A5084167089- HIV-related health complications and treatments
- HIV Research and Treatment
- Advanced Neuroimaging Techniques and Applications
- CAR-T cell therapy research
- Dementia and Cognitive Impairment Research
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Functional Brain Connectivity Studies
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Frailty in Older Adults
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- HIV/AIDS drug development and treatment
- Nutrition and Health in Aging
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- Bone and Joint Diseases
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Neurological Complications and Syndromes
St Nicholas Hospital
2025
Duke University
2025
Washington University in St. Louis
2017-2024
Fate Therapeutics (United States)
2020-2023
University of Minnesota Medical Center
2014-2022
Saint Louis University
2020
University of Minnesota
2009-2019
Neurology, Inc
2018
Minnesota Oncology
2017
University of Missouri–St. Louis
2014-2016
Volcanic provinces are among the most active but least well understood landscapes on Earth. Here, we show that central Cascade arc, USA, exhibits systematic spatial covariation of topography and hydrology linked to aging volcanic bedrock, suggesting controls landscape evolution. At crest, a locus Quaternary volcanism, water circulates deeply through upper [Formula: see text]1 km crust transitions shallow dominantly horizontal flow as rocks age away from arc front. We argue this pattern...
The Montreal Cognitive Assessment (MoCA) is a brief screening measure commonly used to determine cognitive status among older adults. Despite the popularity of MoCA, there has been little research into how performance on MoCA changes over time in healthy adults.The present study examined sample adults (n = 53) recruited for longitudinal aging. Change total score at three points (baseline, 12 months, and 48 months) scores from Repeatable Battery Neuropsychological Status five (RBANS; baseline...
This study investigated the impact of pretransplant cytomegalovirus (CMV) serostatus and posttransplant CMV reactivation disease on umbilical cord blood transplant (UCBT) outcomes. Between 1994 2007, 332 patients with hematologic malignancies underwent UCBT 54% were seropositive. Pretransplant recipient had no acute or chronic graft-versus-host (aGVHD, cGVHD), relapse, disease-free survival (DFS), overall (OS). There was a trend toward greater day 100 treatment-related mortality (TRM) in...
Persons with human immunodeficiency virus (PWH) are characterized by altered brain structure and function. As they attain normal lifespans, it has become crucial to understand potential interactions between (HIV) aging. However, remains unclear how aging varies viral load (VL).
The advent of chimeric antigen receptor (CAR) T cell therapies has transformed the treatment hematological malignancies; however, broader therapeutic success CAR cells been limited in solid tumors because their frequently heterogeneous composition. Stress proteins MICA and MICB (MICA/B) family are broadly expressed by tumor following DNA damage but rapidly shed to evade immune detection.
This study examined the relative contribution of cognitive status to frailty among older individuals infected with HIV+.Participants included 122 HIV+ [mean age = 57.5 (6.6)] a median CD4 cell count 546. Undetectable viral load (<50 copies per mL) was observed in 94% sample. The sample defined as frail (n 21) and nonfrail 101) according Fried phenotype criteria. Cognitive tests measures executive function, motor/psychomotor, language, learning, memory. Performances were converted...
Neuropsychiatric symptoms have been reported in people living with HIV (PLWH) on integrase strand transfer inhibitors (INSTIs) postmarketing analysis. Limited data exist regarding brain integrity (function and structure) PLWH prescribed INSTIs compared other treatment regimens.A cross-sectional analysis of combined antiretroviral therapy aged more than 18 years at a single institution.Neuropsychological tests were administered to calculate domain deficit scores learning/memory, executive...
People living with HIV (PLWH) may be at higher risk for adverse outcomes indirectly associated the severe acute respiratory syndrome coronavirus (SARS-CoV-2). When comparing responses to questionnaires administered when social distancing and quarantine guidelines were first implemented, we found that PLWH more likely have restricted access medical care, increased financial stress, symptoms of anxiety depression, substance use compared demographically-similar people without HIV.
7541 Background: FT516 is an investigational, NK cell cancer immunotherapy derived from a clonal master iPSC line. engineered with novel hnCD16 Fc receptor, demonstrated preclinically to maximize antibody-dependent cellular cytotoxicity (Zhu et al. Blood 2020). can be mass produced and made available off-the-shelf for broad pt access multi-dose administration. Methods: This Phase I trial of combined rituximab (R) in pts R/R BCL. Treatment consists 2 cycles, each 3 days lympho-conditioning...
Background: Frailty is an important clinical concern for the aging population of people living with HIV (PLWH). The objective this study was to identify combination risk features that distinguish frail from nonfrail individuals. Setting: Machine learning analysis highly dimensional performed on a cohort PLWH. Methods: Participants included 105 older (average age = 55.6) PLWH, at least 3-month history antiretroviral therapy (median CD4 546). Predictors demographics, markers, comorbid health...
Objective: Neurofilament light chain protein (NfL) is a marker of neuronal injury and neurodegeneration. Typically assessed in cerebrospinal fluid, recent advances have allowed this biomarker to be more easily measured plasma. This study assesses plasma NfL people with HIV (PWH) compared without (PWoH), its relationship cognitive impairment, cardiovascular risk, neuroimaging metric brain aging [brain-age gap (BAG)]. Design: One hundred four PWH (HIV RNA <50 copies/ml) 42 PWoH provided...
Objective: This study examined whether the revised VACS2.0 index (including serum albumin, body mass (BMI), and white blood cell (WBC) count) had stronger correlations with cognitive function, brain volume, frailty in PWH ≥ 50 years compared to VACS1.0. Design Methods: Neuropsychological performance (NP) Z-scores (learning, retention, executive functioning (EF), psychomotor function/processing speed (PM/PS), language, global cognition), neuroimaging measures (brain volumetrics) were analyzed...
<h3>Background</h3> FT500 is an investigational, off-the-shelf NK cell cancer immunotherapy derived from a human clonal master iPSC line, renewable source which innate effector cells can be mass produced and made available for broad patient access multiple dose administration. has potent cellular cytotoxicity as compared to sourced healthy donors been shown synergize with T anti-PD-1 blockade in preclinical studies.<sup>1</sup> <h3>Methods</h3> being investigated Phase I clinical trial...
Despite combined antiretroviral therapy, neuroinflammation may persist in persons living with HIV (PLWH) and contribute to cognitive impairment this population. Positron emission tomography (PET) imaging targeting 18 kDa translocator protein (TSPO) has been used localize neuroinflammation. We aimed use TSPO-PET evaluate PLWH.Twenty-four virologically suppressed PLWH on therapy 13 HIV-negative (HIV-) controls completed using the radiotracer [C]PBR28. Because of tracer complexity differing...
Objective: This study examined relationships between anticholinergic medication burden and brain integrity in people living with HIV (PLWH) without (HIV−). Methods: Neuropsychological performance z -scores (learning, retention, executive function, motor/psychomotor speed, language domains, global cognition), neuroimaging measures (brain volumetrics white matter fractional anisotropy) were analyzed PLWH ( n = 209) HIV− 95) grouped according to the Anticholinergic Cognitive Burden (ACB) scale...
Objective: Much of the mild cognitive impairment (MCI) neuroimaging literature has exclusively focused on regions associated with Alzheimer's disease. Little research examined white matter abnormalities other brain regions, including those visual processing, despite evidence that appear in these early disease stages. Method: Diffusion tensor imaging (DTI) was utilized to examine participants (n = 44) completed baseline as part a longitudinal healthy aging study. Participants were divided...