A5011793084- Congenital heart defects research
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Coronary Artery Anomalies
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Neuroscience and Music Perception
- Child Development and Digital Technology
- Congenital Heart Disease Studies
- Genomic variations and chromosomal abnormalities
- Diet and metabolism studies
- Virology and Viral Diseases
- Sleep and related disorders
- Digestive system and related health
- Acupuncture Treatment Research Studies
- ECG Monitoring and Analysis
- Cognitive Abilities and Testing
- Bioinformatics and Genomic Networks
University of Geneva
2017-2025
Center for Autisme
2024
University of Tübingen
2021
Office Médico Pédagogique
2017
Abstract The temporal variability of the thalamus in functional networks may provide valuable insights into pathophysiology schizophrenia. To address complexity role thalamic nuclei psychosis, we introduced micro‐co‐activation patterns (μCAPs) and employed this method on human genetic model schizophrenia 22q11.2 deletion syndrome (22q11.2DS). Participants underwent resting‐state MRI a data‐driven iterative process resulting identification six whole‐brain μCAPs with specific activity within...
Atypical deployment of social gaze is present early on in toddlers with autism spectrum disorders (ASDs). Yet, studies characterizing the developmental dynamic behind it are scarce. Here, we used a data-driven method to delineate change visual exploration interaction over childhood years autism. Longitudinal eye-tracking data were acquired as children ASD and their typically developing (TD) peers freely explored short cartoon movie. We found divergent moment-to-moment patterns compared TD...
How the brain's white-matter anatomy constrains brain activity is an open question that might give insights into mechanisms underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) a neurodevelopmental disorder with extremely high risk for psychosis providing test case to study developmental aspects of In this study, we used principles from network control theory probe implications aberrant structural connectivity functional dynamics in 22q11DS. We...
Converging evidence suggests that psychosis emerges from the complex interaction of genetic and environmental factors. Stressful life events (SLEs) play a prominent role in combination with coping strategies dysfunctional hypothalamus-pituitary-adrenal axis (HPAA). It has been proposed framework schizotypy might help disentangle between factors pathogenesis psychosis. Similarly, 22q11.2 deletion syndrome (22q11DS) is considered as model vulnerability. However, SLE remain largely unexplored...
Converging evidence suggests that sleep disturbances can directly contribute to a transdiagnostic combination of behavior and neurocognitive difficulties characterizing most forms psychopathology. However, it remains unclear how the growing comprehension neurophysiology should best inform quality assessment in mental health patients. To address this fundamental question, we performed deep multimodal behavioral phenotyping 37 individuals at high genetic risk for psychopathology due 22q11.2...
Background: Recent epidemiological evidence links early-life obesity and metabolic dysregulation to adult psychosis vulnerability, though a causal relationship remains unclear. Establishing causality in highly heritable psychotic disorders requires: 1) demonstrating that factors mediate between genetic vulnerability trajectory, 2) dissecting mechanisms leading genetically vulnerable individuals, 3) clarifying downstream neurodevelopmental pathways linking symptoms. Methods: To address these...
Converging evidence suggests that sleep disturbances can directly contribute to a transdiagnostic combination of behavior and neurocognitive difficulties characterizing most forms psychopathology. However, it remains unclear how the growing comprehension neurophysiology should best inform quality assessment in mental health patients. To address this fundamental question, we performed deep multimodal behavioral phenotyping 37 individuals at high genetic risk for psychopathology due 22q11.2...
<h2>Abstract</h2><h3>Background</h3> Hippocampal alterations are among the most replicated neuroimaging findings across psychosis spectrum. Moreover, there is strong translational evidence that preserving maturation of hippocampal networks in mice models prevents progression cognitive deficits. However, developmental trajectory functional connectivity (HFC) and its contribution to not well characterized human population. 22q11 deletion syndrome (22q11DS) offers a unique model for...
