A5009189002- Multiple Sclerosis Research Studies
- Iron Metabolism and Disorders
- Cytokine Signaling Pathways and Interactions
- Diabetes Management and Research
- Prenatal Screening and Diagnostics
- Diabetes Treatment and Management
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- Immunotherapy and Immune Responses
- Celiac Disease Research and Management
- Renin-Angiotensin System Studies
- Statistical Methods in Clinical Trials
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Alzheimer's disease research and treatments
- Nutrition, Genetics, and Disease
- Mitochondrial Function and Pathology
- Dietary Effects on Health
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
University of Rijeka
2015-2024
Centre of Research Excellence in Nutrition and Metabolism
2023
University Hospital Centre Zagreb
2023
Roche (Switzerland)
2018-2020
Centre Hospitalier Universitaire Amiens-Picardie
2017-2020
GTx (United States)
2017
University clinical center of Republika Srpska
2009
Novartis (Switzerland)
2005-2006
Eli Lilly (United States)
2003-2004
Eli Lilly (United Kingdom)
2000-2002
Abstract Background We previously investigated low doses (105 or 225 mg) of gantenerumab, a fully human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor-mediated phagocytosis, in the SCarlet RoAD (SR) Marguerite (MR) phase 3 trials. Several lines evidence suggested higher may be necessary to achieve clinical efficacy. therefore designed positron emission tomography (PET) substudy evaluate effect gantenerumab uptitrated 1200 mg every 4 weeks on plaques as...
Tauopathy is a hallmark pathology of Alzheimer's disease with strong relationship cognitive impairment. As such, understanding tau may be key to clinical interventions. In vivo tauopathy has been measured using cerebrospinal fluid assays, but these do not provide information about where in the brain. The introduction PET ligands that bind paired helical filaments provides ability measure amount and distribution pathology. heritability age dementia onset tied specific mutations found...
Objective: A novel treatment option for diabetic patients is the enhancement of incretin hormone activity by inhibition enzyme dipeptidyl peptidase‐4 (DPP‐4). This study was designed to establish a dose DPP‐4‐inhibitor vildagliptin (LAF237) that effective in reducing HbA1c levels and safe well tolerated with type 2 diabetes. Patients Methods: The 279 diabetes consisted 4‐week run‐in phase where received placebo 12‐week active they one following dosages vildagliptin: 25 mg twice daily, 25, 50...
Athletes and bodybuilders often misuse androgenic/anabolic steroids. When used in therapeutic doses, these drugs produce clinical jaundice just a small number of recipients. We present 26-year-old male bodybuilder who self-administered high doses steroids that induced liver damage. One month before admission to the hospital, he testosterone enanthate (500 mg intramuscularly, twice weekly), stanozolol (40 mg/d), methylandrostenediol (30 mg/d by mouth, for 5 weeks). On admission, his bilirubin...
The genetic etiology and the contribution of rare variation in multiple sclerosis (MS) has not yet been elucidated. Although familial forms MS have described, no convincing penetrant variants reported to date. We aimed characterize sporadic identified a family with two sibs affected by concomitant malignant melanoma (MM). performed whole exome sequencing this primary 38 multiplex families 44 cases transcriptional immunologic assessment variants. potentially causative homozygous missense...
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated the influence latitude on circadian rhythm and consequently genetic variability key regulators, ARNTL CLOCK genes, contribute to risk for sclerosis. Our aim was analyse selected polymorphisms CLOCK, their association A total 900 Caucasian patients 1024 healthy controls were compared signature at 8 SNPs, 4 each both genes. found a statistically significant difference...
Abstract The role of rare genetic variation and the innate immune system in etiology multiple sclerosis (MS) is being increasingly recognized. Recently, we described several variants NLRP1 gene, presumably conveying an increased risk for familial MS. In present study aimed to assess inflammasome regulatory network. We performed whole exome sequencing 319 probands, comprising patients with MS, sporadic MS control subjects. 62 genes involved NLRP1/NLRP3 regulation were screened potentially...
Abstract Aims To compare the effects of nateglinide plus metformin with gliclazide on glycaemic control in patients Type 2 diabetes. Methods Double‐blind, double‐dummy, parallel group, randomized, multicentre study over 24 weeks. Patients inadequate glucose maximal doses were randomized to additionally receive ( n = 133) or 129). Changes from baseline HbA 1c , fasting plasma (FPG) and mealtime insulin excursions examined. Results was significantly P < 0.001) decreased both treatment...
Lung cancer is a complex disease, and many factors, including environmental occupational exposure, cigarette smoking, genetics, contribute to its progression. Angiotensin-converting enzyme (ACE) an important regulator of blood pressure cardiovascular homeostasis. Plasma levels ACE depend on insertion/deletion (I/D) polymorphism in gene. Current correlation data between lung the I/D are contradictory or insufficient. We investigated whether associated with risk for development Croatian...
Abstract An investigation of body height and cephalic measurements was performed among five groups first‐year medical students the University Rijeka School Medicine (Rijeka, Croatia). Body different showed normal distribution, both in male female students. Differences between measured variables were statistically analyzed by ANOVA. No significant difference with regard to year birth found either males or females. The index no sexes height, while head breadth length correlated significantly...
Aim: To compare long‐term efficacy and safety of nateglinide plus metformin with those gliclazide in patients type 2 diabetes not adequately controlled monotherapy. Methods: Double‐blind, double‐dummy, multicentre study extended to a total 52 weeks. Patients inadequate glucose control on maximal doses were randomized (N = 133) or 129) add‐on treatment. After the initial 6‐month study, majority group [n 112 (93.3%)] 101 (92.7%)] entered 6‐month, double‐blind, extension study. Results: There...
Objective: Patients with type 2 diabetes most frequently use injections of premixed insulin formulations twice daily, but intensified therapy may provide better control. This study was designed to compare metabolic control three daily Humalog Mix50 or human 30/70 (30 % regular/70 NPH) in accordance normal prescription practice. Research Design and Methods: The cohort 40 patients used a two-way, crossover design. were randomized either at each main meal breakfast dinner for 3 months, followed...
Previous findings regarding the role of TNF-α-308 gene polymorphism in multiple sclerosis (MS) are contradictory. The aim this study was to investigate possible influence on MS susceptibility and disease process a Croatian Slovenian population. Genotyping performed 338 patients 460 healthy controls. TNF2 allele present 123 (26.8%) controls vs. 67 (19.9%) (p = 0.023, odds ratio 0.68, 95% confidence interval 0.48–0.95), suggesting that carriage might decrease risk. difference carrier frequency...
Objectives – Angiotensin-converting enzyme (ACE) activity is increased in blood and cerebrospinal fluid of patients with multiple sclerosis (MS). In addition, experimental autoimmune encephalomyelitis (EAE), an animal model MS, the blockade ACE suppresses disease itself. To analyze genetic association gene we examined insertion/deletion (I/D) polymorphism MS patients. Materials methods A total 313 from Slovenia Croatia 376 healthy controls were genotyped by polymerase chain reaction method....