A5046330175- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Down syndrome and intellectual disability research
- HIV-related health complications and treatments
- Frailty in Older Adults
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Older Adults Driving Studies
- Bioinformatics and Genomic Networks
- Chronic Disease Management Strategies
- HIV Research and Treatment
- Urban Transport and Accessibility
- HIV/AIDS Research and Interventions
- Mental Health Research Topics
- Traffic and Road Safety
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Alcoholism and Thiamine Deficiency
- Infectious Encephalopathies and Encephalitis
- Science Education and Pedagogy
- Brain Metastases and Treatment
- Education and Critical Thinking Development
- Menopause: Health Impacts and Treatments
- Personality Disorders and Psychopathology
Washington University in St. Louis
2018-2025
John Wiley & Sons (United States)
2021
Hudson Institute
2021
Neurology, Inc
2020
Fayetteville Public Library
2018
Sleep monitoring may provide markers for future Alzheimer's disease; however, the relationship between sleep and cognitive function in preclinical early symptomatic disease is not well understood. Multiple studies have associated short long times with impairment. Since risk of change age, a greater understanding how cognition changes over time needed. In this study, we hypothesized that longitudinal will non-linear total time, spent non-REM REM sleep, efficiency slow wave activity. To test...
Background: Depression is also common with older age. Alzheimer’s disease (AD) studies suggest that both cerebrospinal fluid and positron emission tomography (PET) amyloid biomarkers are associated more depressive symptoms in cognitively normal adults. The recent availability of tau radiotracers offers the ability to examine vivo tauopathy. It unclear if biomarker depression diagnosis. Objective: We examined imaging were a diagnosis among adults (Clinical Dementia Rating = 0) whether...
Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes brain structure. It unknown if thickness and volumetric can identify AD stages they are similar to other genetic forms of AD. Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, 27 symptomatic). Cortical subcortical volumes compared between groups evaluated as a staging metric using receiver operating characteristic analyses. Thickness patterns those previously reported...
African Americans are at greater risk for developing Alzheimer's disease (AD) dementia than non-Hispanic whites. In addition to biological considerations (eg, genetic influences and comorbid disorders), social environmental factors may increase the of AD dementia. This paper (1) assesses neuroimaging biomarkers amyloid (A), tau (T), neurodegeneration (N) potential racial differences (2) considers mediating effects socioeconomic status (SES) measures small vessel cardiovascular on observed...
Abstract Introduction Continuous measures of amyloid burden as measured by positron emission tomography (PET) are being used increasingly to stage Alzheimer's disease (AD). This study examined whether cerebrospinal fluid (CSF) and plasma beta (Aβ)42/Aβ40 could predict continuous values for PET. Methods CSF Aβ42 Aβ40 were with automated immunoassays. Plasma an immunoprecipitation–mass spectrometry assay. Amyloid PET was performed Pittsburgh compound B (PiB). The relationships Aβ42/Aβ40...
Female sex is a major risk factor for late-onset Alzheimer disease (AD), and hormones have been implicated as possible protective factor. Neuroimaging studies that evaluated the effects of on brain integrity primarily emphasized neurodegenerative measures rather than amyloid tau burden.We compared cortical regional positron emission tomography (PET) deposition between cognitively normal males females. We also preclinical AD pathology females who not used hormone therapy (HT). Finally, we...
Abstract INTRODUCTION Trisomy 21, or Down syndrome (DS), predisposes individuals to early‐onset Alzheimer's disease (AD). While monoclonal antibodies (mAbs) targeting amyloid are approved for older AD patients, their efficacy in DS remains unexplored. This study examines positron emission tomography (PET) positivity (A+), memory function, and clinical status across ages guide mAb trial designs. METHODS Cross‐sectional data from the Alzheimer Biomarker Consortium–Down Syndrome (ABC‐DS) was...
Neurodegeneration is presumed to be the pathological process measure most proximal clinical symptom onset in Alzheimer Disease (AD). Structural MRI routinely collected research and trial settings. Several quantitative MRI-based measures of atrophy have been proposed, but their low correspondence with each other has previously documented. The purpose this study was identify which commonly used structural (hippocampal volume, cortical thickness AD signature regions, or brain age gap [BAG]) had...
Background: Frailty is an important clinical concern for the aging population of people living with HIV (PLWH). The objective this study was to identify combination risk features that distinguish frail from nonfrail individuals. Setting: Machine learning analysis highly dimensional performed on a cohort PLWH. Methods: Participants included 105 older (average age = 55.6) PLWH, at least 3-month history antiretroviral therapy (median CD4 546). Predictors demographics, markers, comorbid health...
<h3>Objective</h3> To evaluate temporal correlations between CSF and neuroimaging (PET MRI) measures of amyloid, tau, neurodegeneration in relation to Alzheimer disease (AD) progression. <h3>Methods</h3> A total 371 cognitively unimpaired impaired participants enrolled longitudinal studies AD had both (β-amyloid [Aβ]<sub>42</sub>, phosphorylated tau<sub>181</sub>, neurofilament light chain) (Pittsburgh compound B [PiB] PET, flortaucipir structural measures. The pairwise time interval was...
