Shaney Flores
A5079666204- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Bioinformatics and Genomic Networks
- MRI in cancer diagnosis
- Down syndrome and intellectual disability research
- Frailty in Older Adults
- Memory Processes and Influences
- Child and Animal Learning Development
- Chronic Disease Management Strategies
- Memory and Neural Mechanisms
- Health, Environment, Cognitive Aging
- Spatial Cognition and Navigation
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disease Mechanisms and Treatments
- Visual perception and processing mechanisms
- Lanthanide and Transition Metal Complexes
- Neural and Behavioral Psychology Studies
- Statistical Methods and Inference
- Mental Health Research Topics
Washington University in St. Louis
2016-2025
Mallinckrodt (United States)
2018-2024
Centre for Addiction and Mental Health
2024
Rice University
2024
Edinburgh College
2023
University of Edinburgh
2023
Columbia University Irving Medical Center
2023
Mallinckrodt (Ireland)
2023
University of Oxford
2023
Prevent Alzheimer’s Disease 2020
2021-2023
Macrophages are important players in the maintenance of tissue homeostasis1. Perivascular and leptomeningeal macrophages reside near central nervous system (CNS) parenchyma2, their role CNS physiology has not been sufficiently well studied. Given continuous interaction with cerebrospinal fluid (CSF) strategic positioning, we refer to these cells collectively as parenchymal border (PBMs). Here demonstrate that PBMs regulate CSF flow dynamics. We identify a subpopulation express high levels...
Tauopathy is a hallmark pathology of Alzheimer's disease with strong relationship cognitive impairment. As such, understanding tau may be key to clinical interventions. In vivo tauopathy has been measured using cerebrospinal fluid assays, but these do not provide information about where in the brain. The introduction PET ligands that bind paired helical filaments provides ability measure amount and distribution pathology. heritability age dementia onset tied specific mutations found...
Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against pathology, its effect on tau pathology and potential beneficial role people with disease still unclear. Our aim was study associations between dynamics soluble TREM2, as a biomarker signalling, amyloid β (Aβ) deposition, tau-related neuroimaging markers, cognitive decline,...
Abstract Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation amyloid-β (Aβ) peptide into plaques and microtubule protein tau neurofibrillary tangles (NFTs)—are hallmarks disease. However, other brain processes are thought to be key mediators Aβ plaque NFT pathology. How these additional pathologies evolve over course is currently unknown. Here we show that proteomic measurements in autosomal dominant AD...
Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. Successful use of this limited by the lack common standard quantification amyloid data. The Centiloid approach was recently proposed to address problem work, we report our implementation evaluate impact differences underlying image analysis methodologies using both cross-sectional longitudinal datasets. successfully converts quantitative burden measurements into scale (CL) comparable dynamic range. As...
Quantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence multiple imaging tracers presents challenges to interpretation such measurements. This study a direct comparison Pittsburgh compound B-based florbetapir-based same participants from two independent cohorts using crossover design.Pittsburgh B florbetapir PET data three different were analyzed previously established pipelines obtain global These measurements...
To remember everyday activity it is important to encode effectively, and one component of that consists events. People who segment into events more adaptively have better subsequent memory for activity, event boundaries are remembered than middles. The current study asked whether intervening improve segmentation by cuing effective would enhance We selected a set movies had previously been segmented large sample observers edited them provide visual auditory cues encourage segmentation. For...
"Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories. Advanced brain-predicted has been well established in symptomatic Alzheimer disease (AD), but is underexplored preclinical AD. Prior studies have typically used structural MRI, resting-state functional connectivity (FC) remains underexplored. Our model predicted from FC 391 cognitively normal, amyloid-negative controls (ages 18-89). We applied the trained 145 amyloid-negative, 151 AD, and 156...
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons case–control studies. age onset highly predictable within families, allowing researchers to estimate individual’s point the trajectory. These characteristics allow candidate...
Abstract Alzheimer’s disease biomarkers are crucial to understanding pathophysiology, aiding accurate diagnosis and identifying target treatments. Although the number of continues grow, relative utility uniqueness each is poorly understood as prior work has typically calculated serial pairwise relationships on only a handful markers at time. The present study assessed cross-sectional among 27 simultaneously determined their ability predict meaningful clinical outcomes using machine learning....
Alzheimer disease (AD) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it now acknowledged that neuroinflammation, particularly white matter (WM), significantly contributes to the development progression AD. This study aims investigate WM neuroinflammation continuum AD its association pathologies cognition using diffusion-based imaging (NII).
When people observe everyday activity, they spontaneously parse it into discrete meaningful events. Individuals who segment activity in a more normative fashion show better subsequent memory for the If segmenting events effectively leads to memory, does asking attend segmentation improve memory? To answer this question, participants viewed movies of naturalistic with instructions remember later test, and some conditions additionally pressed button or performed control condition that required...
African Americans are at greater risk for developing Alzheimer's disease (AD) dementia than non-Hispanic whites. In addition to biological considerations (eg, genetic influences and comorbid disorders), social environmental factors may increase the of AD dementia. This paper (1) assesses neuroimaging biomarkers amyloid (A), tau (T), neurodegeneration (N) potential racial differences (2) considers mediating effects socioeconomic status (SES) measures small vessel cardiovascular on observed...
To determine the characteristics of participants with amyloid-related imaging abnormalities (ARIA) in a trial gantenerumab or solanezumab dominantly inherited Alzheimer disease (DIAD).
Neurofilament light chain (NfL) is a protein that selectively expressed in neurons. Increased levels of NfL measured either cerebrospinal fluid or blood thought to be biomarker neuronal damage neurodegenerative diseases. However, there have been limited investigations relating the concurrent measures white matter (WM) decline it should reflect. White common feature Alzheimer's disease. We hypothesized serum would associate with WM lesion volume and diffusion tensor imaging (DTI) metrics...
This study aims to quantify microglial activation in individuals with Alzheimer disease (AD) using the 18-kDa translocator protein (TSPO) PET imaging hippocampus and precuneus, 2 AD-vulnerable regions, evaluate association of baseline neuroinflammation amyloidosis, tau, longitudinal cognitive decline.Twenty-four participants from Knight Disease Research Center (Knight ADRC) were enrolled classified into stable cognitively normal, progressor, symptomatic AD groups based on clinical dementia...
Abstract Neurofilament light chain, a putative measure of neuronal damage, is measurable in blood and CSF predictive cognitive function individuals with Alzheimer’s disease. There has been limited prior work linking neurofilament functional connectivity, no investigated associations connectivity autosomal dominant Here, we assessed relationships between light, cognition, cross-sectional sample 106 disease mutation carriers 76 non-carriers. We employed an innovative network-level enrichment...
Female sex is a major risk factor for late-onset Alzheimer disease (AD), and hormones have been implicated as possible protective factor. Neuroimaging studies that evaluated the effects of on brain integrity primarily emphasized neurodegenerative measures rather than amyloid tau burden.We compared cortical regional positron emission tomography (PET) deposition between cognitively normal males females. We also preclinical AD pathology females who not used hormone therapy (HT). Finally, we...
The apolipoprotein E ( APOE ) ε4 allele is strongly linked with cerebral β-amyloidosis, but its relationship tauopathy less established. We investigated the between carrier status, regional amyloid-β (Aβ), magnetic resonance imaging (MRI) volumetrics, tau positron emission tomography (PET), messenger RNA (mRNA) expression maps, and cerebrospinal fluid phosphorylated (CSF ptau 181 ). Three hundred fifty participants underwent imaging, 270 had . used computational models to evaluate main...