Fabio Di Fabio
A5021053072- Congenital heart defects research
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Mental Health and Psychiatry
- Mental Health Research Topics
- Coronary Artery Anomalies
- Genetics and Neurodevelopmental Disorders
- Advanced Neuroimaging Techniques and Applications
- Congenital Heart Disease Studies
- Psychosomatic Disorders and Their Treatments
- Resilience and Mental Health
- Personality Disorders and Psychopathology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Genomic variations and chromosomal abnormalities
- Face Recognition and Perception
- Cognitive Abilities and Testing
- Health, Environment, Cognitive Aging
- Diagnosis and treatment of tuberculosis
- Child and Adolescent Psychosocial and Emotional Development
- Electroconvulsive Therapy Studies
- Neuroscience and Neuropharmacology Research
Sapienza University of Rome
2015-2024
Policlinico Umberto I
2024
<h3>Importance</h3> Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people schizophrenia. To date, this the first study using network analysis investigate associations among cognitive, psychopathologic, psychosocial variables in a large sample community-dwelling individuals <h3>Objective</h3> assess interplay psychopathologic variables, cognitive dysfunctions, capacity, personal resources,...
Improving real‐life functioning is the main goal of most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, interplay among illness‐related variables, personal resources, context‐related factors and a large sample patients same research has now completed 4‐year follow‐up original sample. In present study, we used analysis to test whether pattern relationships all variables...
The study aimed to subtype patients with schizophrenia on the basis of social cognition (SC), and identify cut-offs that best discriminate among subtypes in 809 out-patients recruited context Italian Network for Research Psychoses.A two-step cluster analysis Awareness Social Inference Test (TASIT), Facial Emotion Identification Mayer-Salovey-Caruso Emotional Intelligence scores was performed. Classification regression tree used variables discriminated clusters.We identified three clusters,...
Objectives To evaluate whether biases may influence the findings of whole-brain structural imaging literature. Methods Forty-seven voxel-based meta-analyses including morphometry (VBM) studies in neuropsychiatric conditions were included, for a total 324 individual VBM studies. The sample size, overall number foci, and different moderators extracted both at level meta-analyses. Results Sample size ranged from 12 to 545 (median n = 47) per study. median reported foci study was six. with...
Abstract Background The increased use of the MATRICS Consensus Cognitive Battery (MCCB) to investigate cognitive dysfunctions in schizophrenia fostered interest its sensitivity context family studies. As various measures same domains may have different power distinguish between unaffected relatives patients and controls, relative MCCB tests for relative–control differences has be established. We compared scores 852 outpatients with (SCZ) those 342 (REL) a normative Italian sample 774 healthy...
Abstract Background Deficits in social cognition (SC) are significantly related to community functioning schizophrenia (SZ). Few studies investigated longitudinal changes SC and its impact on recovery. In the present study, we aimed: (a) estimate magnitude clinical significance of change outpatients with stable SZ who were assessed at baseline after 4 years, (b) identify predictors reliable clinically significant (RCSC), (c) determine whether over years predicted patient recovery follow-up....
Abstract Background 22q11.2 deletion syndrome (22q11.2DS) has been linked to an increased risk of early‐onset Parkinson's disease. However, the pathophysiological mechanisms underlying parkinsonism remain poorly understood. Objective The objective is investigate salivary total α‐synuclein levels in 22q11.2DS patients with and without parkinsonian motor signs. Methods This cross‐sectional study included 10 (Park+), ten (Park−), age sex‐comparable healthy subjects (HS). Salivary serum were...
Background 22q11.2 deletion syndrome (22q11.2DS) is considered as the genetic model of schizophrenia. However, its polymorphic nature has led researchers to further investigate neuropsychiatric manifestations. Methods We enrolled 56 adults (38 men, 18 women) diagnosed with 22q11.2DS. All subjects were evaluated by a multidisciplinary team. The features investigated means clinical and neurophysiological evaluation (video-EEG). Results Thirty per cent our patients left-handed. Fifty-eight had...
Schizotypy, or the set of personality traits related to schizophrenia, is considered an endophenotypic manifestation that more represented in first-degree relatives patients with schizophrenia than general population. The assessment schizotypy primarily based on self-reports, and for this reason it presents several limitations. In order assess schizotypy, study proposes a diagnostic instrument clinical reports.A sample 66 subjects, composed 25 outpatients 18 siblings these 23 healthy...
Abstract Background 22q11.2 Deletion Syndrome (22q11DS) represents one of the most important genetic risk factors for schizophrenia (SCZ) and a reliable biological model to study endophenotypic characters SCZ. The aim was investigate Social Cognition impairments in subjects with 22q11.2DS compared considerable sample schizophrenic patients. Methods Forty-four individuals (DEL) 18 patients psychosis (DEL_SCZ) were enrolled; these groups 887 780 healthy controls (HCs); latter recruited by...
Abstract Background Resilience is defined as the ability to modify thoughts cope with stressful events. Patients schizophrenia (SCZ) having higher resilience (HR) levels show less severe symptoms and better real-life functioning. However, clinical factors contributing determine in patients remain unclear. Thus, based on psychological, historical, environmental variables, we built a supervised machine learning algorithm classify HR or lower (LR). Methods SCZ from Italian Network for Research...
Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent reliable model for studying neurobiological underpinnings schizophrenia. The study social inference abilities in genetic condition at high psychosis, like 22q11.2DS, shed light on relationships between neurocognitive processes and patients' daily general functioning. sample consisted 1736 participants, divided into four groups: patients diagnosis...
Abstract Despite entailing more severe and uncommon side effects in 22q11.2DS compared to idiopathic schizophrenia, we strongly believe that clozapine should continue be considered the gold standard for all treatment‐resistant even 22qDS.