Development of Alzheimer's disease (AD) pathology in Down's syndrome (DS) occurs within a compressed timeline compared to sporadic or other genetic forms AD. Plasma glial fibrillary acidic protein (GFAP) and plasma pTau-217 levels were by AD pathophysiology (amyloid (A+) tau (T+) positron emission tomography [PET]) persons with DS (N = 348) sibling controls 42). GFAP, pTau-217, amyloid-PET, tau-PET regard estimated years onset clinical symptoms (52.5 old). We evaluated if GFAP mediated the...
Background: Changes in resting state functional connectivity (rs-fc) occur Alzheimer’s disease (AD), but few longitudinal rs-fc studies have been performed. Most focus on single networks and not a global measure of rs-fc. Although the amyloid tau neurodegeneration (AT(N)) framework is increasingly utilized by AD community, investigated when signature changes within this model. Objective: 1) Identify that differentiates cognitively normal (CN) individuals from symptomatic AD. 2) Assess...
Despite combined antiretroviral therapy, neuroinflammation may persist in persons living with HIV (PLWH) and contribute to cognitive impairment this population. Positron emission tomography (PET) imaging targeting 18 kDa translocator protein (TSPO) has been used localize neuroinflammation. We aimed use TSPO-PET evaluate PLWH.Twenty-four virologically suppressed PLWH on therapy 13 HIV-negative (HIV-) controls completed using the radiotracer [C]PBR28. Because of tracer complexity differing...
Background: Behavioral markers for Alzheimer’s disease (AD) are not included within the widely used amyloid-tau-neurodegeneration framework. Objective: To determine when falls occur among cognitively normal (CN) individuals with and without preclinical AD. Methods: This cross-sectional study recorded CN participants (n = 83) over a 1-year period. Tailored calendar journals falls. Biomarkers including amyloid positron emission tomography (PET) structural functional magnetic resonance imaging...
Determining whether neurofilament light chain (NfL) elevations in patients who develop immune effector cell-associated neurotoxicity syndrome (ICANS) occur before or after infusion of cellular product is important to identify high-risk and inform neuroaxonal injury latent a consequence treatment.
Abstract Background While antiretroviral therapy (ART) has improved outcomes for people with HIV (PWH), brain dysfunction is still evident. Immune activation and inflammation remain elevated in PWH receiving ART, thereby contributing to morbidity mortality. Previous studies demonstrated reduced functional structural changes PWH; however, underlying mechanisms elusive. Methods Our cohort consisted of ART adherence viral suppression ( &lt; 50 copies/mL; N = 173). Measurements included...
Abstract INTRODUCTION Cerebrospinal fluid (CSF) tau phosphorylation at multiple sites is associated with cortical amyloid and other pathologic changes in Alzheimer's disease. These relationships can be non‐linear. We used an artificial neural network to assess the ability of 10 different CSF predict continuous positron emission tomography (PET) values. METHODS occupancies (including pT181/T181, pT217/T217, pT231/T231 pT205/T205) were measured by mass spectrometry 346 individuals (57...
Abstract INTRODUCTION As the number of biomarkers used to study Alzheimer's disease (AD) continues increase, it is important understand utility any given biomarker, as well what additional information a biomarker provides when compared others. METHODS We hierarchical clustering group 19 cross‐sectional in autosomal dominant AD. Feature selection identified that were strongest predictors mutation status and estimated years from symptom onset (EYO). Biomarkers included clinical assessments,...
Abstract Background This study examined the effects of human immunodeficiency virus (HIV) on resting state functional connectivity (RSFC) in a large cohort people with HIV (PWH) and healthy controls without (PWoH). Within PWH analyses focused viral suppression cognitive impairment RSFC. Methods A total 316 stable combination antiretroviral therapy 209 demographically matched PWoH were scanned at single institution. Effects by grouping detectable (viral load &gt; 20 copies/mL; VLD)...
Abstract Background Persons with HIV (PWH) are at increased risk of frailty, a clinically recognizable state vulnerability resulting from aging-associated decline in multiple physiologic systems. Frailty is often defined by the Fried criteria, which includes subjective and objective standards concerning health resiliency. However, these frailty metrics do not incorporate cognitive performance or neuroimaging measures. Methods We compared structural (diffusion tensor imaging [DTI]) functional...
Background: Individuals with Alzheimer’s disease (AD) are more than twice as likely to incur a serious fall the general population of older adults. Although AD is commonly associated cognitive changes, impairments in other clinical measures such strength or functional mobility (i.e., gait and balance) may precede symptomatic impairment preclinical lead increased risk. Objective: To examine mechanisms mobility, cognition, biomarkers) falls cognitively normal Methods: This 1-year study was...