A5036784252- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Mental Health and Psychiatry
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Obsessive-Compulsive Spectrum Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Eating Disorders and Behaviors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Mental Health Treatment and Access
- Dementia and Cognitive Impairment Research
- Treatment of Major Depression
- Epilepsy research and treatment
- Family Caregiving in Mental Illness
- Dialysis and Renal Disease Management
- Neuroscience and Neuropharmacology Research
University of Campania "Luigi Vanvitelli"
2015-2025
World Health Organization - Italy
2024
University of Naples Federico II
2009-2021
Mylan (Switzerland)
2021
University of Cagliari
2021
Hella (Germany)
2021
University of Chieti-Pescara
2021
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2004-2014
New York Medical College
1991
In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal the present study was identify predictors in with assess their relative contribution. Based on previous literature clinical experience, several were selected grouped three categories:...
<h3>Importance</h3> Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people schizophrenia. To date, this the first study using network analysis investigate associations among cognitive, psychopathologic, psychosocial variables in a large sample community-dwelling individuals <h3>Objective</h3> assess interplay psychopathologic variables, cognitive dysfunctions, capacity, personal resources,...
Abstract Background During the last decades, a renewed interest for negative symptoms (NS) was brought about by increased awareness that they interfere severely with real-life functioning, particularly when are primary and persistent. Methods In this guidance paper, we provide systematic review of evidence elaborate several recommendations conceptualization assessment NS in clinical trials practice. Results Expert consensus reviews have provided optimal persistent symptoms; second-generation...
The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low. Prospective identification variables associated with real-life functioning domains is essential for personalized integrated programs.To assess whether baseline illness-related variables, personal resources, context-related factors are work skills, interpersonal relationships, everyday life skills at 4-year follow-up.This multicenter...
Abstract Negative symptoms of schizophrenia remain a major therapeutic challenge. The progress in the conceptualization and assessment is not yet fully reflected by treatment research. Nevertheless, there growing evidence base regarding effects biological psychosocial interventions on negative symptoms. importance distinction between primary secondary for selection might seem evident, but currently available remains limited. Good clinical practice recommended Antipsychotic should be...
Abstract This electroencephalographic (EEG) study tested whether cortical EEG rhythms (especially delta and alpha) show a progressive increasing or decreasing trend across physiological aging. To this aim, we analyzed the type of correlation (linear nonlinear) between age. Resting eyes‐closed data were recorded in 108 young (Nyoung; age range: 18–50 years, mean 27.3 ± 7.3 SD) 107 elderly (Nold; 51–85 67.3 9.2 subjects. The interest (2–4 Hz), theta (4–8 alpha 1 (8–10.5 2 (10.5–13 beta (13–20...
Abstract Background The Brief Negative Symptom Scale (BNSS) was developed to address the main limitations of existing scales for assessment negative symptoms schizophrenia. initial validation scale by group involved in its development demonstrated good convergent and discriminant validity, a factor structure confirming two domains (reduced emotional/verbal expression anhedonia/asociality/avolition). However, only relatively small samples patients with schizophrenia were investigated. Further...
Improving real‐life functioning is the main goal of most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, interplay among illness‐related variables, personal resources, context‐related factors and a large sample patients same research has now completed 4‐year follow‐up original sample. In present study, we used analysis to test whether pattern relationships all variables...
Background The neurobiological underpinnings of avolition in schizophrenia remain unclear. Most brain imaging research has focused on reward prediction deficit and ventral striatum dysfunction, but findings are not consistent. In the light accumulating evidence that both dorsal caudate play a key role motivation, we investigated activation during processing or loss patients with schizophrenia. Method We used functional magnetic resonance to study Monetary Incentive Delay task schizophrenia,...
Negative symptoms are currently viewed as having a 2-dimensional structure, with factors reflecting diminished expression (EXP) and motivation pleasure (MAP). However, several factor-analytic studies suggest that the consensus around model is premature. The current study investigated cross-culturally validated factorial structure of BNSS-rated negative across range cultures languages.Participants included individuals diagnosed psychotic disorder who had been rated on Brief Symptom Scale...
Abstract Prior studies using exploratory factor analysis provide evidence that negative symptoms are best conceptualized as 2 dimensions reflecting diminished motivation and expression. However, the 2-dimensional model has yet to be evaluated more complex mathematical techniques capable of testing structure. In current study, network was applied evaluate latent structure a community-detection algorithm. Two were conducted included outpatients with schizophrenia (SZ; Study 1: n = 201; 2: 912)...