A5039460900- Clostridium difficile and Clostridium perfringens research
- Dialysis and Renal Disease Management
- Gut microbiota and health
- Nosocomial Infections in ICU
- Chronic Kidney Disease and Diabetes
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- DNA and Nucleic Acid Chemistry
- Renal Transplantation Outcomes and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Lysosomal Storage Disorders Research
- Blood Pressure and Hypertension Studies
- Microscopic Colitis
- Trypanosoma species research and implications
- DNA Repair Mechanisms
- Reproductive System and Pregnancy
- Health Sciences Research and Education
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Disease Prevention
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Toxoplasma gondii Research Studies
- Rheumatoid Arthritis Research and Therapies
- Brain Metastases and Treatment
- Advanced Glycation End Products research
University of Campania "Luigi Vanvitelli"
2023-2025
Target (United States)
2024
Seres Therapeutics (United States)
2022-2023
Global Neuroscience Initiative Foundation
2009
Stanford University
2006-2008
University of Minnesota
2007
University of Minnesota Medical Center
2006
Importance A safe and effective treatment for recurrent Clostridioides difficile infection (CDI) is urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted microbiome, which promotes spore germination recurrence. Objectives To evaluate safety rate of CDI recurrence after administration investigational microbiome therapeutic SER-109 through 24 weeks. Design, Setting, Participants This phase 3, single-arm, open-label trial (ECOSPOR IV) was conducted at 72 US...
Fabry Disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene on X chromosome, leading to deficiency α-galactosidase A (AGAL) enzyme activity. This leads accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), vital organs such as kidneys, heart, and nervous system. While FD was initially considered predominantly affecting males, recent studies have uncovered that heterozygous women, carrying single mutated gene, can manifest wide array...
ABSTRACT Cholinergic synapses are widespread throughout the human central nervous system. Their high density in thalamus, neocortex, limbic system and striatum suggests that cholinergic transmission plays a vital role memory, attention, learning other higher cognitive functions. As result, brain's occupies position research on normal cognition age-related decline, including dementias such as Alzheimer's disease. In addition to its brain, neuronal pathways essential for physiological...
Obestatin was identified as a brain/gut peptide hormone encoded by the ghrelin gene and found to interact with G protein-coupled receptor, GPR39. We investigated target cells for obestatin based on induction of an early-response c-fos in different tissues. After ip injection obestatin, staining nuclei gastric mucosa, intestinal villi, white adipose tissues, hepatic cords, kidney tubules. Immunohistochemical analyses using GPR39 antibodies further revealed cytoplasmic these In cultured 3T3-L1...
Although comorbidities are risk factors for recurrent Clostridioides difficile infection (rCDI), many clinical trials exclude patients with medical conditions such as malignancy or immunosuppression. In a phase 3, double-blind, placebo-controlled, randomized trial (ECOSPOR III), fecal microbiota spores, live (VOWST, Seres Therapeutics; hereafter "VOS," formerly SER-109), an oral therapeutic, significantly reduced the of rCDI at week 8. We evaluated efficacy VOS compared placebo in and other rCDI.
There seems to be a lack of consensus on the necessity and modality psychological specifically cognitive assessment candidates for kidney transplantation. Both points are often delegated individual hospitals/centres, whereas international guidelines inconsistent. We think it is essential investigate professionals' opinions advance towards consistent clinical practice. This paper presents results an survey among professionals, mainly nephrologists from CONNECT (Cognitive decline in...
The data in the present study show that DNA polymerase gamma and ligase III interact mitochondrial protein extracts from cultured HT1080 cells. An interaction was also observed between two recombinant proteins vitro. Expression of catalytically inert versions bind associated with reduced copy number integrity. In contrast, overexpression wild-type had no effect on or Experiments revealed facilitates a nicked substrate vitro, zinc finger domain is required for this activity. Mitochondrial...
Recent studies indicated that ovarian functions are regulated by diverse paracrine factors induced the preovulatory increases in circulating LH. Based on DNA microarray analyses and real-time RT-PCR, we found a major increase transcript levels of chemokine fractalkine after human chorionic gonadotropin (hCG) treatment during period gonadotropin-primed immature mice rats. Although CX3CR1, seven-transmembrane receptor for fractalkine, was also murine ovaries, its transcripts displayed minimal...
Abstract In addition to gonadotropins, many ovarian paracrine factors are crucial for optimal follicle rupture, oocyte maturation, and luteinization. Based on DNA microarray analyses, we found that transcripts the fibroblast growth factor-inducible-14 (Fn14) receptor increased after LH/human chorionic gonadotropin (hCG) treatment of gonadotropin-primed immature mice or rats. Fn14 is cognate TNF-related weak inducer apoptosis (TWEAK), a TNF superfamily member. TWEAK also were detected in...