A5100380374- Pain Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Multiple Myeloma Research and Treatments
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Anesthesia and Pain Management
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Colorectal Cancer Treatments and Studies
- Pharmacological Effects of Natural Compounds
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Blood groups and transfusion
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Plant-based Medicinal Research
- Renal Diseases and Glomerulopathies
- Complement system in diseases
Washington University in St. Louis
2018-2025
The University of Texas MD Anderson Cancer Center
2016-2025
National Clinical Research Center for Digestive Diseases
2025
Capital Medical University
2011-2025
Shanghai Clinical Research Center
2025
First Affiliated Hospital of Sichuan Medical University
2025
Affiliated Hospital of Southwest Medical University
2025
First Affiliated Hospital of Kunming Medical University
2025
Kunming Medical University
2025
Inner Mongolia Medical University
2025
With the emergence of manufactured nanomaterials, it is urgent to carry out researches on their potential environmental impacts and biological effects. To better understand ecotoxicological metal oxide nanoparticles released aquatic environments, zebrafish 96-h embryo-larval bioassay was used assess compare developmental toxicities nanoscale zinc (nZnO), titanium dioxide (nTiO2) alumina (nAl2O3) aqueous suspensions. Toxicological endpoints such as embryos or larvae survival, hatching rate...
Neuropathic pain encompasses a diverse array of clinical entities affecting 7-10% the population, which is challenging to adequately treat. Several promising therapeutics derived from molecular discoveries in animal models neuropathic have failed translate following unsuccessful trials suggesting possibility important cellular-level and differences between animals humans. Establishing extent potential laboratory humans, through direct study human tissues and/or cells, likely facilitating...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated sodium channel 1.7 (Na v 1.7) plays an important role in multiple preclinical models of neuropathic pain and inherited human phenotypes, its gene expression increased dorsal root ganglia (DRGs) paclitaxel-treated rats. Hence, the potential change function Na protein DRGs from male rats paclitaxel-related CIPN female humans...
Peripheral neuropathy is dose limiting in paclitaxel cancer chemotherapy and can result both acute pain during treatment chronic persistent survivors. The hypothesis tested was that produces these adverse effects at least part by sensitizing transient receptor potential vanilloid subtype 1 (TRPV1) through Toll-like 4 (TLR4) signaling. data show paclitaxel-induced behavioral hypersensitivity prevented reversed spinal administration of a TRPV1 antagonist. number + neurons increased the dorsal...
Chemotherapy-induced peripheral neuropathy (CIPN), characterized by pain and numbness in hands feet, is a common side effect of cancer treatment. In most patients, symptoms CIPN subside after treatment completion. However, substantial subgroup, persists long into survivorship. Impairment resolution pathways may explain persistent CIPN. We investigated the contribution T cells endogenous interleukin (IL)-10 to Paclitaxel-induced mechanical allodynia was prolonged T-cell-deficient (Rag1 −/− )...
Here, it is shown that paclitaxel-induced neuropathy associated with the development of spontaneous activity (SA) and hyperexcitability in dorsal root ganglion (DRG) neurons paralleled by increased expression low-voltage-activated calcium channels (T-type; Cav3.2). The percentage DRG showing SA overall mean rate were significantly higher at day 7 rats receiving paclitaxel treatment than vehicle. Cav3.2 was L4-L6 spinal cord segments paclitaxel-treated rats, localized to small calcitonin...
Tauopathy is a hallmark pathology of Alzheimer's disease with strong relationship cognitive impairment. As such, understanding tau may be key to clinical interventions. In vivo tauopathy has been measured using cerebrospinal fluid assays, but these do not provide information about where in the brain. The introduction PET ligands that bind paired helical filaments provides ability measure amount and distribution pathology. heritability age dementia onset tied specific mutations found...
Background Delirium is a common and serious postoperative complication, especially in the elderly. Epidural anesthesia may reduce delirium by improving analgesia, reducing opioid consumption, blunting stress response to surgery. This trial therefore tested hypothesis that combined epidural–general reduces incidence of elderly patients recovering from major noncardiac Methods Patients aged 60 90 yr scheduled for thoracic or abdominal surgeries expected last 2 h more were enrolled....
Neuropathic pain is a leading cause of high-impact pain, often disabling and poorly managed by current therapeutics. Here we focused on unique group neuropathic patients undergoing thoracic vertebrectomy where the dorsal root ganglia removed as part surgery allowing for molecular characterization identification mechanistic drivers independently preclinical models. Our goal was to quantify whole transcriptome RNA abundances using RNA-seq in pain-associated human from these patients,...
Abstract INTRODUCTION Blood tests have the potential to improve accuracy of Alzheimer's disease (AD) clinical diagnosis, which will enable greater access AD‐specific treatments. This study compared leading commercial blood for amyloid pathology and other AD‐related outcomes. METHODS Plasma samples from Disease Neuroimaging Initiative were assayed with AD C2N Diagnostics, Fujirebio ALZPath, Janssen, Roche Quanterix. Outcomes measures positron emission tomography (PET), tau PET, cortical...
Identifying the processes that determine initial mass function of stars (IMF) is a fundamental problem in star formation theory. One major uncertainties exact chemical state forming gas and its influence on dynamical evolution. Most simulations clusters use an isothermal equation (EOS). However, theoretical predictions observations suggest effective polytropic exponent gamma EOS varies with density. We address these issues study effect piecewise stellar turbulent, self-gravitating molecular...
Nociceptors, sensory neurons in the DRG that detect damaging or potentially stimuli, are key drivers of neuropathic pain. Injury to these causes activation translation regulation signaling, including mechanistic target rapamycin complex 1 (mTORC1) and mitogen-activated protein kinase interacting (MNK) eukaryotic initiation factor (eIF) 4E pathways. This is a mechanism driving changes excitability nociceptors critical for generation chronic pain states; however, mRNAs translated lead this...
Abstract SARS-CoV-2 has created a global crisis. COVID-19, the disease caused by virus, is characterized pneumonia, respiratory distress, and hypercoagulation can be fatal. An early sign of infection loss smell, taste, chemesthesis—loss chemical sensation. Other neurological effects have been described, but not explained. It now apparent that many these (for instance joint pain headache) persist for at least months after infection, suggesting sensory neuronal involvement in persistent...
Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic pain. During the initial stages following spinal injury, inflammation plays critical role; however, excessive exacerbate Regulatory T cells (Treg cells) have crucial function in regulating and alleviating Treg release suppressor cytokines modulate of other immune suppress inflammatory response. Simultaneously, impedes cell activity, further intensifying Therefore, suppressing response while enhancing...
Senescence restricts the development of applications involving mesenchymal stem cells (MSCs) in research fields, such as tissue engineering, and cell therapeutic strategies. Understanding mechanisms underlying natural aging processes may contribute to novel approaches preventing age-related diseases or slowing individual processes. Nampt is a rate-limiting NAD biosynthetic enzyme that plays critical roles energy metabolism, senescence maintaining life spans. However, it remains unknown...
Purpose Renal impairment (RI) limits treatment options in patients with relapsed/refractory multiple myeloma (RRMM). Here, we prospectively studied pomalidomide plus low-dose dexamethasone (LoDEX) RRMM and moderate or severe RI, including those receiving hemodialysis. Patients Methods MM-013, a noncomparative, European phase II trial, enrolled three patient cohorts: RI (cohort A; estimated glomerular filtration rate, 30 to < 45 mL/min/1.73 m2); B; that requires hemodialysis C). received 4...