors assessed. A Doppler ultrasound was...
Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD hypertension general population. The factors uromodulin excretion normal population remain largely unknown, were therefore explored this study.Urinary was measured using a validated ELISA two population-based cohorts that included more than 6500 individuals. Swiss Kidney Project on Genes Hypertension study (SKIPOGH) 817 adults (mean age±SD, 45±17 years) who...
Abstract Introduction A systemic anticoagulation is often required to prevent circuit and filter clotting in ICU patients undergoing continuous renal replacement therapy (CRRT). regional citrate-based (RCA) does not induce a prolongs the lifespan, but metabolic side-effects have been associated with this therapy. We conducted randomized controlled trial requiring CRRT determine whether RCA using balanced predilution fluid more effective than heparin terms of delivered dose safety profile....
Increased pulse wave velocity (PWV) is a marker of aortic stiffness and an independent predictor mortality. Matrix Gla-protein (MGP) vascular calcification inhibitor that needs vitamin K to be activated. Inactive MGP, known as desphospho-uncarboxylated MGP (dp-ucMGP), can measured in plasma has been associated with various cardiovascular markers, outcomes, In this study, we hypothesized high levels dp-ucMGP are increased PWV. We recruited participants via multicenter family-based...
Abstract Clinical question What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and cardiovascular kidney outcomes for adults living with chronic disease (CKD)? Current practice Few therapies slow progression improve long term prognosis CKD. SGLT-2 have demonstrated benefits in CKD without type 2 diabetes. Existing guidance does not account totality current best evidence provide fully stratified treatment effects recommendations across all risk groups based...
Background. Data on long-term effects of acute kidney injury (AKI) renal function (RF) are scarce and factors implicated in the functional outcome not established. Our aim was to investigate these aspects. Methods. At hospital discharge annually for 10 years, we retrospectively reviewed RF 187 patients surviving AKI. Glomerular filtration rates estimated with MDRD equation (eGFR) KDOQI stages were used evaluate RF. Only 34.8% had pre-existing dysfunction (KDOQI-3). Variables determining...
Objective We investigated factors associated with masked and white-coat hypertension in a Swiss population-based sample. Methods The Kidney Project on Genes Hypertension is family-based cross-sectional study. Office 24-hour ambulatory blood pressure were measured using validated devices. Masked was defined as office pressure<140/90 mmHg daytime pressure≥135/85 mmHg. White-coat pressure≥140/90 pressure<135/85 Mixed-effect logistic regression used to examine the relationship of factors, while...
Urinary creatinine excretion is used as a marker of completeness timed urine collections, which are keystone several metabolic evaluations in clinical investigations and epidemiological surveys.
Preeclampsia is associated with increased cardiovascular and renal risk. The aim of this prospective cohort study was to characterize the early postpartum blood pressure (BP) profile after preeclampsia. We enrolled 115 women preeclampsia 41 a normal pregnancy in study. At 6 12 week postpartum, we assessed prevalence different hypertensive phenotypes using 24-hour ambulatory BP monitoring (ABPM), as well risk salt sensitivity variability derived from ABPM parameters. Among patients...
Chronic kidney disease (CKD) represents an increasing health burden. We present the population-based prevalence of CKD and compare Epidemiology collaboration (CKD-EPI) modification diet in renal (MDRD) equations to estimate glomerular filtration rate, using revised classification with three albuminuria classes. also explore factors associated CKD. The Swiss population-based, cross-sectional CoLaus study conducted Lausanne (2003–2006) included 2810 men 3111 women aged 35–75. was assessed...
Arginine vasopressin (AVP) has a key role in osmoregulation by facilitating water transport the collecting duct. Recent evidence suggests that AVP may have additional effects on renal function and favor cyst growth polycystic kidney disease. Whether also affects structure general population is unknown. We analyzed association of copeptin, an established surrogate for AVP, with parameters morphology multicentric population-based cohort. Participants from families European ancestry were...
ABSTRACT Aim Acute kidney injury (AKI) is a frequent complication in cirrhotic patients. As serum creatinine poor marker of renal function this population, we aimed to study the utility several biomarkers context. Methods A prospective was conducted hospitalized patients with decompensated cirrhosis. Serum (SCr), Cystatin C (CystC), NGAL and urinary NGAL, KIM‐1, protein, albumin sodium were measured on three separate occasions. Renal resistive index (RRI) obtained. We analyzed value these...
Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of end points are tighter for central systolic BP (cSBP) than peripheral (pSBP) or pulse (cPP) (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 42.5 mm Hg, pSBP pPP 134.1 53.9 Hg. The primary composite point occurred 255 (4.5%). Across fourths cPP...