Abstract Prodromal positive psychotic symptoms and anxiety are two strong risk factors for schizophrenia in 22q11.2 deletion syndrome (22q11DS). The analysis of large-scale brain network dynamics during rest is promising to investigate aberrant function identify potentially more reliable biomarkers. We retrieved examined functional networks using innovation-driven co-activation patterns (iCAPs) probed into signatures prodromal anxiety. Patients with 22q11DS had shorter activation cognitive...
Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping white matter connections, as well synaptic density. However, relationship between whole-brain dynamics and underlying networks in neurodevelopment largely unknown. In this study, we focused how structural connectome shapes emerging cerebral ages 6 33 years, using diffusion magnetic resonance imaging combined into a spatiotemporal connectivity framework. We defined two new...
22q11.2 deletion syndrome (22q11DS) represents a homogeneous model of schizophrenia particularly suitable for the search neural biomarkers psychosis. Impairments in structural connectivity related to presence psychotic symptoms have been reported patients with 22q11DS. However, relationships between changes different symptomatic profiles are still largely unknown and warrant further investigations. In this study, we used discriminate 22q11DS (N = 31) without attenuated positive symptoms....
Background Schizophrenia is currently considered a neurodevelopmental disorder of connectivity. Still few studies have investigated how brain networks develop in children and adolescents who are at risk for developing psychosis. 22q11.2 Deletion Syndrome (22q11DS) offers unique opportunity to investigate the pathogenesis schizophrenia from perspective. Structural covariance (SC) powerful approach explore morphometric relations between regions that can furthermore detect biomarkers psychosis,...
Abstract Background Patients with 22q11.2 deletion syndrome (22q11DS) present a high risk of developing psychosis. While clinical and cognitive predictors for the conversion towards full-blown psychotic disorder are well defined largely used in practice, neural biomarkers do not yet exist. However, number investigations indicated an association between abnormalities cortical morphology higher symptoms severities patients 22q11DS. Nevertheless, few studies included homogeneous groups...
22q11.2 deletion syndrome (22q11DS) contributes dramatically to increased genetic risk for psychopathology, and in particular schizophrenia. Sleep disorders, including obstructive sleep apnea (OSA), are also highly prevalent, making 22q11DS a unique model explore their impact on psychosis vulnerability. Still, the contribution of disturbances vulnerability remains unclear. We characterized phenotype 69 individuals with 38 healthy controls actigraphy questionnaires. Psychiatric symptoms were...
22q11.2 Deletion Syndrome (22q11DS) is recognized as one of the strongest genetic risk factors for development psychopathology, including dramatically increased prevalence schizophrenia anxiety disorders, mood disorders and ADHD. Despite sharing a homogenous deletion, psychiatric phenotype in 22q11DS still present significant variability across subjects. The origins such remain largely unclear. Levels parental psychopathology could significantly contribute to phenotypic offspring through...
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a genetic disease associated with an increased risk for schizophrenia and specific cognitive profile. In this paper, we challenge the current view of spared verbal memory in 22q11.2DS by investigating consolidation processes over extended time span to further qualify neuropsychological Our hypotheses are based on brain anomalies medial temporal lobes consistently reported syndrome.Eighty-four participants (45 22q11.2DS), aged 8–24 years...
Abstract How the brain’s white-matter anatomy constrains brain activity is an open question that might give insights into mechanisms underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) a neurodevelopmental disorder with extremely high risk for psychosis providing test case to study developmental aspects of In this study, we used principles from network control theory probe implications aberrant structural connectivity functional dynamics in...
Causal interactions between specific psychiatric symptoms could contribute to the heterogenous clinical trajectories observed in early psychopathology. Current diagnostic approaches merge manifestations that co-occur across subjects and significantly hinder our understanding of pathways connecting individual symptoms. Network analysis techniques have emerged as alternative help shed light on complex dynamics The present study attempts address two main limitations opinion hindered application...