Pedro Henrique Imenez Silva
A5030179327- Ion Transport and Channel Regulation
- Renal function and acid-base balance
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Helicobacter pylori-related gastroenterology studies
- Electrolyte and hormonal disorders
- Genetic Syndromes and Imprinting
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- Potassium and Related Disorders
- Fibroblast Growth Factor Research
- Nitric Oxide and Endothelin Effects
- Kidney Stones and Urolithiasis Treatments
- Digestive system and related health
- Receptor Mechanisms and Signaling
- Building materials and conservation
- Hormonal Regulation and Hypertension
- Pharmacological Effects and Toxicity Studies
- Psychology and Mental Health
- Magnesium in Health and Disease
- Cholesterol and Lipid Metabolism
- Muscle metabolism and nutrition
- Gastroesophageal reflux and treatments
- Angiogenesis and VEGF in Cancer
- Information Science and Libraries
University of Zurich
2017-2025
Erasmus MC
2023-2025
Hospital de São João
2009-2022
FORS – Swiss Centre of Expertise in the Social Sciences
2018-2019
Swiss National Science Foundation
2019
Universidade de São Paulo
2012-2017
During active inflammation, intraluminal intestinal pH is decreased in patients with inflammatory bowel disease [IBD]. Acidic may play a role IBD pathophysiology. Recently, proton-sensing G-protein coupled receptors were identified, including GPR4, OGR1 [GPR68], and TDAG8 [GPR65]. We investigated whether GPR4 involved inflammation.The of was assessed murine colitis models by chronic dextran sulphate sodium [DSS] administration cross-breeding into an IL-10 deficient background for development...
There seems to be a lack of consensus on the necessity and modality psychological specifically cognitive assessment candidates for kidney transplantation. Both points are often delegated individual hospitals/centres, whereas international guidelines inconsistent. We think it is essential investigate professionals' opinions advance towards consistent clinical practice. This paper presents results an survey among professionals, mainly nephrologists from CONNECT (Cognitive decline in...
Thiazide-induced hyponatremia is one of the most common forms hyponatremia, but its pathogenesis incompletely understood. Recent clinical data suggest links with prostaglandin E2 (PGE2) and a single nucleotide polymorphism (SNP) in transporter gene (SLCO2A1), it unknown if these findings also apply to general population.
pH-sensing ovarian cancer G-protein coupled receptor-1 [OGR1/GPR68] is regulated by key inflammatory cytokines. Patients suffering from bowel diseases [IBDs] express increased mucosal levels of OGR1 compared with non-IBD controls. may be relevant for progression fibrosis, as extracellular acidification leads to fibroblast activation and matrix remodelling. We aimed determine expression in fibrotic lesions the intestine Crohn's disease [CD] patients, effect Ogr1 deficiency fibrogenesis. Human...
Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD), and its prevalence increases progressive loss of function. MCI characterized by a decline performance greater than expected for an individual age education level but minimal instrumental activities daily living. Deterioration can affect one or several domains (attention, memory, executive functions, language, perceptual motor social cognition). Given the increasing disease, more CKD will also develop...
Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD], frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, anti-fibrotic therapies remain an unmet clinical need. Oxysterols oxidised cholesterol derivatives with important roles in various biological processes. The enzyme 25-hydroxylase [CH25H] converts to 25-hydroxycholesterol [25-HC], which modulates immune responses oxidative stress. In human intestinal samples...
Expression of the glutamine transporter SNAT3 increases in kidney during metabolic acidosis, suggesting a role ammoniagenesis. Microarray analysis Nrf2 knock-out (KO) mouse identified Snat3 as most significantly down-regulated transcript compared to wild-type (WT). We hypothesized that absence NRF2 would be unable induce under conditions acidosis and therefore reduce availability for Metabolic was induced 7 days WT KO mice. mice failed mRNA protein expression acidosis. However, there were no...